Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution
Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on...
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| Veröffentlicht in: | Clinical cancer research 2013-07, Vol.19 (14), p.3966-3976 |
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| creator | SEMINO-MORA, Cristina TESTERMAN, Traci L MERRELL, D. Scott DUBOIS, Andre HUI LIU WHITMIRE, Jeannette M STUDEMAN, Kimberley YALI JIA McAVOY, Thomas J FRANCIS, Jennifer NIERODA, Carol SARDI, Armando |
| description | Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and β-catenin expression within pseudomyxoma peritonei samples.
The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA). Fourteen patients were given antibiotics (30 mg lansoprazole, 1 g amoxicillin, and 500 mg clarithromycin) twice a day for 14 days. One week after completion of therapy, surgery was conducted and specimens were harvested for pathology, bacterial culture, ISH, and immunohistochemistry.
ISH showed the presence of bacteria in 83% of the patient samples, with a higher Helicobacter pylori density observed in PMCA versus DPAM. PMCA patients treated with antibiotics had a significantly lower bacterial density and decreased β-catenin levels in the cytoplasm, the cell nuclei, and mucin-associated cells. Although not significant, similar trends were observed in DPAM patients. Cell membrane β-catenin was significantly increased in both DPAM and PMCA patients receiving antibiotics.
Bacteria play an important role in pseudomyxoma peritonei. Antibiotic treatment improved the histopathology of tissue, particularly in PMCA patients. In PMCA, antibiotics decreased bacterial density and were associated with a significant β-catenin decrease in the cytoplasm, cell nuclei, and mucin along with a small membrane increase. These results suggest that antibiotics offer potential protection against cell detachment, cellular invasion, and metastasis. |
| doi_str_mv | 10.1158/1078-0432.CCR-13-0616 |
| format | Article |
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The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA). Fourteen patients were given antibiotics (30 mg lansoprazole, 1 g amoxicillin, and 500 mg clarithromycin) twice a day for 14 days. One week after completion of therapy, surgery was conducted and specimens were harvested for pathology, bacterial culture, ISH, and immunohistochemistry.
ISH showed the presence of bacteria in 83% of the patient samples, with a higher Helicobacter pylori density observed in PMCA versus DPAM. PMCA patients treated with antibiotics had a significantly lower bacterial density and decreased β-catenin levels in the cytoplasm, the cell nuclei, and mucin-associated cells. Although not significant, similar trends were observed in DPAM patients. Cell membrane β-catenin was significantly increased in both DPAM and PMCA patients receiving antibiotics.
Bacteria play an important role in pseudomyxoma peritonei. Antibiotic treatment improved the histopathology of tissue, particularly in PMCA patients. In PMCA, antibiotics decreased bacterial density and were associated with a significant β-catenin decrease in the cytoplasm, cell nuclei, and mucin along with a small membrane increase. These results suggest that antibiotics offer potential protection against cell detachment, cellular invasion, and metastasis.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-13-0616</identifier><identifier>PMID: 23743566</identifier><identifier>CODEN: CCREF4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Abdomen ; Adenocarcinoma, Mucinous - drug therapy ; Adenocarcinoma, Mucinous - microbiology ; Adenocarcinoma, Mucinous - surgery ; Amoxicillin - pharmacology ; Amoxicillin - therapeutic use ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antineoplastic agents ; Bacterial Load - drug effects ; beta Catenin - metabolism ; Biological and medical sciences ; Cell Membrane - metabolism ; Cell Nucleus ; Clarithromycin - pharmacology ; Clarithromycin - therapeutic use ; Combined Modality Therapy ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - drug therapy ; Helicobacter pylori ; Helicobacter pylori - genetics ; Humans ; In Situ Hybridization ; Lansoprazole - pharmacology ; Lansoprazole - therapeutic use ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Peritoneal Neoplasms - drug therapy ; Peritoneal Neoplasms - microbiology ; Peritoneal Neoplasms - surgery ; Pharmacology. Drug treatments ; Protein Transport ; Pseudomyxoma Peritonei - drug therapy ; Pseudomyxoma Peritonei - microbiology ; Pseudomyxoma Peritonei - surgery ; Treatment Outcome</subject><ispartof>Clinical cancer research, 2013-07, Vol.19 (14), p.3966-3976</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-aa5e9c55e2045bcbf39d69cb8989482c6d979f7c4440cce6bd922457a5d89b763</citedby><cites>FETCH-LOGICAL-c419t-aa5e9c55e2045bcbf39d69cb8989482c6d979f7c4440cce6bd922457a5d89b763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3356,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27947817$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23743566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SEMINO-MORA, Cristina</creatorcontrib><creatorcontrib>TESTERMAN, Traci L</creatorcontrib><creatorcontrib>MERRELL, D. Scott</creatorcontrib><creatorcontrib>DUBOIS, Andre</creatorcontrib><creatorcontrib>HUI LIU</creatorcontrib><creatorcontrib>WHITMIRE, Jeannette M</creatorcontrib><creatorcontrib>STUDEMAN, Kimberley</creatorcontrib><creatorcontrib>YALI JIA</creatorcontrib><creatorcontrib>McAVOY, Thomas J</creatorcontrib><creatorcontrib>FRANCIS, Jennifer</creatorcontrib><creatorcontrib>NIERODA, Carol</creatorcontrib><creatorcontrib>SARDI, Armando</creatorcontrib><title>Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and β-catenin expression within pseudomyxoma peritonei samples.
