Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children
Hepatitis B virus (HBV) infection is usually vertically transmitted from the mother to child during birth in Asian countries. Despite immunization, immunoprophylaxis failure is well‐documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chr...
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| Veröffentlicht in: | Journal of medical virology 2015-08, Vol.87 (8), p.1344-1350 |
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| creator | Lee, Le Ye Aw, Marion Rauff, Mary Loh, Kah-Sin Lim, Seng Gee Lee, Guan Huei |
| description | Hepatitis B virus (HBV) infection is usually vertically transmitted from the mother to child during birth in Asian countries. Despite immunization, immunoprophylaxis failure is well‐documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic HBV‐infected mothers and to determine risk factors for failure. This was an observational study involving chronic hepatitis B infected mothers seen at a tertiary care center in Singapore between June 2009 and December 2013. Infants born to these mothers were recruited after they had completed the recommended vaccination schedule. Serological testing for the children was performed 3 months after completion of the last dose of vaccine. HBV surface gene sequencing was carried out if HBV DNA was detectable in the children. Among the 161 mothers enrolled, most were HBeAg negative. HBeAg positive mothers were younger and had a significantly higher viral load (6.5 log) as compared to HBeAg negative mothers (1.35 log) (P |
| doi_str_mv | 10.1002/jmv.24193 |
| format | Article |
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Despite immunization, immunoprophylaxis failure is well‐documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic HBV‐infected mothers and to determine risk factors for failure. This was an observational study involving chronic hepatitis B infected mothers seen at a tertiary care center in Singapore between June 2009 and December 2013. Infants born to these mothers were recruited after they had completed the recommended vaccination schedule. Serological testing for the children was performed 3 months after completion of the last dose of vaccine. HBV surface gene sequencing was carried out if HBV DNA was detectable in the children. Among the 161 mothers enrolled, most were HBeAg negative. HBeAg positive mothers were younger and had a significantly higher viral load (6.5 log) as compared to HBeAg negative mothers (1.35 log) (P < 0.001). Four children (2.6%) were found to have immunoprophylaxis failure. Two occurred in children delivered by mothers with extremely high viral load of more than 5 × 107 IU/ml. HBV surface gene mutations were detected in most children (3 out of 4) with immunoprophylaxis failure. The overall effectiveness of the hepatitis B vaccination program was high. High maternal viral load and presence of surface gene mutants may be potential contributors. J. Med. Virol. 87:1344–1350, 2015. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24193</identifier><identifier>PMID: 25782362</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Cohort Studies ; DNA, Viral - chemistry ; DNA, Viral - genetics ; Female ; Genetics ; Hepatitis ; Hepatitis B - prevention & control ; Hepatitis B - virology ; hepatitis B chronic carrier mothers ; Hepatitis B Surface Antigens - genetics ; hepatitis B surface gene mutations ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - immunology ; Hepatitis B virus - isolation & purification ; Humans ; Immunization ; Immunization - methods ; immunoprophylaxis failure in children ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical - prevention & control ; Male ; maternal HBV DNA (viral load) ; Mutant Proteins - genetics ; Mutation ; Pediatrics ; Pregnancy ; Sequence Analysis, DNA ; Singapore ; Treatment Failure ; vertical transmission ; Virology ; Young Adult</subject><ispartof>Journal of medical virology, 2015-08, Vol.87 (8), p.1344-1350</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4903-e9e7b28283c309cf9f5b630d29728d2ed93b3822d4ba7516bf20e35433517c273</citedby><cites>FETCH-LOGICAL-c4903-e9e7b28283c309cf9f5b630d29728d2ed93b3822d4ba7516bf20e35433517c273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24193$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24193$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25782362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Le Ye</creatorcontrib><creatorcontrib>Aw, Marion</creatorcontrib><creatorcontrib>Rauff, Mary</creatorcontrib><creatorcontrib>Loh, Kah-Sin</creatorcontrib><creatorcontrib>Lim, Seng Gee</creatorcontrib><creatorcontrib>Lee, Guan Huei</creatorcontrib><title>Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Hepatitis B virus (HBV) infection is usually vertically transmitted from the mother to child during birth in Asian countries. Despite immunization, immunoprophylaxis failure is well‐documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic HBV‐infected mothers and to determine risk factors for failure. This was an observational study involving chronic hepatitis B infected mothers seen at a tertiary care center in Singapore between June 2009 and December 2013. Infants born to these mothers were recruited after they had completed the recommended vaccination schedule. Serological testing for the children was performed 3 months after completion of the last dose of vaccine. HBV surface gene sequencing was carried out if HBV DNA was detectable in the children. Among the 161 mothers enrolled, most were HBeAg negative. HBeAg positive mothers were younger and had a significantly higher viral load (6.5 log) as compared to HBeAg negative mothers (1.35 log) (P < 0.001). Four children (2.6%) were found to have immunoprophylaxis failure. Two occurred in children delivered by mothers with extremely high viral load of more than 5 × 107 IU/ml. HBV surface gene mutations were detected in most children (3 out of 4) with immunoprophylaxis failure. The overall effectiveness of the hepatitis B vaccination program was high. High maternal viral load and presence of surface gene mutants may be potential contributors. J. Med. Virol. 