Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone

Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory agencies and pharmaceutical companies. Here, using amiodarone (AMIO) as an example, we demonstrate the use of physiologically based pharmacoki...

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Veröffentlicht in:	Drug metabolism and disposition 2015-02, Vol.43 (2), p.182-189
Hauptverfasser:	Chen, Yuan, Mao, Jialin, Hop, Cornelis E.C.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Amiodarone - administration & dosage Amiodarone - analogs & derivatives Amiodarone - antagonists & inhibitors Amiodarone - blood Amiodarone - metabolism Amiodarone - pharmacokinetics Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - metabolism Anti-Arrhythmia Agents - pharmacokinetics Biotransformation - drug effects Computer Simulation Cytochrome P-450 CYP2C9 Inhibitors - blood Cytochrome P-450 CYP2C9 Inhibitors - chemistry Cytochrome P-450 CYP2C9 Inhibitors - metabolism Cytochrome P-450 CYP2C9 Inhibitors - pharmacokinetics Cytochrome P-450 CYP2D6 Inhibitors - blood Cytochrome P-450 CYP2D6 Inhibitors - chemistry Cytochrome P-450 CYP2D6 Inhibitors - metabolism Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics Cytochrome P-450 CYP3A Inhibitors - blood Cytochrome P-450 CYP3A Inhibitors - chemistry Cytochrome P-450 CYP3A Inhibitors - metabolism Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics Dose-Response Relationship, Drug Drug Interactions Expert Systems Female Humans Infusions, Intravenous Liver - drug effects Liver - enzymology Liver - metabolism Male Middle Aged Models, Biological Reproducibility of Results Young Adult
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