Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the loss of nigrostriatal dopaminergic neurons and consequent motor dysfunction. Zonisamide (1,2‐benzisoxazole‐3‐methanesulfonamide), which was originally developed as an antiepileptic drug, has been found to have...

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Veröffentlicht in:	Journal of neurochemistry 2015-07, Vol.134 (2), p.371-381
Hauptverfasser:	Sano, Hiromi, Murata, Miho, Nambu, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antiparkinson Agents - pharmacology Brain - drug effects Brain - metabolism Brain - pathology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Dopamine dopaminergic neurons Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Epilepsy Isoxazoles - pharmacology Male Mice Mice, Inbred C57BL Mice, Mutant Strains Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurodegeneration neuroprotection Neuroprotective Agents - pharmacology neurotrophic factor Parkinson's disease Parkinsonian Disorders - pathology Rodents
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