Causality and Chance in the Development of Cancer
In addition to heredity and the environment, chance may also play a role in the development of cancer. Because the acquisition of mutations is stochastic with each cell division, organs with more stem-cell replication seem to develop cancer more often. The notion that, in addition to heredity (HER)...
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| Veröffentlicht in: | The New England journal of medicine 2015-07, Vol.373 (1), p.84-88 |
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| creator | Luzzatto, Lucio Pandolfi, Pier Paolo |
| description | In addition to heredity and the environment, chance may also play a role in the development of cancer. Because the acquisition of mutations is stochastic with each cell division, organs with more stem-cell replication seem to develop cancer more often.
The notion that, in addition to heredity (HER) and the environment (ENV), chance (C) is also a factor in oncogenesis is not new.
1
,
2
However, it has received new impetus from the recent work by Tomasetti and Vogelstein,
3
who reported a strong correlation between the frequency of tumors of individual organs or tissue types and the estimated number of stem-cell divisions in those organs or tissues. Thus, the wide variation between common tumors (e.g., colorectal cancer, which will develop in nearly 1 in 20 persons) and very rare tumors (e.g., osteosarcoma, which will develop in fewer than 1 in 10,000 . . . |
| doi_str_mv | 10.1056/NEJMsb1502456 |
| format | Article |
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The notion that, in addition to heredity (HER) and the environment (ENV), chance (C) is also a factor in oncogenesis is not new.
1
,
2
However, it has received new impetus from the recent work by Tomasetti and Vogelstein,
3
who reported a strong correlation between the frequency of tumors of individual organs or tissue types and the estimated number of stem-cell divisions in those organs or tissues. Thus, the wide variation between common tumors (e.g., colorectal cancer, which will develop in nearly 1 in 20 persons) and very rare tumors (e.g., osteosarcoma, which will develop in fewer than 1 in 10,000 . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMsb1502456</identifier><identifier>PMID: 26132946</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Cancer ; Carcinogenesis - genetics ; Causality ; Cell division ; Cell Division - genetics ; Cell Transformation, Neoplastic - genetics ; Gene-Environment Interaction ; Humans ; Mutation ; Neoplasms - etiology ; Risk ; Rodents ; Stem cells ; Stem Cells - physiology ; Tumors</subject><ispartof>The New England journal of medicine, 2015-07, Vol.373 (1), p.84-88</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-21ae15a7351111e680d54c43356667553ce7905eb173857886f6ae3238af990f3</citedby><cites>FETCH-LOGICAL-c417t-21ae15a7351111e680d54c43356667553ce7905eb173857886f6ae3238af990f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMsb1502456$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1693216050?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,2745,2746,26082,27903,27904,52361,54043,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26132946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luzzatto, Lucio</creatorcontrib><creatorcontrib>Pandolfi, Pier Paolo</creatorcontrib><title>Causality and Chance in the Development of Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In addition to heredity and the environment, chance may also play a role in the development of cancer. Because the acquisition of mutations is stochastic with each cell division, organs with more stem-cell replication seem to develop cancer more often.
The notion that, in addition to heredity (HER) and the environment (ENV), chance (C) is also a factor in oncogenesis is not new.
1
,
2
However, it has received new impetus from the recent work by Tomasetti and Vogelstein,
3
who reported a strong correlation between the frequency of tumors of individual organs or tissue types and the estimated number of stem-cell divisions in those organs or tissues. Thus, the wide variation between common tumors (e.g., colorectal cancer, which will develop in nearly 1 in 20 persons) and very rare tumors (e.g., osteosarcoma, which will develop in fewer than 1 in 10,000 . . .</description><subject>Cancer</subject><subject>Carcinogenesis - genetics</subject><subject>Causality</subject><subject>Cell division</subject><subject>Cell Division - genetics</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Gene-Environment Interaction</subject><subject>Humans</subject><subject>Mutation</subject><subject>Neoplasms - etiology</subject><subject>Risk</subject><subject>Rodents</subject><subject>Stem cells</subject><subject>Stem Cells - physiology</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E1Lw0AQBuBFFFurR68SEMFLdCf7lT1KWr-oetFz2KYTmpJs6m4i9N-7tVVQcC5zmIeX4SXkFOgVUCGvnyePT34GgiZcyD0yBMFYzDmV-2RIaZLGXGk2IEfeL2kY4PqQDBIJLNFcDglkpvemrrp1ZOw8yhbGFhhVNuoWGI3xA-t21aDtoraMss3NHZOD0tQeT3Z7RN5uJ6_ZfTx9uXvIbqZxwUF1cQIGQRjFBIRBmdK54AVnTEgplRCsQKWpwBkolgqVprKUBlnCUlNqTUs2Ipfb3JVr33v0Xd5UvsC6Nhbb3ucgNVOgQehAz__QZds7G777UglIKmhQ8VYVrvXeYZmvXNUYt86B5psu819dBn-2S-1nDc5_9Hd5AVxsQdP43OKy-SfoE150dhk</recordid><startdate>20150702</startdate><enddate>20150702</enddate><creator>Luzzatto, Lucio</creator><creator>Pandolfi, Pier Paolo</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150702</creationdate><title>Causality and Chance in the Development of Cancer</title><author>Luzzatto, Lucio ; 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Because the acquisition of mutations is stochastic with each cell division, organs with more stem-cell replication seem to develop cancer more often.
The notion that, in addition to heredity (HER) and the environment (ENV), chance (C) is also a factor in oncogenesis is not new.
1
,
2
However, it has received new impetus from the recent work by Tomasetti and Vogelstein,
3
who reported a strong correlation between the frequency of tumors of individual organs or tissue types and the estimated number of stem-cell divisions in those organs or tissues. Thus, the wide variation between common tumors (e.g., colorectal cancer, which will develop in nearly 1 in 20 persons) and very rare tumors (e.g., osteosarcoma, which will develop in fewer than 1 in 10,000 . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26132946</pmid><doi>10.1056/NEJMsb1502456</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Cancer Carcinogenesis - genetics Causality Cell division Cell Division - genetics Cell Transformation, Neoplastic - genetics Gene-Environment Interaction Humans Mutation Neoplasms - etiology Risk Rodents Stem cells Stem Cells - physiology Tumors |
| title | Causality and Chance in the Development of Cancer |
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