Knockdown of CDC2 expression inhibits proliferation, enhances apoptosis, and increases chemosensitivity to temozolomide in glioblastoma cells

Cell division cycle 2 (CDC2) is always overexpressed in malignant tumor cells and is correlated with chemosensitivity, but it is unclear whether CDC2 overexpression contributes to the chemoresistance potential of glioma cells. The aim of study was to determine the relationship of CDC2 expression wit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2015, Vol.32 (1), p.378-378, Article 378
Hauptverfasser:	Zhou, Baosheng, Bu, Guoyun, Zhou, Yipin, Zhao, Yue, Li, Wei, Li, Mu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Blotting, Western Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology CDC2 Protein Kinase Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - physiology Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Drug Resistance, Neoplasm - genetics Female Gene Knockdown Techniques Glioblastoma - genetics Glioblastoma - mortality Glioblastoma - pathology Hematology Humans Immunohistochemistry Internal Medicine Kaplan-Meier Estimate Lentivirus Male Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pathology Proportional Hazards Models Reverse Transcriptase Polymerase Chain Reaction Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!