Fibrosis — A Common Pathway to Organ Injury and Failure
To the Editor: In their review, Rockey et al. (March 19 issue) 1 do not include drugs as a possible trigger of lung and cardiac fibrosis. A well-recognized cause of pulmonary fibrosis is drugs — in particular, antineoplastic agents such as bleomycin, busulfan, cyclophosphamide, and carmustine. 2 Oth...
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| Veröffentlicht in: | The New England journal of medicine 2015-07, Vol.373 (1), p.95-96 |
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| container_title | The New England journal of medicine |
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| creator | Ben Salem, Chaker Slim, Raoudha Fathallah, Neila Urban, Maria L Manenti, Lucio Vaglio, Augusto Rockey, Don C Bell, P. Darwin Hill, Joseph A |
| description | To the Editor:
In their review, Rockey et al. (March 19 issue)
1
do not include drugs as a possible trigger of lung and cardiac fibrosis. A well-recognized cause of pulmonary fibrosis is drugs — in particular, antineoplastic agents such as bleomycin, busulfan, cyclophosphamide, and carmustine.
2
Other drugs, such as nitrofurantoin, amiodarone, procainamide, flecainide, and penicillamine, have also been implicated. The prognosis in patients with fibrosis induced by alkylating agents is often poor, and the mortality rate is high. The changes in the lung include fibrosis of the alveolar septa and enlargement of the type II alveolar-lining cells.
2
Drug-induced pulmonary fibrosis . . . |
| doi_str_mv | 10.1056/NEJMc1504848 |
| format | Article |
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In their review, Rockey et al. (March 19 issue)
1
do not include drugs as a possible trigger of lung and cardiac fibrosis. A well-recognized cause of pulmonary fibrosis is drugs — in particular, antineoplastic agents such as bleomycin, busulfan, cyclophosphamide, and carmustine.
2
Other drugs, such as nitrofurantoin, amiodarone, procainamide, flecainide, and penicillamine, have also been implicated. The prognosis in patients with fibrosis induced by alkylating agents is often poor, and the mortality rate is high. The changes in the lung include fibrosis of the alveolar septa and enlargement of the type II alveolar-lining cells.
2
Drug-induced pulmonary fibrosis . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc1504848</identifier><identifier>PMID: 26132959</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Alkylating agents ; Alveoli ; Amiodarone ; Antineoplastic drugs ; Bleomycin ; Busulfan ; Cardiovascular disease ; Cyclophosphamide ; Fibrosis ; Humans ; Lung diseases ; Multiple Organ Failure - etiology ; Nitrofurantoin ; Pulmonary fibrosis ; Septum</subject><ispartof>The New England journal of medicine, 2015-07, Vol.373 (1), p.95-96</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-191c224c0c5b75e89ac4b555fce2c828b7dc83beed0a49e69fde8bbad7c2e2743</citedby><cites>FETCH-LOGICAL-c605t-191c224c0c5b75e89ac4b555fce2c828b7dc83beed0a49e69fde8bbad7c2e2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc1504848$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMc1504848$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26132959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben Salem, Chaker</creatorcontrib><creatorcontrib>Slim, Raoudha</creatorcontrib><creatorcontrib>Fathallah, Neila</creatorcontrib><creatorcontrib>Urban, Maria L</creatorcontrib><creatorcontrib>Manenti, Lucio</creatorcontrib><creatorcontrib>Vaglio, Augusto</creatorcontrib><creatorcontrib>Rockey, Don C</creatorcontrib><creatorcontrib>Bell, P. Darwin</creatorcontrib><creatorcontrib>Hill, Joseph A</creatorcontrib><title>Fibrosis — A Common Pathway to Organ Injury and Failure</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
In their review, Rockey et al. (March 19 issue)
1
do not include drugs as a possible trigger of lung and cardiac fibrosis. A well-recognized cause of pulmonary fibrosis is drugs — in particular, antineoplastic agents such as bleomycin, busulfan, cyclophosphamide, and carmustine.
2
Other drugs, such as nitrofurantoin, amiodarone, procainamide, flecainide, and penicillamine, have also been implicated. The prognosis in patients with fibrosis induced by alkylating agents is often poor, and the mortality rate is high. The changes in the lung include fibrosis of the alveolar septa and enlargement of the type II alveolar-lining cells.
2
Drug-induced pulmonary fibrosis . . .</description><subject>Alkylating agents</subject><subject>Alveoli</subject><subject>Amiodarone</subject><subject>Antineoplastic drugs</subject><subject>Bleomycin</subject><subject>Busulfan</subject><subject>Cardiovascular disease</subject><subject>Cyclophosphamide</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Lung diseases</subject><subject>Multiple Organ Failure - etiology</subject><subject>Nitrofurantoin</subject><subject>Pulmonary fibrosis</subject><subject>Septum</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0btOwzAUBmALgWgpbMzIEgwMBHyPPVZVC0WFMsAcOY4DiXIpdiLUjYfgCXkSAi0IIYae5SyffumcH4BDjM4x4uLidnx9YzBHTDK5BfqYUxowhsQ26CNEZMBCRXtgz_scdYOZ2gU9IjAliqs-UJMsdrXPPHx_fYNDOKrLsq7gnW6eXvQSNjWcu0ddwWmVt24JdZXAic6K1tl9sJPqwtuD9R6Ah8n4fnQVzOaX09FwFhiBeBNghQ0hzCDD45BbqbRhMec8NZYYSWQcJkbS2NoEaaasUGliZRzrJDTEkpDRAThd5S5c_dxa30Rl5o0tCl3ZuvURFoqGpDsYbUipkHQzihVBuKPHf2het67qbv5SBAuCZKfOVsp07_TOptHCZaV2ywij6LOo6HdRHT9ah7ZxaZMf_N1MB05WoCx9VNm8_D_nA6awlmU</recordid><startdate>20150702</startdate><enddate>20150702</enddate><creator>Ben Salem, Chaker</creator><creator>Slim, Raoudha</creator><creator>Fathallah, Neila</creator><creator>Urban, Maria L</creator><creator>Manenti, Lucio</creator><creator>Vaglio, Augusto</creator><creator>Rockey, Don C</creator><creator>Bell, P. 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Darwin</au><au>Hill, Joseph A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrosis — A Common Pathway to Organ Injury and Failure</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-07-02</date><risdate>2015</risdate><volume>373</volume><issue>1</issue><spage>95</spage><epage>96</epage><pages>95-96</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
In their review, Rockey et al. (March 19 issue)
1
do not include drugs as a possible trigger of lung and cardiac fibrosis. A well-recognized cause of pulmonary fibrosis is drugs — in particular, antineoplastic agents such as bleomycin, busulfan, cyclophosphamide, and carmustine.
2
Other drugs, such as nitrofurantoin, amiodarone, procainamide, flecainide, and penicillamine, have also been implicated. The prognosis in patients with fibrosis induced by alkylating agents is often poor, and the mortality rate is high. The changes in the lung include fibrosis of the alveolar septa and enlargement of the type II alveolar-lining cells.
2
Drug-induced pulmonary fibrosis . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26132959</pmid><doi>10.1056/NEJMc1504848</doi><tpages>2</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 2015-07, Vol.373 (1), p.95-96 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Alkylating agents Alveoli Amiodarone Antineoplastic drugs Bleomycin Busulfan Cardiovascular disease Cyclophosphamide Fibrosis Humans Lung diseases Multiple Organ Failure - etiology Nitrofurantoin Pulmonary fibrosis Septum |
| title | Fibrosis — A Common Pathway to Organ Injury and Failure |
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