Long-term treatment with 5,5-diphenylhydantoin reduces lymphadenopathy and anti-ssDNA autoantibodies in C57BL/6- lpr/ lpr mice

To further the insight in the immunomodulating properties of the anticonvulsant 5,5-diphenylhydantoin (DPH), C57BL/6 (B6), C57BL/6- lpr/ lpr (B6- lpr/ lpr) and MRL/MpJ-+/+ (MRL) mice received DPH orally for six months to determine weekly urinary biopterin levels, a potential T-cell activation marker...

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Veröffentlicht in:	International journal of immunopharmacology 1994-03, Vol.16 (3), p.261-268
Hauptverfasser:	Bloksma, N., de Bakker, J.M., van Rooijen, H.J.M., Punt, P., Seinen, W., Kammüller, M.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Antinuclear - drug effects Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Biological and medical sciences Biopterins - urine Body Weight - drug effects Drug Administration Schedule Female Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood immunomodulation Immunomodulators lpr gene Lymphatic Diseases - drug therapy Lymphatic Diseases - immunology Lymphoid Tissue - drug effects Medical sciences Mice Mice, Inbred C57BL Mice, Inbred Strains Organ Size - drug effects Pharmacology. Drug treatments phenytoin Phenytoin - administration & dosage Phenytoin - pharmacology Rheumatoid Factor - drug effects
Online-Zugang:	Volltext
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