Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ

The recognition by the T cell receptor (TCR) of self-peptides presented by the major histocompatibility complex (MHC) on antigen-presenting cells, such as dendritic cells and thymic epithelial cells, controls T cell fate in the thymus, with weak TCR signals inducing survival (positive selection) and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science signaling 2013-10, Vol.6 (297), p.ra92-ra92
Hauptverfasser:	Melichar, Heather J, Ross, Jenny O, Herzmark, Paul, Hogquist, Kristin A, Robey, Ellen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - immunology Calcium - immunology Calcium - metabolism Cell Movement - immunology Cells, Cultured Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Histocompatibility Antigens Class I - immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Fluorescence, Multiphoton Organ Culture Techniques Ovalbumin - immunology Peptide Fragments - immunology Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymocytes - immunology Thymocytes - metabolism Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!