Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack
EXPRESSION of viral genes in transgenic plants is a very effective tool for attenuating plant viral infection 1–3 . Nevertheless, the lack of generality and risk issues related to the expression of viral genes in plants 4 might limit the exploitation of this strategy. Expression in plants of antibod...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1993-12, Vol.366 (6454), p.469-472 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 472 |
|---|---|
| container_issue | 6454 |
| container_start_page | 469 |
| container_title | Nature (London) |
| container_volume | 366 |
| creator | Tavladoraki, Paraskevi Benvenuto, Eugenio Trinca, Stefania De Martinis, Domenico Cattaneo, Antonino Galeffi, Patrizia |
| description | EXPRESSION of viral genes in transgenic plants is a very effective tool for attenuating plant viral infection
1–3
. Nevertheless, the lack of generality and risk issues related to the expression of viral genes in plants
4
might limit the exploitation of this strategy. Expression in plants of antibodies against essential viral proteins could provide an alternative approach to engineer viral resistance. Recently, expression of complete
5–7
or engineered
7–9
antibodies has been successfully achieved in plants. The engineered single-chain Fv antbody scFv (refs 10,11) is particularly suitable for expression in plants because of its small size and the lack of assembly requirements. Here we present evidence that constitutive expression in transgenic plants of a scFv antibody, directed against the plant icosahedral tombusvirus artichoke mottled crinkle virus, causes reduction of infection incidence and delay in symptom development. |
| doi_str_mv | 10.1038/366469a0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16928151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4950372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-df812656401d7835ea7f650a77a7a3e3d3cc9d67cfaabf40528e9acfbaf88b6e3</originalsourceid><addsrcrecordid>eNplkV9r1UAQxRdR6rUKfgFhERF9iO6_7G4epbQqFPrSPofJZva6NTeJO0nxfvtuudcK-jQw58fMnDOMvZbikxTaf9bWGtuAeMI20jhbGevdU7YRQvlKeG2fsxdEt0KIWjpzwk68Mk7WdsOm6wwjbXFMgc8DjAtx_D1nJErjlgOP6xiWNI0w8IfOgFX4AWnkF3e8wKmb-j2HjJxmDCmmAMOw53OeFgwL9jzmacfvUl6Jw7JA-PmSPYswEL461lN2c3F-ffaturz6-v3sy2UVjK2Xqo9eKltbI2TvvK4RXLS1AOfAgUbd6xCa3roQAbpoRK08NhBiB9H7zqI-Ze8Pc8stv1akpd0lCjgUizit1ErbKC9rWcC3_4C305qLX2qVMMYoWasCfThAIU9EGWM757SDvG-laB8e0P55QEHfHOet3Q77R_CYeNHfHXWgklYs8YdEj5j2QrlGF-zjAaOijFvMf8_6b-U9C6Sb7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204442152</pqid></control><display><type>article</type><title>Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tavladoraki, Paraskevi ; Benvenuto, Eugenio ; Trinca, Stefania ; De Martinis, Domenico ; Cattaneo, Antonino ; Galeffi, Patrizia</creator><creatorcontrib>Tavladoraki, Paraskevi ; Benvenuto, Eugenio ; Trinca, Stefania ; De Martinis, Domenico ; Cattaneo, Antonino ; Galeffi, Patrizia</creatorcontrib><description>EXPRESSION of viral genes in transgenic plants is a very effective tool for attenuating plant viral infection
1–3
. Nevertheless, the lack of generality and risk issues related to the expression of viral genes in plants
4
might limit the exploitation of this strategy. Expression in plants of antibodies against essential viral proteins could provide an alternative approach to engineer viral resistance. Recently, expression of complete
5–7
or engineered
7–9
antibodies has been successfully achieved in plants. The engineered single-chain Fv antbody scFv (refs 10,11) is particularly suitable for expression in plants because of its small size and the lack of assembly requirements. Here we present evidence that constitutive expression in transgenic plants of a scFv antibody, directed against the plant icosahedral tombusvirus artichoke mottled crinkle virus, causes reduction of infection incidence and delay in symptom development.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/366469a0</identifier><identifier>PMID: 8247156</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Agronomy. Soil science and plant productions ; Antibodies, Viral - genetics ; Antibodies, Viral - immunology ; artichoke mottled crinkle virus ; Base Sequence ; Biological and medical sciences ; Biotechnology ; Capsid - immunology ; Cloning, Molecular ; Flowers & plants ; Fundamental and applied biological sciences. Psychology ; Genetic engineering applications ; Genetics and breeding of economic plants ; Humanities and Social Sciences ; Immunoglobulin Fragments - genetics ; Immunoglobulin Fragments - immunology ; Infections ; letter ; Molecular Sequence Data ; multidisciplinary ; Neutralization Tests ; Nicotiana - genetics ; Nicotiana - microbiology ; Phenotype ; Plant breeding: fundamental aspects and methodology ; Plant Diseases - microbiology ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - microbiology ; Plants, Toxic ; Science ; Science (multidisciplinary) ; tombusvirus ; Tombusvirus - genetics ; Tombusvirus - immunology ; Tombusvirus - physiology ; Transformation, Genetic ; Transgenic plants ; Viruses</subject><ispartof>Nature (London), 1993-12, Vol.366 (6454), p.469-472</ispartof><rights>Springer Nature Limited 1993</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Dec 2, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-df812656401d7835ea7f650a77a7a3e3d3cc9d67cfaabf40528e9acfbaf88b6e3</citedby><cites>FETCH-LOGICAL-c465t-df812656401d7835ea7f650a77a7a3e3d3cc9d67cfaabf40528e9acfbaf88b6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/366469a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/366469a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3802793$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8247156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tavladoraki, Paraskevi</creatorcontrib><creatorcontrib>Benvenuto, Eugenio</creatorcontrib><creatorcontrib>Trinca, Stefania</creatorcontrib><creatorcontrib>De Martinis, Domenico</creatorcontrib><creatorcontrib>Cattaneo, Antonino</creatorcontrib><creatorcontrib>Galeffi, Patrizia</creatorcontrib><title>Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>EXPRESSION of viral genes in transgenic plants is a very effective tool for attenuating plant viral infection
1–3
. Nevertheless, the lack of generality and risk issues related to the expression of viral genes in plants
4
might limit the exploitation of this strategy. Expression in plants of antibodies against essential viral proteins could provide an alternative approach to engineer viral resistance. Recently, expression of complete
5–7
or engineered
7–9
antibodies has been successfully achieved in plants. The engineered single-chain Fv antbody scFv (refs 10,11) is particularly suitable for expression in plants because of its small size and the lack of assembly requirements. Here we present evidence that constitutive expression in transgenic plants of a scFv antibody, directed against the plant icosahedral tombusvirus artichoke mottled crinkle virus, causes reduction of infection incidence and delay in symptom development.</description><subject>Agronomy. Soil science and plant productions</subject><subject>Antibodies, Viral - genetics</subject><subject>Antibodies, Viral - immunology</subject><subject>artichoke mottled crinkle virus</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Capsid - immunology</subject><subject>Cloning, Molecular</subject><subject>Flowers & plants</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic engineering applications</subject><subject>Genetics and breeding of economic plants</subject><subject>Humanities and Social Sciences</subject><subject>Immunoglobulin Fragments - genetics</subject><subject>Immunoglobulin Fragments - immunology</subject><subject>Infections</subject><subject>letter</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Neutralization Tests</subject><subject>Nicotiana - genetics</subject><subject>Nicotiana - microbiology</subject><subject>Phenotype</subject><subject>Plant breeding: fundamental aspects and methodology</subject><subject>Plant Diseases - microbiology</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - microbiology</subject><subject>Plants, Toxic</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>tombusvirus</subject><subject>Tombusvirus - genetics</subject><subject>Tombusvirus - immunology</subject><subject>Tombusvirus - physiology</subject><subject>Transformation, Genetic</subject><subject>Transgenic plants</subject><subject>Viruses</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkV9r1UAQxRdR6rUKfgFhERF9iO6_7G4epbQqFPrSPofJZva6NTeJO0nxfvtuudcK-jQw58fMnDOMvZbikxTaf9bWGtuAeMI20jhbGevdU7YRQvlKeG2fsxdEt0KIWjpzwk68Mk7WdsOm6wwjbXFMgc8DjAtx_D1nJErjlgOP6xiWNI0w8IfOgFX4AWnkF3e8wKmb-j2HjJxmDCmmAMOw53OeFgwL9jzmacfvUl6Jw7JA-PmSPYswEL461lN2c3F-ffaturz6-v3sy2UVjK2Xqo9eKltbI2TvvK4RXLS1AOfAgUbd6xCa3roQAbpoRK08NhBiB9H7zqI-Ze8Pc8stv1akpd0lCjgUizit1ErbKC9rWcC3_4C305qLX2qVMMYoWasCfThAIU9EGWM757SDvG-laB8e0P55QEHfHOet3Q77R_CYeNHfHXWgklYs8YdEj5j2QrlGF-zjAaOijFvMf8_6b-U9C6Sb7w</recordid><startdate>19931202</startdate><enddate>19931202</enddate><creator>Tavladoraki, Paraskevi</creator><creator>Benvenuto, Eugenio</creator><creator>Trinca, Stefania</creator><creator>De Martinis, Domenico</creator><creator>Cattaneo, Antonino</creator><creator>Galeffi, Patrizia</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7T7</scope></search><sort><creationdate>19931202</creationdate><title>Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack</title><author>Tavladoraki, Paraskevi ; Benvenuto, Eugenio ; Trinca, Stefania ; De Martinis, Domenico ; Cattaneo, Antonino ; Galeffi, Patrizia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-df812656401d7835ea7f650a77a7a3e3d3cc9d67cfaabf40528e9acfbaf88b6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Agronomy. Soil