Role of CD154 in cancer pathogenesis and immunotherapy
Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in many types of tumors. • The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells. • CD154 ac...
Gespeichert in:
| Veröffentlicht in: | Cancer treatment reviews 2015-05, Vol.41 (5), p.431-440 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 440 |
|---|---|
| container_issue | 5 |
| container_start_page | 431 |
| container_title | Cancer treatment reviews |
| container_volume | 41 |
| creator | Hassan, Ghada S Stagg, John Mourad, Walid |
| description | Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in many types of tumors. • The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells. • CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells. • The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients. |
| doi_str_mv | 10.1016/j.ctrv.2015.03.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694969089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0305737215000523</els_id><sourcerecordid>1694969089</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-bd5834d1c548376b021804cd2d46fa525f90787e3ebdc9e44d900a8f4195c2083</originalsourceid><addsrcrecordid>eNp9kc9rFDEYhoNY7Lb6D3iQOXqZ8cuvmQREkK3WQqFQ9RyyyTc268xkTWYK-9-bYasHD57CB8_7Qp6XkNcUGgq0fbdv3JweGwZUNsAbgO4Z2VDJWU112z0nG-Ag64537Jxc5LwHAM1b_YKcM6kEZ0xtSHsfB6xiX22vqBRVmCpnJ4epOtj5If7ACXPIlZ18FcZxmeL8gMkeji_JWW-HjK-e3kvy_fOnb9sv9e3d9c32423tpOjmeuel4sLTcinetTtgVIFwnnnR9lYy2WvoVIccd95pFMJrAKt6QbV0DBS_JG9PvYcUfy2YZzOG7HAY7IRxyYa2WuhWg9IFZSfUpZhzwt4cUhhtOhoKZvVl9mb1ZVZfBrgpvkrozVP_shvR_438EVSA9ycAyy8fAyaTXcBiyIeEbjY-hv_3f_gn7oYwBWeHn3jEvI9Lmoo_Q01mBszXdbF1MCrLWJJx_huH546A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1694969089</pqid></control><display><type>article</type><title>Role of CD154 in cancer pathogenesis and immunotherapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Hassan, Ghada S ; Stagg, John ; Mourad, Walid</creator><creatorcontrib>Hassan, Ghada S ; Stagg, John ; Mourad, Walid</creatorcontrib><description>Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in many types of tumors. • The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells. • CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells. • The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients.</description><identifier>ISSN: 0305-7372</identifier><identifier>EISSN: 1532-1967</identifier><identifier>DOI: 10.1016/j.ctrv.2015.03.007</identifier><identifier>PMID: 25843228</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animal model ; Animals ; Apoptosis ; Cancer ; CD154 ; CD40 ; CD40 Ligand - immunology ; Clinical trial ; Hematology, Oncology and Palliative Medicine ; Humans ; Immune response ; Immunotherapy - methods ; Neoplasms - immunology ; Neoplasms - therapy ; Proliferation</subject><ispartof>Cancer treatment reviews, 2015-05, Vol.41 (5), p.431-440</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-bd5834d1c548376b021804cd2d46fa525f90787e3ebdc9e44d900a8f4195c2083</citedby><cites>FETCH-LOGICAL-c547t-bd5834d1c548376b021804cd2d46fa525f90787e3ebdc9e44d900a8f4195c2083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0305737215000523$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25843228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassan, Ghada S</creatorcontrib><creatorcontrib>Stagg, John</creatorcontrib><creatorcontrib>Mourad, Walid</creatorcontrib><title>Role of CD154 in cancer pathogenesis and immunotherapy</title><title>Cancer treatment reviews</title><addtitle>Cancer Treat Rev</addtitle><description>Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in many types of tumors. • The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells. • CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells. • The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients.