Beyond BRCA : New hereditary breast cancer susceptibility genes
Highlights • Sequencing of specific genes can identify families at risk of breast cancer. • Multigene panel testing should be performed after consultation with a cancer geneticist. • There is no consensus on when to use expanded models of testing. • High penetrant breast cancer genes include TP53, P...
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| Veröffentlicht in: | Cancer treatment reviews 2015-01, Vol.41 (1), p.1-8 |
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| container_title | Cancer treatment reviews |
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| creator | Economopoulou, P Dimitriadis, G Psyrri, A |
| description | Highlights • Sequencing of specific genes can identify families at risk of breast cancer. • Multigene panel testing should be performed after consultation with a cancer geneticist. • There is no consensus on when to use expanded models of testing. • High penetrant breast cancer genes include TP53, PTEN, SKT-11, CDH1 and PALB2. |
| doi_str_mv | 10.1016/j.ctrv.2014.10.008 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0305-7372 |
| ispartof | Cancer treatment reviews, 2015-01, Vol.41 (1), p.1-8 |
| issn | 0305-7372 1532-1967 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biomarkers, Tumor - genetics BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer susceptibility genes Breast Neoplasms - genetics Early Detection of Cancer Female Genes, Neoplasm Genetic Markers Genetic Predisposition to Disease - genetics Genetic Testing - methods Hematology, Oncology and Palliative Medicine Hereditary breast cancer Humans Neoplasm Proteins - genetics PALB2 PTEN TP53 |
| title | Beyond BRCA : New hereditary breast cancer susceptibility genes |
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