Efficacy of oxitard capsules in the treatment of oral submucous fibrosis
Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF. Total of 120 subjects with clinico-pathologically diagnosed OSMF were included...
Gespeichert in:
| Veröffentlicht in: | Journal of cancer research and therapeutics 2015-04, Vol.11 (2), p.291-294 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 294 |
|---|---|
| container_issue | 2 |
| container_start_page | 291 |
| container_title | Journal of cancer research and therapeutics |
| container_volume | 11 |
| creator | Patil, Santosh Santosh, B S Maheshwari, Sneha Deoghare, Abhijeet Chhugani, Satish Rajesh, P R |
| description | Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF.
Total of 120 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups; Group A (oxitard group) and Group B (placebo group). Group A was administered 2 oxitard capsules twice daily and Group B was given placebo tablets twice daily, for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P < 0.001 was considered to be statistically significant.
Clinical improvements in mouth-opening and tongue protrusion were significant in the Group A (P < 0.001). Subjective symptoms of burning sensation (P = 0.0001), pain associated with the lesion (P = 0.000), difficulty in swallowing (P = 0.0003) and speech (P = 0.0005) also significantly improved in the Group A. There was a mild to moderate decrease in the size of the lesion.
Though there is no definitive treatment for the condition; however, oxitard capsules can bring about significant clinical improvements in the symptoms like mouth-opening, tongue protrusion, burning sensation, difficulty in swallowing and speech and pain associated with the lesion, thereby improving the quality of life of the affected individuals. |
| doi_str_mv | 10.4103/0973-1482.136023 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694961517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A421598484</galeid><sourcerecordid>A421598484</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a29dfe4670cfb3e8c2350edcb1739785f7037f41cbc338db95a4d0d9edc5a1e83</originalsourceid><addsrcrecordid>eNptkc9LBCEUxyWK2rbunWKgS5fZdNRRjxHVBkGXOovjPDdjfmw6A_Xf57QVFYsH4fn5Pp7vg9AJwQtGML3AStCcMFksCC1xQXfQjCglc0ao3EWzn-cDdBjjC8ZcFIXcRwdFmapcihlaXjvnrbHvWe-y_s0PJtSZNes4NhAz32XDM2RDADO00A2fUDBNFseqHW0_xsz5KvTRxyO050wT4fjrnqOnm-vHq2V-_3B7d3V5n1sm2JCbQtUOWCmwdRUFaQvKMdS2IoIqIbkTmArHiK0spbKuFDesxrVKCDcEJJ2j803fdehfR4iDbn200DSmgzSPJqViqiQ89Zujs3_oSz-GLk03UWUpFae_qJVpQPvO9UMwdmqqL1lBuJJMskTlW6gVdJDW0XfgfCr_4Rdb-HRqaL3dGsCbgE3rjAGcXgffmvCuCdaTbD3Z1JNNvZGdIqdf_0s2oP4JfNulHyTkoe8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1696689537</pqid></control><display><type>article</type><title>Efficacy of oxitard capsules in the treatment of oral submucous fibrosis</title><source>MEDLINE</source><source>Medknow Open Access Medical Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Patil, Santosh ; Santosh, B S ; Maheshwari, Sneha ; Deoghare, Abhijeet ; Chhugani, Satish ; Rajesh, P R</creator><creatorcontrib>Patil, Santosh ; Santosh, B S ; Maheshwari, Sneha ; Deoghare, Abhijeet ; Chhugani, Satish ; Rajesh, P R</creatorcontrib><description>Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF.
Total of 120 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups; Group A (oxitard group) and Group B (placebo group). Group A was administered 2 oxitard capsules twice daily and Group B was given placebo tablets twice daily, for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P < 0.001 was considered to be statistically significant.
Clinical improvements in mouth-opening and tongue protrusion were significant in the Group A (P < 0.001). Subjective symptoms of burning sensation (P = 0.0001), pain associated with the lesion (P = 0.000), difficulty in swallowing (P = 0.0003) and speech (P = 0.0005) also significantly improved in the Group A. There was a mild to moderate decrease in the size of the lesion.
