Beyond BRCA : New hereditary breast cancer susceptibility genes

Highlights • Sequencing of specific genes can identify families at risk of breast cancer. • Multigene panel testing should be performed after consultation with a cancer geneticist. • There is no consensus on when to use expanded models of testing. • High penetrant breast cancer genes include TP53, P...

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Veröffentlicht in:	Cancer treatment reviews 2015-01, Vol.41 (1), p.1-8
Hauptverfasser:	Economopoulou, P, Dimitriadis, G, Psyrri, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer susceptibility genes Breast Neoplasms - genetics Early Detection of Cancer Female Genes, Neoplasm Genetic Markers Genetic Predisposition to Disease - genetics Genetic Testing - methods Hematology, Oncology and Palliative Medicine Hereditary breast cancer Humans Neoplasm Proteins - genetics PALB2 PTEN TP53
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Zusammenfassung:	Highlights • Sequencing of specific genes can identify families at risk of breast cancer. • Multigene panel testing should be performed after consultation with a cancer geneticist. • There is no consensus on when to use expanded models of testing. • High penetrant breast cancer genes include TP53, PTEN, SKT-11, CDH1 and PALB2.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2014.10.008