Spinal Implants: Bioengineering a Multicomponent Spinal Motion Segment Construct-A 3D Model for Complex Tissue Engineering (Adv. Healthcare Mater. 1/2015)

Spinal Implants: Bioengineering a Multicomponent Spinal Motion Segment Construct-A 3D Model for Complex Tissue Engineering (Adv. Healthcare Mater. 1/2015)

The first realization of a bioengineered quadri‐phasic spinal motion segment (SMS) is reported by B. P. Chan and co‐workers on page 99 using mesenchymal stem cells (MSC) and collagen as starting materials. The construct consists of two vertebrae‐endplate‐like subunits, sandwiching a multi‐lamellae a...

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Veröffentlicht in:Advanced healthcare materials 2015-01, Vol.4 (1), p.98-98
Hauptverfasser: Chik, Tsz Kit, Chooi, Wai Hon, Li, Yuk Yin, Ho, Fu Chak, Cheng, Hiu Wa, Choy, Tsz Hang, Sze, Kam Yim, Luk, Keith Kei Dip, Cheung, Kenneth Man Chi, Chan, Barbara Pui
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Bioengineering
collagen
complex tissue engineering
mesenchymal stem cell
microencapsulation
spinal motion segment
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container_end_page 98
container_issue 1
container_start_page 98
container_title Advanced healthcare materials
container_volume 4
creator Chik, Tsz Kit
Chooi, Wai Hon
Li, Yuk Yin
Ho, Fu Chak
Cheng, Hiu Wa
Choy, Tsz Hang
Sze, Kam Yim
Luk, Keith Kei Dip
Cheung, Kenneth Man Chi
Chan, Barbara Pui
description The first realization of a bioengineered quadri‐phasic spinal motion segment (SMS) is reported by B. P. Chan and co‐workers on page 99 using mesenchymal stem cells (MSC) and collagen as starting materials. The construct consists of two vertebrae‐endplate‐like subunits, sandwiching a multi‐lamellae annulus fibrosus‐like component, which entraps a soft nucleus pulposus‐like core. The complex hierarchical organization ranges from nano‐fibrous collagen meshwork to micrometer‐sized MSC‐collagen beads, and from millimeter‐sized individual tissue components to centimeter‐sized SMS construct.
doi_str_mv 10.1002/adhm.201570004
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source Wiley Online Library Journals Frontfile Complete
subjects Bioengineering
collagen
complex tissue engineering
mesenchymal stem cell
microencapsulation
spinal motion segment
title Spinal Implants: Bioengineering a Multicomponent Spinal Motion Segment Construct-A 3D Model for Complex Tissue Engineering (Adv. Healthcare Mater. 1/2015)
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