</description><subject>Animal model</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>CD154</subject><subject>CD40</subject><subject>CD40 Ligand - immunology</subject><subject>Clinical trial</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunotherapy - methods</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Proliferation</subject><issn>0305-7372</issn><issn>1532-1967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFDEYhoNY7Lb6D3iQOXqZ8cuvmQREkK3WQqFQ9RyyyTc268xkTWYK-9-bYasHD57CB8_7Qp6XkNcUGgq0fbdv3JweGwZUNsAbgO4Z2VDJWU112z0nG-Ag64537Jxc5LwHAM1b_YKcM6kEZ0xtSHsfB6xiX22vqBRVmCpnJ4epOtj5If7ACXPIlZ18FcZxmeL8gMkeji_JWW-HjK-e3kvy_fOnb9sv9e3d9c32423tpOjmeuel4sLTcinetTtgVIFwnnnR9lYy2WvoVIccd95pFMJrAKt6QbV0DBS_JG9PvYcUfy2YZzOG7HAY7IRxyYa2WuhWg9IFZSfUpZhzwt4cUhhtOhoKZvVl9mb1ZVZfBrgpvkrozVP_shvR_438EVSA9ycAyy8fAyaTXcBiyIeEbjY-hv_3f_gn7oYwBWeHn3jEvI9Lmoo_Q01mBszXdbF1MCrLWJJx_huH546A</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Hassan, Ghada S</creator><creator>Stagg, John</creator><creator>Mourad, Walid</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Role of CD154 in cancer pathogenesis and immunotherapy</title><author>Hassan, Ghada S ; Stagg, John ; Mourad, Walid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-bd5834d1c548376b021804cd2d46fa525f90787e3ebdc9e44d900a8f4195c2083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal model</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>CD154</topic><topic>CD40</topic><topic>CD40 Ligand - immunology</topic><topic>Clinical trial</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunotherapy - methods</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Proliferation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassan, Ghada S</creatorcontrib><creatorcontrib>Stagg, John</creatorcontrib><creatorcontrib>Mourad, Walid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer treatment reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassan, Ghada S</au><au>Stagg, John</au><au>Mourad, Walid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of CD154 in cancer pathogenesis and immunotherapy</atitle><jtitle>Cancer treatment reviews</jtitle><addtitle>Cancer Treat Rev</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>41</volume><issue>5</issue><spage>431</spage><epage>440</epage><pages>431-440</pages><issn>0305-7372</issn><eissn>1532-1967</eissn><abstract>Highlights • CD154 is a co-stimulatory molecule known for its role in inflammatory and autoimmune diseases. • CD154 and its receptor, CD40 are expressed in many types of tumors. • The CD154/CD40 interaction is capable of inducing the proliferation and rescue from apoptosis of tumor cells. • CD154 activates anti-tumoral immunity, and by engaging CD40 may induce apoptosis of tumor cells. • The role of CD154 in cancer immunotherapy was demonstrated in animal models and clinically assessed in patients.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25843228</pmid><doi>10.1016/j.ctrv.2015.03.007</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7372 |
| ispartof | Cancer treatment reviews, 2015-05, Vol.41 (5), p.431-440 |
| issn | 0305-7372 1532-1967 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1694969089 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal model Animals Apoptosis Cancer CD154 CD40 CD40 Ligand - immunology Clinical trial Hematology, Oncology and Palliative Medicine Humans Immune response Immunotherapy - methods Neoplasms - immunology Neoplasms - therapy Proliferation |
| title | Role of CD154 in cancer pathogenesis and immunotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T22%3A16%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20CD154%20in%20cancer%20pathogenesis%20and%20immunotherapy&rft.jtitle=Cancer%20treatment%20reviews&rft.au=Hassan,%20Ghada%20S&rft.date=2015-05-01&rft.volume=41&rft.issue=5&rft.spage=431&rft.epage=440&rft.pages=431-440&rft.issn=0305-7372&rft.eissn=1532-1967&rft_id=info:doi/10.1016/j.ctrv.2015.03.007&rft_dat=%3Cproquest_cross%3E1694969089%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1694969089&rft_id=info:pmid/25843228&rft_els_id=S0305737215000523&rfr_iscdi=true |