Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions

Antibodies are now recognized as key therapeutic tools to combat most forms of malignancy. Although the first wave of therapeutic antibodies that emerged over two decades ago directly target tumor cells for killing, a new class of antibody therapies targeting immunoregulatory pathways to boost antit...

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Veröffentlicht in:	Cancer immunology research 2015-07, Vol.3 (7), p.704-713
Hauptverfasser:	DiLillo, David J, Ravetch, Jeffrey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antibodies, Neoplasm - therapeutic use Humans Immunization, Passive - methods Mice Neoplasms - drug therapy Receptors, IgG - immunology
Online-Zugang:	Volltext
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