Demyelinating CMT–what’s known, what’s new and what’s in store?

•Charcot–Marie–Tooth disease is common affecting 1 in 2500 people.•Demyelination is observed in two major groups – CMT1 and CMT4.•CMT1A remains the most commonly described CMT across all populations.•CMT4 is typically severe with early onset and associated features, such as scoliosis.•Recent molecul...

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Veröffentlicht in:	Neuroscience letters 2015-06, Vol.596, p.14-26
Hauptverfasser:	Brennan, Kathryn M., Bai, Yunhong, Shy, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Charcot-Marie-Tooth Disease - classification Charcot-Marie-Tooth Disease - genetics Charcot-Marie-Tooth Disease - pathology Charcot–Marie–Tooth disease Cx32 Demyelinating Diseases - classification Demyelinating Diseases - genetics Demyelinating Diseases - pathology Demyelinating neuropathies Humans Inherited neuropathies MPZ Mutation PMP22 Unfolded protein response
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