science and plant productions</topic><topic>Antibodies, Viral - genetics</topic><topic>Antibodies, Viral - immunology</topic><topic>artichoke mottled crinkle virus</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Capsid - immunology</topic><topic>Cloning, Molecular</topic><topic>Flowers & plants</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic engineering applications</topic><topic>Genetics and breeding of economic plants</topic><topic>Humanities and Social Sciences</topic><topic>Immunoglobulin Fragments - genetics</topic><topic>Immunoglobulin Fragments - immunology</topic><topic>Infections</topic><topic>letter</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Neutralization Tests</topic><topic>Nicotiana - genetics</topic><topic>Nicotiana - microbiology</topic><topic>Phenotype</topic><topic>Plant breeding: fundamental aspects and methodology</topic><topic>Plant Diseases - microbiology</topic><topic>Plants, Genetically Modified - genetics</topic><topic>Plants, Genetically Modified - microbiology</topic><topic>Plants, Toxic</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>tombusvirus</topic><topic>Tombusvirus - genetics</topic><topic>Tombusvirus - immunology</topic><topic>Tombusvirus - physiology</topic><topic>Transformation, Genetic</topic><topic>Transgenic plants</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavladoraki, Paraskevi</creatorcontrib><creatorcontrib>Benvenuto, Eugenio</creatorcontrib><creatorcontrib>Trinca, Stefania</creatorcontrib><creatorcontrib>De Martinis, Domenico</creatorcontrib><creatorcontrib>Cattaneo, Antonino</creatorcontrib><creatorcontrib>Galeffi, Patrizia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavladoraki, Paraskevi</au><au>Benvenuto, Eugenio</au><au>Trinca, Stefania</au><au>De Martinis, Domenico</au><au>Cattaneo, Antonino</au><au>Galeffi, Patrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1993-12-02</date><risdate>1993</risdate><volume>366</volume><issue>6454</issue><spage>469</spage><epage>472</epage><pages>469-472</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>EXPRESSION of viral genes in transgenic plants is a very effective tool for attenuating plant viral infection
1–3
. Nevertheless, the lack of generality and risk issues related to the expression of viral genes in plants
4
might limit the exploitation of this strategy. Expression in plants of antibodies against essential viral proteins could provide an alternative approach to engineer viral resistance. Recently, expression of complete
5–7
or engineered
7–9
antibodies has been successfully achieved in plants. The engineered single-chain Fv antbody scFv (refs 10,11) is particularly suitable for expression in plants because of its small size and the lack of assembly requirements. Here we present evidence that constitutive expression in transgenic plants of a scFv antibody, directed against the plant icosahedral tombusvirus artichoke mottled crinkle virus, causes reduction of infection incidence and delay in symptom development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8247156</pmid><doi>10.1038/366469a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1993-12, Vol.366 (6454), p.469-472 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16928151 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Agronomy. Soil science and plant productions Antibodies, Viral - genetics Antibodies, Viral - immunology artichoke mottled crinkle virus Base Sequence Biological and medical sciences Biotechnology Capsid - immunology Cloning, Molecular Flowers & plants Fundamental and applied biological sciences. Psychology Genetic engineering applications Genetics and breeding of economic plants Humanities and Social Sciences Immunoglobulin Fragments - genetics Immunoglobulin Fragments - immunology Infections letter Molecular Sequence Data multidisciplinary Neutralization Tests Nicotiana - genetics Nicotiana - microbiology Phenotype Plant breeding: fundamental aspects and methodology Plant Diseases - microbiology Plants, Genetically Modified - genetics Plants, Genetically Modified - microbiology Plants, Toxic Science Science (multidisciplinary) tombusvirus Tombusvirus - genetics Tombusvirus - immunology Tombusvirus - physiology Transformation, Genetic Transgenic plants Viruses |
| title | Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T01%3A23%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transgenic%20plants%20expressing%20a%20functional%20single-chain%20Fv%20antibody%20are%20specifically%20protected%20from%20virus%20attack&rft.jtitle=Nature%20(London)&rft.au=Tavladoraki,%20Paraskevi&rft.date=1993-12-02&rft.volume=366&rft.issue=6454&rft.spage=469&rft.epage=472&rft.pages=469-472&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/366469a0&rft_dat=%3Cproquest_cross%3E4950372%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204442152&rft_id=info:pmid/8247156&rfr_iscdi=true |