The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA). Fourteen patients were given antibiotics (30 mg lansoprazole, 1 g amoxicillin, and 500 mg clarithromycin) twice a day for 14 days. One week after completion of therapy, surgery was conducted and specimens were harvested for pathology, bacterial culture, ISH, and immunohistochemistry.
ISH showed the presence of bacteria in 83% of the patient samples, with a higher Helicobacter pylori density observed in PMCA versus DPAM. PMCA patients treated with antibiotics had a significantly lower bacterial density and decreased β-catenin levels in the cytoplasm, the cell nuclei, and mucin-associated cells. Although not significant, similar trends were observed in DPAM patients. Cell membrane β-catenin was significantly increased in both DPAM and PMCA patients receiving antibiotics.
Bacteria play an important role in pseudomyxoma peritonei. Antibiotic treatment improved the histopathology of tissue, particularly in PMCA patients. In PMCA, antibiotics decreased bacterial density and were associated with a significant β-catenin decrease in the cytoplasm, cell nuclei, and mucin along with a small membrane increase. These results suggest that antibiotics offer potential protection against cell detachment, cellular invasion, and metastasis.</description><subject>Abdomen</subject><subject>Adenocarcinoma, Mucinous - drug therapy</subject><subject>Adenocarcinoma, Mucinous - microbiology</subject><subject>Adenocarcinoma, Mucinous - surgery</subject><subject>Amoxicillin - pharmacology</subject><subject>Amoxicillin - therapeutic use</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>Bacterial Load - drug effects</subject><subject>beta Catenin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - metabolism</subject><subject>Cell Nucleus</subject><subject>Clarithromycin - pharmacology</subject><subject>Clarithromycin - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - genetics</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Lansoprazole - pharmacology</subject><subject>Lansoprazole - therapeutic use</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Peritoneal Neoplasms - drug therapy</subject><subject>Peritoneal Neoplasms - microbiology</subject><subject>Peritoneal Neoplasms - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Transport</subject><subject>Pseudomyxoma Peritonei - drug therapy</subject><subject>Pseudomyxoma Peritonei - microbiology</subject><subject>Pseudomyxoma Peritonei - surgery</subject><subject>Treatment Outcome</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhi0Eohd4BJA3SGxS7PgWLw8pFKQiKlTWli8TYZTYxXYE5bF4EJ6JHPUUlqxmFt8_I_0fQs8oOaNUDK8oUUNHOOvPxvFTR1lHJJUP0DEVQnWsl-Lhtt8zR-ik1q-EUE4Jf4yOeqY4E1Ieo5-71KKLuUWPrwvYtkBq-Bz8tleo-EP0JbtoZ_x6LQES3tWafbQNAv4e2xd8VWENebn9kReLr6DElhNEbFPAu2kC3yr-_asbt0CKCZ_H2kp0a4s5PUGPJjtXeHqYp-jz2zfX47vu8uPF-3F32XlOdeusFaC9ENATLpx3E9NBau8GPWg-9F4GrfSkPOeceA_SBd33XCgrwqCdkuwUvby7e1PytxVqM0usHubZJshrNVRqrqUiov8_ygklmsiBbKi4Q7d-ai0wmZsSF1tuDSVmb8js2zf79s1myFBm9oa23PPDi9UtEP6m7pVswIsDYKu381Rs8rH-45TmaqCK_QH9m5ta</recordid><startdate>20130715</startdate><enddate>20130715</enddate><creator>SEMINO-MORA, Cristina</creator><creator>TESTERMAN, Traci L</creator><creator>MERRELL, D. Scott</creator><creator>DUBOIS, Andre</creator><creator>HUI LIU</creator><creator>WHITMIRE, Jeannette M</creator><creator>STUDEMAN, Kimberley</creator><creator>YALI JIA</creator><creator>McAVOY, Thomas J</creator><creator>FRANCIS, Jennifer</creator><creator>NIERODA, Carol</creator><creator>SARDI, Armando</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130715</creationdate><title>Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution</title><author>SEMINO-MORA, Cristina ; TESTERMAN, Traci L ; MERRELL, D. Scott ; DUBOIS, Andre ; HUI LIU ; WHITMIRE, Jeannette M ; STUDEMAN, Kimberley ; YALI JIA ; McAVOY, Thomas J ; FRANCIS, Jennifer ; NIERODA, Carol ; SARDI, Armando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-aa5e9c55e2045bcbf39d69cb8989482c6d979f7c4440cce6bd922457a5d89b763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdomen</topic><topic>Adenocarcinoma, Mucinous - drug therapy</topic><topic>Adenocarcinoma, Mucinous - microbiology</topic><topic>Adenocarcinoma, Mucinous - surgery</topic><topic>Amoxicillin - pharmacology</topic><topic>Amoxicillin - therapeutic use</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>Bacterial Load - drug effects</topic><topic>beta Catenin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - metabolism</topic><topic>Cell Nucleus</topic><topic>Clarithromycin - pharmacology</topic><topic>Clarithromycin - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - genetics</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Lansoprazole - pharmacology</topic><topic>Lansoprazole - therapeutic use</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Peritoneal Neoplasms - drug therapy</topic><topic>Peritoneal Neoplasms - microbiology</topic><topic>Peritoneal Neoplasms - surgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Transport</topic><topic>Pseudomyxoma Peritonei - drug therapy</topic><topic>Pseudomyxoma Peritonei - microbiology</topic><topic>Pseudomyxoma Peritonei - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SEMINO-MORA, Cristina</creatorcontrib><creatorcontrib>TESTERMAN, Traci L</creatorcontrib><creatorcontrib>MERRELL, D. Scott</creatorcontrib><creatorcontrib>DUBOIS, Andre</creatorcontrib><creatorcontrib>HUI LIU</creatorcontrib><creatorcontrib>WHITMIRE, Jeannette M</creatorcontrib><creatorcontrib>STUDEMAN, Kimberley</creatorcontrib><creatorcontrib>YALI JIA</creatorcontrib><creatorcontrib>McAVOY, Thomas J</creatorcontrib><creatorcontrib>FRANCIS, Jennifer</creatorcontrib><creatorcontrib>NIERODA, Carol</creatorcontrib><creatorcontrib>SARDI, Armando</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SEMINO-MORA, Cristina</au><au>TESTERMAN, Traci L</au><au>MERRELL, D. Scott</au><au>DUBOIS, Andre</au><au>HUI LIU</au><au>WHITMIRE, Jeannette M</au><au>STUDEMAN, Kimberley</au><au>YALI JIA</au><au>McAVOY, Thomas J</au><au>FRANCIS, Jennifer</au><au>NIERODA, Carol</au><au>SARDI, Armando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2013-07-15</date><risdate>2013</risdate><volume>19</volume><issue>14</issue><spage>3966</spage><epage>3976</epage><pages>3966-3976</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><coden>CCREF4</coden><abstract>Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and β-catenin expression within pseudomyxoma peritonei samples.
The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA). Fourteen patients were given antibiotics (30 mg lansoprazole, 1 g amoxicillin, and 500 mg clarithromycin) twice a day for 14 days. One week after completion of therapy, surgery was conducted and specimens were harvested for pathology, bacterial culture, ISH, and immunohistochemistry.
ISH showed the presence of bacteria in 83% of the patient samples, with a higher Helicobacter pylori density observed in PMCA versus DPAM. PMCA patients treated with antibiotics had a significantly lower bacterial density and decreased β-catenin levels in the cytoplasm, the cell nuclei, and mucin-associated cells. Although not significant, similar trends were observed in DPAM patients. Cell membrane β-catenin was significantly increased in both DPAM and PMCA patients receiving antibiotics.
Bacteria play an important role in pseudomyxoma peritonei. Antibiotic treatment improved the histopathology of tissue, particularly in PMCA patients. In PMCA, antibiotics decreased bacterial density and were associated with a significant β-catenin decrease in the cytoplasm, cell nuclei, and mucin along with a small membrane increase. These results suggest that antibiotics offer potential protection against cell detachment, cellular invasion, and metastasis.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>23743566</pmid><doi>10.1158/1078-0432.CCR-13-0616</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cancer research, 2013-07, Vol.19 (14), p.3966-3976 |
| issn | 1078-0432 1557-3265 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Abdomen Adenocarcinoma, Mucinous - drug therapy Adenocarcinoma, Mucinous - microbiology Adenocarcinoma, Mucinous - surgery Amoxicillin - pharmacology Amoxicillin - therapeutic use Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antineoplastic agents Bacterial Load - drug effects beta Catenin - metabolism Biological and medical sciences Cell Membrane - metabolism Cell Nucleus Clarithromycin - pharmacology Clarithromycin - therapeutic use Combined Modality Therapy Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - drug therapy Helicobacter pylori Helicobacter pylori - genetics Humans In Situ Hybridization Lansoprazole - pharmacology Lansoprazole - therapeutic use Medical sciences Middle Aged Other diseases. Semiology Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - microbiology Peritoneal Neoplasms - surgery Pharmacology. Drug treatments Protein Transport Pseudomyxoma Peritonei - drug therapy Pseudomyxoma Peritonei - microbiology Pseudomyxoma Peritonei - surgery Treatment Outcome |
| title | Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution |
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