Though there is no definitive treatment for the condition; however, oxitard capsules can bring about significant clinical improvements in the symptoms like mouth-opening, tongue protrusion, burning sensation, difficulty in swallowing and speech and pain associated with the lesion, thereby improving the quality of life of the affected individuals.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.136023</identifier><identifier>PMID: 26148587</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Adult ; Antibiotics ; Antioxidants (Nutrients) ; Capsules ; Care and treatment ; Cell division ; Disease ; Family medical history ; Female ; Fibrosis ; Health aspects ; Humans ; Male ; Metabolic disorders ; Mouth ; Oral Submucous Fibrosis - drug therapy ; Oral Submucous Fibrosis - etiology ; Oral Submucous Fibrosis - pathology ; Pain ; Plant Extracts - administration & dosage ; Speech ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of cancer research and therapeutics, 2015-04, Vol.11 (2), p.291-294</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Apr-Jun 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a29dfe4670cfb3e8c2350edcb1739785f7037f41cbc338db95a4d0d9edc5a1e83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26148587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patil, Santosh</creatorcontrib><creatorcontrib>Santosh, B S</creatorcontrib><creatorcontrib>Maheshwari, Sneha</creatorcontrib><creatorcontrib>Deoghare, Abhijeet</creatorcontrib><creatorcontrib>Chhugani, Satish</creatorcontrib><creatorcontrib>Rajesh, P R</creatorcontrib><title>Efficacy of oxitard capsules in the treatment of oral submucous fibrosis</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF.
Total of 120 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups; Group A (oxitard group) and Group B (placebo group). Group A was administered 2 oxitard capsules twice daily and Group B was given placebo tablets twice daily, for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P < 0.001 was considered to be statistically significant.
Clinical improvements in mouth-opening and tongue protrusion were significant in the Group A (P < 0.001). Subjective symptoms of burning sensation (P = 0.0001), pain associated with the lesion (P = 0.000), difficulty in swallowing (P = 0.0003) and speech (P = 0.0005) also significantly improved in the Group A. There was a mild to moderate decrease in the size of the lesion.
Though there is no definitive treatment for the condition; however, oxitard capsules can bring about significant clinical improvements in the symptoms like mouth-opening, tongue protrusion, burning sensation, difficulty in swallowing and speech and pain associated with the lesion, thereby improving the quality of life of the affected individuals.</description><subject>Adult</subject><subject>Antibiotics</subject><subject>Antioxidants (Nutrients)</subject><subject>Capsules</subject><subject>Care and treatment</subject><subject>Cell division</subject><subject>Disease</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Mouth</subject><subject>Oral Submucous Fibrosis - drug therapy</subject><subject>Oral Submucous Fibrosis - etiology</subject><subject>Oral Submucous Fibrosis - pathology</subject><subject>Pain</subject><subject>Plant Extracts - administration & dosage</subject><subject>Speech</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc9LBCEUxyWK2rbunWKgS5fZdNRRjxHVBkGXOovjPDdjfmw6A_Xf57QVFYsH4fn5Pp7vg9AJwQtGML3AStCcMFksCC1xQXfQjCglc0ao3EWzn-cDdBjjC8ZcFIXcRwdFmapcihlaXjvnrbHvWe-y_s0PJtSZNes4NhAz32XDM2RDADO00A2fUDBNFseqHW0_xsz5KvTRxyO050wT4fjrnqOnm-vHq2V-_3B7d3V5n1sm2JCbQtUOWCmwdRUFaQvKMdS2IoIqIbkTmArHiK0spbKuFDesxrVKCDcEJJ2j803fdehfR4iDbn200DSmgzSPJqViqiQ89Zujs3_oSz-GLk03UWUpFae_qJVpQPvO9UMwdmqqL1lBuJJMskTlW6gVdJDW0XfgfCr_4Rdb-HRqaL3dGsCbgE3rjAGcXgffmvCuCdaTbD3Z1JNNvZGdIqdf_0s2oP4JfNulHyTkoe8</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Patil, Santosh</creator><creator>Santosh, B S</creator><creator>Maheshwari, Sneha</creator><creator>Deoghare, Abhijeet</creator><creator>Chhugani, Satish</creator><creator>Rajesh, P R</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Efficacy of oxitard capsules in the treatment of oral submucous fibrosis</title><author>Patil, Santosh ; Santosh, B S ; Maheshwari, Sneha ; Deoghare, Abhijeet ; Chhugani, Satish ; Rajesh, P R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a29dfe4670cfb3e8c2350edcb1739785f7037f41cbc338db95a4d0d9edc5a1e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Antibiotics</topic><topic>Antioxidants (Nutrients)</topic><topic>Capsules</topic><topic>Care and treatment</topic><topic>Cell division</topic><topic>Disease</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Mouth</topic><topic>Oral Submucous Fibrosis - drug therapy</topic><topic>Oral Submucous Fibrosis - etiology</topic><topic>Oral Submucous Fibrosis - pathology</topic><topic>Pain</topic><topic>Plant Extracts - administration & dosage</topic><topic>Speech</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patil, Santosh</creatorcontrib><creatorcontrib>Santosh, B S</creatorcontrib><creatorcontrib>Maheshwari, Sneha</creatorcontrib><creatorcontrib>Deoghare, Abhijeet</creatorcontrib><creatorcontrib>Chhugani, Satish</creatorcontrib><creatorcontrib>Rajesh, P R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patil, Santosh</au><au>Santosh, B S</au><au>Maheshwari, Sneha</au><au>Deoghare, Abhijeet</au><au>Chhugani, Satish</au><au>Rajesh, P R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of oxitard capsules in the treatment of oral submucous fibrosis</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>11</volume><issue>2</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Oral submucous fibrosis (OSMF) is a high-risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to evaluate the efficacy of oxitard capsules in the management of OSMF.
Total of 120 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups; Group A (oxitard group) and Group B (placebo group). Group A was administered 2 oxitard capsules twice daily and Group B was given placebo tablets twice daily, for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P < 0.001 was considered to be statistically significant.
Clinical improvements in mouth-opening and tongue protrusion were significant in the Group A (P < 0.001). Subjective symptoms of burning sensation (P = 0.0001), pain associated with the lesion (P = 0.000), difficulty in swallowing (P = 0.0003) and speech (P = 0.0005) also significantly improved in the Group A. There was a mild to moderate decrease in the size of the lesion.
Though there is no definitive treatment for the condition; however, oxitard capsules can bring about significant clinical improvements in the symptoms like mouth-opening, tongue protrusion, burning sensation, difficulty in swallowing and speech and pain associated with the lesion, thereby improving the quality of life of the affected individuals.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>26148587</pmid><doi>10.4103/0973-1482.136023</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0973-1482 |
| ispartof | Journal of cancer research and therapeutics, 2015-04, Vol.11 (2), p.291-294 |
| issn | 0973-1482 1998-4138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1694961517 |
| source | MEDLINE; Medknow Open Access Medical Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antibiotics Antioxidants (Nutrients) Capsules Care and treatment Cell division Disease Family medical history Female Fibrosis Health aspects Humans Male Metabolic disorders Mouth Oral Submucous Fibrosis - drug therapy Oral Submucous Fibrosis - etiology Oral Submucous Fibrosis - pathology Pain Plant Extracts - administration & dosage Speech Treatment Outcome Young Adult |
| title | Efficacy of oxitard capsules in the treatment of oral submucous fibrosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T14%3A25%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20oxitard%20capsules%20in%20the%20treatment%20of%20oral%20submucous%20fibrosis&rft.jtitle=Journal%20of%20cancer%20research%20and%20therapeutics&rft.au=Patil,%20Santosh&rft.date=2015-04-01&rft.volume=11&rft.issue=2&rft.spage=291&rft.epage=294&rft.pages=291-294&rft.issn=0973-1482&rft.eissn=1998-4138&rft_id=info:doi/10.4103/0973-1482.136023&rft_dat=%3Cgale_proqu%3EA421598484%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1696689537&rft_id=info:pmid/26148587&rft_galeid=A421598484&rfr_iscdi=true |