The Interplay between Autophagy and Apoptosis Induced by One Synthetic Curcumin Derivative Hydrazinobenzoylcurcumin in A549 Lung Cancer Cells

ABSTRACT The two important cell autonomic responses, autophagy, and apoptosis, play critical roles in cellular homeostasis and survival. By studying of the synthetic curcumin derivative hydrazinobenzoylcurcumin (HBC), we revealed that it could induce autophagy in nonsmall lung cancer cells (A549). H...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2015-06, Vol.29 (6), p.267-273
Hauptverfasser:	Zhou, Guang-Zhou, Sun, Gang-Chun, Zhang, Shuai-Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Blotting, Western Cell Culture Techniques Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Curcumin - analogs & derivatives Curcumin - pharmacology Curcumin Derivative Dose-Response Relationship, Drug Fluorescent Antibody Technique Humans Interplay Lung cancer Poly(ADP-ribose) Polymerases - genetics Pyrazoles - pharmacology
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