Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors
conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between...
Gespeichert in:
| Veröffentlicht in: | Age and ageing 2014-09, Vol.43 (5), p.681-686 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 686 |
|---|---|
| container_issue | 5 |
| container_start_page | 681 |
| container_title | Age and ageing |
| container_volume | 43 |
| creator | Sun, Dong Zhang, Junjian Fan, Yuanteng Liu, Xuan Gao, Yongzhe Wu, Guangyao Yan, Yatao Zeng, Junjie |
| description | conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment.
a group of 54 stroke-free subjects with various VRFs underwent comprehensive cognitive assessments and (1)H MRS scan of the left hippocampus and prefrontal cortex. We indirectly measured the concentrations of N-acetylaspartate (NAA), choline, inositol, creatine (Cr) and total concentrations of glutamate plus glutamine (Glx). VRFs were quantified by Framingham stroke risk profile (FSRP) score. Subjects were divided into low- (20%) groups according to their FSRP scores. Pearson and partial correlation analysis were used to investigate the correlation between FSRP scores and cognitive performance along with the brain metabolism.
compared with subjects in low-risk group, high-risk group subjects had significantly poor performances on the tasks of working memory, delayed recall and executive function. In high-risk group, hippocampal Glx/Cr ratios and prefrontal NAA/Cr ratios were significantly lower than those in low-risk group. Lower prefrontal NAA/Cr ratios were associated with executive dysfunction, and lower hippocampal Glx/Cr ratios were associated with impaired delayed recall.
abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by (1)H MRS may serve as important markers for monitoring VRFs burden. |
| doi_str_mv | 10.1093/ageing/afu027 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694967887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A392801426</galeid><sourcerecordid>A392801426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-6404910c9d5684314b87c88177da2867e64b9f8ee9ebce2a0376a4843047270e3</originalsourceid><addsrcrecordid>eNqF0U2LFDEQBuAgijuuHr1KwIuXdpN0Oh_HYfALFvai55DOVLfZTSdjkh7dk3_dDLMqePFUVPFQVPEi9JKSt5To_srO4ON8ZaeVMPkIbSgXqmOq54_RhhDCOiKZvkDPSrltLR0oe4ouGBfNcbZBP7djTHmxAQc4Qig4TXjM1ke8QLVjCr5CwYu9b_3e2wrYpTn66o-A_XKwPi8QK26-1JzuoJsyAD7Y6tu44O--fsUOMow5HW1xa7AZZ1_u8GRdTbk8R08mGwq8eKiX6Mv7d593H7vrmw-fdtvrzvGe1k5wwjUlTu8HodqEj0o6paiUe8uUkCD4qCcFoGF0wCzppbC8ScIlkwT6S_TmvPeQ07cVSjWLLw5CsBHSWgwVmmshlZL_p8MgiaJ8oI2-_ofepjXH9shJaSK5YifVndVsAxgfXYoVflSXQoAZTPtzd2O2vWaKUM7EX-9yKiXDZA7ZLzbfG0rMKXRzDt2cQ2_-1cMV69hS-qN_p9z_Ai-FqXc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1559074821</pqid></control><display><type>article</type><title>Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Oxford Journals - Connect here FIRST to enable access</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Sun, Dong ; Zhang, Junjian ; Fan, Yuanteng ; Liu, Xuan ; Gao, Yongzhe ; Wu, Guangyao ; Yan, Yatao ; Zeng, Junjie</creator><creatorcontrib>Sun, Dong ; Zhang, Junjian ; Fan, Yuanteng ; Liu, Xuan ; Gao, Yongzhe ; Wu, Guangyao ; Yan, Yatao ; Zeng, Junjie</creatorcontrib><description>conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment.
a group of 54 stroke-free subjects with various VRFs underwent comprehensive cognitive assessments and (1)H MRS scan of the left hippocampus and prefrontal cortex. We indirectly measured the concentrations of N-acetylaspartate (NAA), choline, inositol, creatine (Cr) and total concentrations of glutamate plus glutamine (Glx). VRFs were quantified by Framingham stroke risk profile (FSRP) score. Subjects were divided into low- (<10%), medium- (10-20%) and high-risk (>20%) groups according to their FSRP scores. Pearson and partial correlation analysis were used to investigate the correlation between FSRP scores and cognitive performance along with the brain metabolism.
compared with subjects in low-risk group, high-risk group subjects had significantly poor performances on the tasks of working memory, delayed recall and executive function. In high-risk group, hippocampal Glx/Cr ratios and prefrontal NAA/Cr ratios were significantly lower than those in low-risk group. Lower prefrontal NAA/Cr ratios were associated with executive dysfunction, and lower hippocampal Glx/Cr ratios were associated with impaired delayed recall.
abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by (1)H MRS may serve as important markers for monitoring VRFs burden.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afu027</identifier><identifier>PMID: 24614642</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Analysis ; Biomarkers - metabolism ; Brain ; Cardiovascular disease ; Care and treatment ; Cerebrovascular Disorders - diagnosis ; Cerebrovascular Disorders - etiology ; Cognition ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognition Disorders - metabolism ; Cognition Disorders - psychology ; Correlation analysis ; Cross-Sectional Studies ; Executive Function ; Female ; Glutamic Acid - metabolism ; Glutamine ; Glutamine - metabolism ; Hippocampus - metabolism ; Humans ; Male ; Memory, Short-Term ; Mental Recall ; Metabolites ; Middle Aged ; Neuropsychological Tests ; Nuclear magnetic resonance spectroscopy ; Patients ; Predictive Value of Tests ; Prefrontal Cortex - metabolism ; Proton Magnetic Resonance Spectroscopy ; Risk Factors ; Stroke ; Stroke (Disease)</subject><ispartof>Age and ageing, 2014-09, Vol.43 (5), p.681-686</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Sep 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-6404910c9d5684314b87c88177da2867e64b9f8ee9ebce2a0376a4843047270e3</citedby><cites>FETCH-LOGICAL-c431t-6404910c9d5684314b87c88177da2867e64b9f8ee9ebce2a0376a4843047270e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904,30978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24614642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Dong</creatorcontrib><creatorcontrib>Zhang, Junjian</creatorcontrib><creatorcontrib>Fan, Yuanteng</creatorcontrib><creatorcontrib>Liu, Xuan</creatorcontrib><creatorcontrib>Gao, Yongzhe</creatorcontrib><creatorcontrib>Wu, Guangyao</creatorcontrib><creatorcontrib>Yan, Yatao</creatorcontrib><creatorcontrib>Zeng, Junjie</creatorcontrib><title>Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment.
a group of 54 stroke-free subjects with various VRFs underwent comprehensive cognitive assessments and (1)H MRS scan of the left hippocampus and prefrontal cortex. We indirectly measured the concentrations of N-acetylaspartate (NAA), choline, inositol, creatine (Cr) and total concentrations of glutamate plus glutamine (Glx). VRFs were quantified by Framingham stroke risk profile (FSRP) score. Subjects were divided into low- (<10%), medium- (10-20%) and high-risk (>20%) groups according to their FSRP scores. Pearson and partial correlation analysis were used to investigate the correlation between FSRP scores and cognitive performance along with the brain metabolism.
compared with subjects in low-risk group, high-risk group subjects had significantly poor performances on the tasks of working memory, delayed recall and executive function. In high-risk group, hippocampal Glx/Cr ratios and prefrontal NAA/Cr ratios were significantly lower than those in low-risk group. Lower prefrontal NAA/Cr ratios were associated with executive dysfunction, and lower hippocampal Glx/Cr ratios were associated with impaired delayed recall.
abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by (1)H MRS may serve as important markers for monitoring VRFs burden.</description><subject>Aged</subject><subject>Analysis</subject><subject>Biomarkers - metabolism</subject><subject>Brain</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Cerebrovascular Disorders - diagnosis</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Cognition</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognition Disorders - psychology</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Executive Function</subject><subject>Female</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamine</subject><subject>Glutamine - metabolism</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Memory, Short-Term</subject><subject>Mental Recall</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Patients</subject><subject>Predictive Value of Tests</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqF0U2LFDEQBuAgijuuHr1KwIuXdpN0Oh_HYfALFvai55DOVLfZTSdjkh7dk3_dDLMqePFUVPFQVPEi9JKSt5To_srO4ON8ZaeVMPkIbSgXqmOq54_RhhDCOiKZvkDPSrltLR0oe4ouGBfNcbZBP7djTHmxAQc4Qig4TXjM1ke8QLVjCr5CwYu9b_3e2wrYpTn66o-A_XKwPi8QK26-1JzuoJsyAD7Y6tu44O--fsUOMow5HW1xa7AZZ1_u8GRdTbk8R08mGwq8eKiX6Mv7d593H7vrmw-fdtvrzvGe1k5wwjUlTu8HodqEj0o6paiUe8uUkCD4qCcFoGF0wCzppbC8ScIlkwT6S_TmvPeQ07cVSjWLLw5CsBHSWgwVmmshlZL_p8MgiaJ8oI2-_ofepjXH9shJaSK5YifVndVsAxgfXYoVflSXQoAZTPtzd2O2vWaKUM7EX-9yKiXDZA7ZLzbfG0rMKXRzDt2cQ2_-1cMV69hS-qN_p9z_Ai-FqXc</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Sun, Dong</creator><creator>Zhang, Junjian</creator><creator>Fan, Yuanteng</creator><creator>Liu, Xuan</creator><creator>Gao, Yongzhe</creator><creator>Wu, Guangyao</creator><creator>Yan, Yatao</creator><creator>Zeng, Junjie</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors</title><author>Sun, Dong ; Zhang, Junjian ; Fan, Yuanteng ; Liu, Xuan ; Gao, Yongzhe ; Wu, Guangyao ; Yan, Yatao ; Zeng, Junjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-6404910c9d5684314b87c88177da2867e64b9f8ee9ebce2a0376a4843047270e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Biomarkers - metabolism</topic><topic>Brain</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Cerebrovascular Disorders - diagnosis</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Cognition</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - metabolism</topic><topic>Cognition Disorders - psychology</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Executive Function</topic><topic>Female</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamine</topic><topic>Glutamine - metabolism</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Memory, Short-Term</topic><topic>Mental Recall</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Nuclear magnetic resonance spectroscopy</topic><topic>Patients</topic><topic>Predictive Value of Tests</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Proton Magnetic Resonance Spectroscopy</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Dong</creatorcontrib><creatorcontrib>Zhang, Junjian</creatorcontrib><creatorcontrib>Fan, Yuanteng</creatorcontrib><creatorcontrib>Liu, Xuan</creatorcontrib><creatorcontrib>Gao, Yongzhe</creatorcontrib><creatorcontrib>Wu, Guangyao</creatorcontrib><creatorcontrib>Yan, Yatao</creatorcontrib><creatorcontrib>Zeng, Junjie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Dong</au><au>Zhang, Junjian</au><au>Fan, Yuanteng</au><au>Liu, Xuan</au><au>Gao, Yongzhe</au><au>Wu, Guangyao</au><au>Yan, Yatao</au><au>Zeng, Junjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>43</volume><issue>5</issue><spage>681</spage><epage>686</epage><pages>681-686</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>conventional vascular risk factors (VRFs) are associated with cognitive impairment independent of stroke and detectable cerebral lesions. We used proton magnetic resonance spectroscopy ((1)H MRS) to examine the hypotheses that abnormal levels of brain metabolites may mediate the relationship between VRFs and cognitive impairment.
a group of 54 stroke-free subjects with various VRFs underwent comprehensive cognitive assessments and (1)H MRS scan of the left hippocampus and prefrontal cortex. We indirectly measured the concentrations of N-acetylaspartate (NAA), choline, inositol, creatine (Cr) and total concentrations of glutamate plus glutamine (Glx). VRFs were quantified by Framingham stroke risk profile (FSRP) score. Subjects were divided into low- (<10%), medium- (10-20%) and high-risk (>20%) groups according to their FSRP scores. Pearson and partial correlation analysis were used to investigate the correlation between FSRP scores and cognitive performance along with the brain metabolism.
compared with subjects in low-risk group, high-risk group subjects had significantly poor performances on the tasks of working memory, delayed recall and executive function. In high-risk group, hippocampal Glx/Cr ratios and prefrontal NAA/Cr ratios were significantly lower than those in low-risk group. Lower prefrontal NAA/Cr ratios were associated with executive dysfunction, and lower hippocampal Glx/Cr ratios were associated with impaired delayed recall.
abnormal concentrations of brain metabolites and decreased glutamate plus glutamine concentration may play an important role in the pathophysiology of VRF-associated cognitive impairment. Brain metabolites detected by (1)H MRS may serve as important markers for monitoring VRFs burden.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>24614642</pmid><doi>10.1093/ageing/afu027</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-0729 |
| ispartof | Age and ageing, 2014-09, Vol.43 (5), p.681-686 |
| issn | 0002-0729 1468-2834 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1694967887 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Oxford Journals - Connect here FIRST to enable access; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Analysis Biomarkers - metabolism Brain Cardiovascular disease Care and treatment Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - etiology Cognition Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - psychology Correlation analysis Cross-Sectional Studies Executive Function Female Glutamic Acid - metabolism Glutamine Glutamine - metabolism Hippocampus - metabolism Humans Male Memory, Short-Term Mental Recall Metabolites Middle Aged Neuropsychological Tests Nuclear magnetic resonance spectroscopy Patients Predictive Value of Tests Prefrontal Cortex - metabolism Proton Magnetic Resonance Spectroscopy Risk Factors Stroke Stroke (Disease) |
| title | Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T14%3A48%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Abnormal%20levels%20of%20brain%20metabolites%20may%20mediate%20cognitive%20impairment%20in%20stroke-free%20patients%20with%20cerebrovascular%20risk%20factors&rft.jtitle=Age%20and%20ageing&rft.au=Sun,%20Dong&rft.date=2014-09-01&rft.volume=43&rft.issue=5&rft.spage=681&rft.epage=686&rft.pages=681-686&rft.issn=0002-0729&rft.eissn=1468-2834&rft.coden=AANGAH&rft_id=info:doi/10.1093/ageing/afu027&rft_dat=%3Cgale_proqu%3EA392801426%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1559074821&rft_id=info:pmid/24614642&rft_galeid=A392801426&rfr_iscdi=true |