87:1344–1350, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Cohort Studies</subject><subject>DNA, Viral - chemistry</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Genetics</subject><subject>Hepatitis</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - virology</subject><subject>hepatitis B chronic carrier mothers</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>hepatitis B surface gene mutations</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization - methods</subject><subject>immunoprophylaxis failure in children</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Male</subject><subject>maternal HBV DNA (viral load)</subject><subject>Mutant Proteins - genetics</subject><subject>Mutation</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Sequence Analysis, DNA</subject><subject>Singapore</subject><subject>Treatment Failure</subject><subject>vertical transmission</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAURS0EokNhwR9AltjAIq0_Yide0op2gGnZlLK0HOeZ8ZA4qZ2Uzr_H7bQVQkJi9aSnc490dRF6TckBJYQdbvrrA1ZSxZ-gBSVKFopU9ClaEFrKQkoq9tCLlDaEkFox9hztMVHVjEu2QGkJo5n85BM-wr7v5zCMcRjX287c5J8zvpsjYBNaPK0BjxESBAt4cHj9RzLN0Zn8_gEBcD9PJkwJ-3CXMc6BnaDFdu27NkJ4iZ450yV4dX_30beTjxfHy2L19fTT8YdVYUtFeAEKqobVrOaWE2WdcqKRnLRMVaxuGbSKN7xmrC0bUwkqG8cIcFFyLmhlWcX30budNze6miFNuvfJQteZAMOcNJWqzC4u_wetJZGSCJ7Rt3-hm2GOIRe5pQRhkjOVqfc7ysYhpQhOj9H3Jm41Jfp2NJ1H03ejZfbNvXFuemgfyYeVMnC4A375Drb_NunPZ5cPymKX8GmCm8eEiT91blsJ_f38VB8tL1aX_PyLPuO_AZamrzs</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Lee, Le Ye</creator><creator>Aw, Marion</creator><creator>Rauff, Mary</creator><creator>Loh, Kah-Sin</creator><creator>Lim, Seng Gee</creator><creator>Lee, Guan Huei</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children</title><author>Lee, Le Ye ; Aw, Marion ; Rauff, Mary ; Loh, Kah-Sin ; Lim, Seng Gee ; Lee, Guan Huei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4903-e9e7b28283c309cf9f5b630d29728d2ed93b3822d4ba7516bf20e35433517c273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Cohort Studies</topic><topic>DNA, Viral - chemistry</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Genetics</topic><topic>Hepatitis</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B - virology</topic><topic>hepatitis B chronic carrier mothers</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>hepatitis B surface gene mutations</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization - methods</topic><topic>immunoprophylaxis failure in children</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Male</topic><topic>maternal HBV DNA (viral load)</topic><topic>Mutant Proteins - genetics</topic><topic>Mutation</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Sequence Analysis, DNA</topic><topic>Singapore</topic><topic>Treatment Failure</topic><topic>vertical transmission</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Le Ye</creatorcontrib><creatorcontrib>Aw, Marion</creatorcontrib><creatorcontrib>Rauff, Mary</creatorcontrib><creatorcontrib>Loh, Kah-Sin</creatorcontrib><creatorcontrib>Lim, Seng Gee</creatorcontrib><creatorcontrib>Lee, Guan Huei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Le Ye</au><au>Aw, Marion</au><au>Rauff, Mary</au><au>Loh, Kah-Sin</au><au>Lim, Seng Gee</au><au>Lee, Guan Huei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2015-08</date><risdate>2015</risdate><volume>87</volume><issue>8</issue><spage>1344</spage><epage>1350</epage><pages>1344-1350</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Hepatitis B virus (HBV) infection is usually vertically transmitted from the mother to child during birth in Asian countries. Despite immunization, immunoprophylaxis failure is well‐documented. The aim of the study was to study immunoprophylaxis failure rate in the cohort of infants delivered by chronic HBV‐infected mothers and to determine risk factors for failure. This was an observational study involving chronic hepatitis B infected mothers seen at a tertiary care center in Singapore between June 2009 and December 2013. Infants born to these mothers were recruited after they had completed the recommended vaccination schedule. Serological testing for the children was performed 3 months after completion of the last dose of vaccine. HBV surface gene sequencing was carried out if HBV DNA was detectable in the children. Among the 161 mothers enrolled, most were HBeAg negative. HBeAg positive mothers were younger and had a significantly higher viral load (6.5 log) as compared to HBeAg negative mothers (1.35 log) (P < 0.001). Four children (2.6%) were found to have immunoprophylaxis failure. Two occurred in children delivered by mothers with extremely high viral load of more than 5 × 107 IU/ml. HBV surface gene mutations were detected in most children (3 out of 4) with immunoprophylaxis failure. The overall effectiveness of the hepatitis B vaccination program was high. High maternal viral load and presence of surface gene mutants may be potential contributors. J. Med. Virol. 87:1344–1350, 2015. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25782362</pmid><doi>10.1002/jmv.24193</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Cohort Studies DNA, Viral - chemistry DNA, Viral - genetics Female Genetics Hepatitis Hepatitis B - prevention & control Hepatitis B - virology hepatitis B chronic carrier mothers Hepatitis B Surface Antigens - genetics hepatitis B surface gene mutations Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Humans Immunization Immunization - methods immunoprophylaxis failure in children Infant Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Male maternal HBV DNA (viral load) Mutant Proteins - genetics Mutation Pediatrics Pregnancy Sequence Analysis, DNA Singapore Treatment Failure vertical transmission Virology Young Adult |
| title | Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children |
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