Iron-Catalyzed Intramolecular C(sp 2)–N Cyclization of 1‑(N‑Arylpyrrol-2-yl)ethanone O‑Acetyl Oximes toward Pyrrolo[1,2‑a]quinoxaline Derivatives
An efficient and convenient iron-catalyzed protocol has been developed for the synthesis of substituted pyrrolo[1,2-a]quinoxalines from 1-(N-arylpyrrol-2-yl)ethanone O-acetyl oximes through N–O bond cleavage and intramolecular directed C–H arylation reactions in acetic acid.
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| Veröffentlicht in: | Journal of organic chemistry 2015-07, Vol.80 (13), p.6875-6884 |
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| container_end_page | 6884 |
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| container_issue | 13 |
| container_start_page | 6875 |
| container_title | Journal of organic chemistry |
| container_volume | 80 |
| creator | Zhang, Zhiguo Li, Junlong Zhang, Guisheng Ma, Nana Liu, Qingfeng Liu, Tongxin |
| description | An efficient and convenient iron-catalyzed protocol has been developed for the synthesis of substituted pyrrolo[1,2-a]quinoxalines from 1-(N-arylpyrrol-2-yl)ethanone O-acetyl oximes through N–O bond cleavage and intramolecular directed C–H arylation reactions in acetic acid. |
| doi_str_mv | 10.1021/acs.joc.5b00915 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-3263 |
| ispartof | Journal of organic chemistry, 2015-07, Vol.80 (13), p.6875-6884 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Catalysis Cyclization Iron - chemistry Molecular Structure Oximes - chemistry Pyrroles - chemical synthesis Pyrroles - chemistry Quinoxalines - chemistry |
| title | Iron-Catalyzed Intramolecular C(sp 2)–N Cyclization of 1‑(N‑Arylpyrrol-2-yl)ethanone O‑Acetyl Oximes toward Pyrrolo[1,2‑a]quinoxaline Derivatives |
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