N-Methyl- d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo
The effects of infusing N-methyl- d-aspartate (NMDA) and the specific NMDA receptor antagonist d-2-amino-5-phosphonopropionic acid ( d-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intrace...
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| Veröffentlicht in: | Neuroscience letters 1994-03, Vol.169 (1), p.215-218 |
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| creator | Whitton, P.S. Richards, D.A. Biggs, C.S. Fowler, L.J. |
| description | The effects of infusing
N-methyl-
d-aspartate (NMDA) and the specific NMDA receptor antagonist
d-2-amino-5-phosphonopropionic acid (
d-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1–100 μM) caused a concentration-dependent increase in 5-HT.
d-AP5 (10 μM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen.
d-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while
d-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 μM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 μM). In hippocampus, 1 μM TTX caused a slight but non-significant augmentation of the effect of 10 μM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists. |
| doi_str_mv | 10.1016/0304-3940(94)90395-6 |
| format | Article |
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N-methyl-
d-aspartate (NMDA) and the specific NMDA receptor antagonist
d-2-amino-5-phosphonopropionic acid (
d-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1–100 μM) caused a concentration-dependent increase in 5-HT.
d-AP5 (10 μM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen.
d-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while
d-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 μM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 μM). In hippocampus, 1 μM TTX caused a slight but non-significant augmentation of the effect of 10 μM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(94)90395-6</identifier><identifier>PMID: 7519338</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>2-Amino-5-phosphonovalerate - pharmacology ; 5-Hydroxyindoleacetic acid: Intracerebral dialysis ; Animals ; Behavior, Animal - drug effects ; Extracellular Space - drug effects ; Extracellular Space - metabolism ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hydroxyindoleacetic Acid - metabolism ; Male ; Microdialysis ; N-Methyl- d-aspartate ; N-Methylaspartate - pharmacology ; Neostriatum - drug effects ; Neostriatum - metabolism ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - drug effects ; Receptors, N-Methyl-D-Aspartate - physiology ; Serotonin ; Serotonin - metabolism ; Tetrodotoxin - pharmacology</subject><ispartof>Neuroscience letters, 1994-03, Vol.169 (1), p.215-218</ispartof><rights>1994 Elsevier Science Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-f731a38f4910a6524c8f9f6bd4208c244399e31b89279cdc51666d7292da42533</citedby><cites>FETCH-LOGICAL-c388t-f731a38f4910a6524c8f9f6bd4208c244399e31b89279cdc51666d7292da42533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394094903956$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7519338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitton, P.S.</creatorcontrib><creatorcontrib>Richards, D.A.</creatorcontrib><creatorcontrib>Biggs, C.S.</creatorcontrib><creatorcontrib>Fowler, L.J.</creatorcontrib><title>N-Methyl- d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The effects of infusing
N-methyl-
d-aspartate (NMDA) and the specific NMDA receptor antagonist
d-2-amino-5-phosphonopropionic acid (
d-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1–100 μM) caused a concentration-dependent increase in 5-HT.
d-AP5 (10 μM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen.
