Accelerated telomere shortening in β-thalassemia/HbE patients

β-Thalassemia/HbE disease is caused by a defective β-globin synthesis that leads to accumulation of excess unbound α-globins, and consequently oxidative stress, ineffective erythropoiesis and chronic anemia. Cell replication and oxidative stress are factors contributing to erosion of telomeres respo...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2015-08, Vol.55 (2), p.173-179
Hauptverfasser:	Chaichompoo, Pornthip, Pattanapanyasat, Kovit, Winichagoon, Pranee, Fucharoen, Suthat, Svasti, Saovaros
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aging alpha-Globins - genetics beta-Globins - genetics beta-Thalassemia - diagnosis beta-Thalassemia - genetics beta-Thalassemia - metabolism Erythrocyte Indices Female Flow-FISH Genotype Hemoglobin E - genetics Humans Male Middle Aged Oxidative Stress Reticulocytosis Severity of Illness Index Telomerase Telomerase - metabolism Telomere Telomere Shortening Thalassemia Young Adult
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