Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors

conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between...

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Veröffentlicht in:	Age and ageing 2014-09, Vol.43 (5), p.681-686
Hauptverfasser:	Sun, Dong, Zhang, Junjian, Fan, Yuanteng, Liu, Xuan, Gao, Yongzhe, Wu, Guangyao, Yan, Yatao, Zeng, Junjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Biomarkers - metabolism Brain Cardiovascular disease Care and treatment Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - etiology Cognition Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - psychology Correlation analysis Cross-Sectional Studies Executive Function Female Glutamic Acid - metabolism Glutamine Glutamine - metabolism Hippocampus - metabolism Humans Male Memory, Short-Term Mental Recall Metabolites Middle Aged Neuropsychological Tests Nuclear magnetic resonance spectroscopy Patients Predictive Value of Tests Prefrontal Cortex - metabolism Proton Magnetic Resonance Spectroscopy Risk Factors Stroke Stroke (Disease)
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