Progress in cell-based therapies for tendon repair
The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. In vitro studies assess the influence of biophysical, biochemical and biological signals on tenogenic phen...
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| Veröffentlicht in: | Advanced drug delivery reviews 2015-04, Vol.84, p.240-256 |
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| creator | Gaspar, Diana Spanoudes, Kyriakos Holladay, Carolyn Pandit, Abhay Zeugolis, Dimitrios |
| description | The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. In vitro studies assess the influence of biophysical, biochemical and biological signals on tenogenic phenotype maintenance and/or differentiation towards tenogenic lineage. However, the ideal culture environment has yet to be identified due to the lack of standardised experimental setup and readout system. Bone marrow mesenchymal stem cells and tenocytes/dermal fibroblasts appear to be the cell populations of choice for clinical translation in equine and human patients respectively based on circumstantial, rather than on hard evidence. Collaborative, inter- and multi-disciplinary efforts are expected to provide clinically relevant and commercially viable cell-based therapies for tendon repair and regeneration in the years to come.
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| doi_str_mv | 10.1016/j.addr.2014.11.023 |
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[Display omitted]</description><subject>Animals</subject><subject>Cell Culture Techniques - methods</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Cell- and Tissue-Based Therapy - veterinary</subject><subject>Cell-based therapy</subject><subject>Clinical trials</subject><subject>Humans</subject><subject>In vitro microenvironment modulators</subject><subject>Permanently differentiated cells</subject><subject>Regeneration - physiology</subject><subject>Reprogrammed/engineered cells</subject><subject>Small/large animal preclinical models</subject><subject>Stem cells</subject><subject>Tendon repair and regeneration</subject><subject>Tendons - physiology</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQRpYEn2PHicSCKr6kSjCAxGY59hlctUmwUyT-Pa5aGJluuOdevfcQcg60AArV1bLQ1oaCUeAFQEFZeUCmUEuW16zhh2SaoCbntHmbkJMYl5QCkxU9JhMmBC8pFVPCnkP_HjDGzHeZwdUqb3VEm40fGPTgMWauD9mIne27LOCgfTglR06vIp7t54y83t2-zB_yxdP94_xmkRvOqjGvKXWlE4wzaAGErESruYW6kYxqJ4SpeZ36ONGmxtKZsgWJVpZtWlqBrpyRy13uEPrPDcZRrX3cVtQd9puo0nO8qUrJ6oSyHWpCH2NAp4bg1zp8K6Bq60ot1daV2rpSACq5SkcX-_xNu0b7d_IrJwHXOwDTl18eg4rGY2fQ-oBmVLb3_-X_AHeDeO8</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Gaspar, Diana</creator><creator>Spanoudes, Kyriakos</creator><creator>Holladay, Carolyn</creator><creator>Pandit, Abhay</creator><creator>Zeugolis, Dimitrios</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Progress in cell-based therapies for tendon repair</title><author>Gaspar, Diana ; Spanoudes, Kyriakos ; Holladay, Carolyn ; Pandit, Abhay ; Zeugolis, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-800f3f52421b115765ba4d189720af55c848127f5b8727fc3b17ed73baf5d5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cell Culture Techniques - methods</topic><topic>Cell- and Tissue-Based Therapy - methods</topic><topic>Cell- and Tissue-Based Therapy - veterinary</topic><topic>Cell-based therapy</topic><topic>Clinical trials</topic><topic>Humans</topic><topic>In vitro microenvironment modulators</topic><topic>Permanently differentiated cells</topic><topic>Regeneration - physiology</topic><topic>Reprogrammed/engineered cells</topic><topic>Small/large animal preclinical models</topic><topic>Stem cells</topic><topic>Tendon repair and regeneration</topic><topic>Tendons - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaspar, Diana</creatorcontrib><creatorcontrib>Spanoudes, Kyriakos</creatorcontrib><creatorcontrib>Holladay, Carolyn</creatorcontrib><creatorcontrib>Pandit, Abhay</creatorcontrib><creatorcontrib>Zeugolis, Dimitrios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaspar, Diana</au><au>Spanoudes, Kyriakos</au><au>Holladay, Carolyn</au><au>Pandit, Abhay</au><au>Zeugolis, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progress in cell-based therapies for tendon repair</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>84</volume><spage>240</spage><epage>256</epage><pages>240-256</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. 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| ispartof | Advanced drug delivery reviews, 2015-04, Vol.84, p.240-256 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Culture Techniques - methods Cell- and Tissue-Based Therapy - methods Cell- and Tissue-Based Therapy - veterinary Cell-based therapy Clinical trials Humans In vitro microenvironment modulators Permanently differentiated cells Regeneration - physiology Reprogrammed/engineered cells Small/large animal preclinical models Stem cells Tendon repair and regeneration Tendons - physiology |
| title | Progress in cell-based therapies for tendon repair |
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