d-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while
d-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 μM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 μM). In hippocampus, 1 μM TTX caused a slight but non-significant augmentation of the effect of 10 μM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists.</description><subject>2-Amino-5-phosphonovalerate - pharmacology</subject><subject>5-Hydroxyindoleacetic acid: Intracerebral dialysis</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Extracellular Space - drug effects</subject><subject>Extracellular Space - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Male</subject><subject>Microdialysis</subject><subject>N-Methyl- d-aspartate</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Tetrodotoxin - pharmacology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1EVZbCPwDJJwQHF3_FiS9IqOJLassFzpbXnmiNkjjYzqq58dNx2FWPnObjfWdG8yD0itFrRpl6TwWVRGhJ32r5TlOhG6KeoB3rWk5a3fKnaPdoeYae5_yLUtqwRl6iy7ZhWohuh_7ckzsoh3Ug2BObZ5uKLYATOJhLTBmP0S_D1oKHkqyDYahlwg05rD7Fh7WkdS52DBNgFycHU3WVECccJlwzfAjzHJ0d5yVjO3mcSwq2LOOmH8MxvkAXvR0yvDzHK_Tz86cfN1_J7fcv324-3hInuq6QvhXMiq6XmlGrGi5d1-te7b3ktHNcSqE1CLbvNG-1865hSinfcs29lbwR4gq9Oe2dU_y9QC5mDHl7x04Ql2yY0lxLRqtRnowuxZwT9GZOYbRpNYyaDbzZqJqNqtHS_ANvVB17fd6_7Efwj0Nn0lX_cNKhPnkMkEx2ASowHyrsYnwM_z_wF9sNlFk</recordid><startdate>19940314</startdate><enddate>19940314</enddate><creator>Whitton, P.S.</creator><creator>Richards, D.A.</creator><creator>Biggs, C.S.</creator><creator>Fowler, L.J.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19940314</creationdate><title>N-Methyl- d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo</title><author>Whitton, P.S. ; Richards, D.A. ; Biggs, C.S. ; Fowler, L.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-f731a38f4910a6524c8f9f6bd4208c244399e31b89279cdc51666d7292da42533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>2-Amino-5-phosphonovalerate - pharmacology</topic><topic>5-Hydroxyindoleacetic acid: Intracerebral dialysis</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Extracellular Space - drug effects</topic><topic>Extracellular Space - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>Male</topic><topic>Microdialysis</topic><topic>N-Methyl- d-aspartate</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>Tetrodotoxin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitton, P.S.</creatorcontrib><creatorcontrib>Richards, D.A.</creatorcontrib><creatorcontrib>Biggs, C.S.</creatorcontrib><creatorcontrib>Fowler, L.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitton, P.S.</au><au>Richards, D.A.</au><au>Biggs, C.S.</au><au>Fowler, L.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Methyl- d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1994-03-14</date><risdate>1994</risdate><volume>169</volume><issue>1</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>The effects of infusing
N-methyl-
d-aspartate (NMDA) and the specific NMDA receptor antagonist
d-2-amino-5-phosphonopropionic acid (
d-AP5) into rat hippocampus and striatum on extracellular 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy-indoleacetic acid (5-HIAA) were studied using intracerebral microdialysis. In striatum, NMDA (1–100 μM) caused a concentration-dependent increase in 5-HT.
d-AP5 (10 μM) infusion caused increased extracellular 5-HT. When the two drugs were co-infused, no effect on extracellular 5-HT was seen.
d-AP5 alone was found to cause a delayed but sustained increase in dialysate 5-HIAA. In hippocampus, NMDA infusion caused a dose-dependent decrease in extracellular 5-HT while
d-AP5 produced a transitory increase in 5-HT level. NMDA caused a decrease in dialysate 5-HIAA. In striatum, the effect of 10 μM NMDA infusion was abolished by co-infusion with tetrodotoxin (TTX; 1 μM). In hippocampus, 1 μM TTX caused a slight but non-significant augmentation of the effect of 10 μM NMDA alone. These data indicate that NMDA receptors mediate control over 5-HT release and metabolism in different brain regions and may in part explain the behavioural effects of non-competitive NMDA receptor antagonists.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>7519338</pmid><doi>10.1016/0304-3940(94)90395-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1994-03, Vol.169 (1), p.215-218 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16929410 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 2-Amino-5-phosphonovalerate - pharmacology 5-Hydroxyindoleacetic acid: Intracerebral dialysis Animals Behavior, Animal - drug effects Extracellular Space - drug effects Extracellular Space - metabolism Hippocampus - drug effects Hippocampus - metabolism Hydroxyindoleacetic Acid - metabolism Male Microdialysis N-Methyl- d-aspartate N-Methylaspartate - pharmacology Neostriatum - drug effects Neostriatum - metabolism Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Serotonin Serotonin - metabolism Tetrodotoxin - pharmacology |
| title | N-Methyl- d-aspartate receptors modulate extracellular 5-hydroxytryptamine concentration in rat hippocampus and striatum in vivo |
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