Tiagabine inhibits haloperidol-induced oral dyskinesias in rats

Chronic administration of haloperidol to male Sprague Dawley rats for 6 months at a dosage of 1.5 mg/kg/day produces oral dyskinesias in a significant percent of the treated group. This has been used as an animal model of tardive dyskinesia in several laboratories, because the rat movements display...

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Veröffentlicht in:	Journal of Neural Transmission 1994-01, Vol.95 (1), p.63-69
Hauptverfasser:	GAO, X. M, KAKIGI, T, FRIEDMAN, M. B, TAMMINGA, C. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Models, Animal Drug Evaluation, Preclinical Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - prevention & control gamma-Aminobutyric Acid - physiology Haloperidol - antagonists & inhibitors Haloperidol - toxicity Male Mastication - drug effects Medical sciences Muscle Nipecotic Acids - pharmacology Nipecotic Acids - therapeutic use Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Single-Blind Method
Online-Zugang:	Volltext
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