Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion

Sox9 is a transcription factor expressed in most solid tumors. However, the molecular mechanisms underlying Sox9 function during tumorigenesis remain unclear. Here, using a genetic mouse model of basal cell carcinoma (BCC), the most frequent cancer in humans, we show that Sox9 is expressed from the...

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Veröffentlicht in:	Cell stem cell 2015-07, Vol.17 (1), p.60-73
Hauptverfasser:	Larsimont, Jean-Christophe, Youssef, Khalil Kass, Sánchez-Danés, Adriana, Sukumaran, Vijayakumar, Defrance, Matthieu, Delatte, Benjamin, Liagre, Mélanie, Baatsen, Pieter, Marine, Jean-Christophe, Lippens, Saskia, Guerin, Christopher, Del Marmol, Véronique, Vanderwinden, Jean-Marie, Fuks, Francois, Blanpain, Cédric
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - physiology Animals Carcinogenesis Carcinoma, Basal Cell - etiology Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - physiopathology Cell Adhesion Cell Self Renewal - genetics Cell Self Renewal - physiology Cell Transformation, Neoplastic - genetics Extracellular Matrix - physiology Female Gene Deletion Hedgehog Proteins - physiology Humans Male Mice Mice, Knockout Mice, Transgenic Models, Biological Mutation Neoplasm Invasiveness Neoplastic Stem Cells - physiology Oncogenes Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Signal Transduction Skin Neoplasms - etiology Skin Neoplasms - genetics Skin Neoplasms - physiopathology Smoothened Receptor SOX9 Transcription Factor - genetics SOX9 Transcription Factor - physiology
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