Ensuring confidence in predictions: A scheme to assess the scientific validity of in silico models

The use of in silico tools within the drug development process to predict a wide range of properties including absorption, distribution, metabolism, elimination and toxicity has become increasingly important due to changes in legislation and both ethical and economic drivers to reduce animal testing...

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Veröffentlicht in:	Advanced drug delivery reviews 2015-06, Vol.86, p.101-111
Hauptverfasser:	Hewitt, Mark, Ellison, Claire M., Cronin, Mark T.D., Pastor, Manuel, Steger-Hartmann, Thomas, Munoz-Muriendas, Jordi, Pognan, Francois, Madden, Judith C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Good computer modelling practice Humans Model reliability Models, Theoretical Peer-verification Pilot Projects QSAR Reproducibility of Results Toxicity prediction Validation
Online-Zugang:	Volltext
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