Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

Focal adhesions (FAs) link the extracellular matrix to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signalling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within FAs regulates their activity and function. Vinculin bin...

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Veröffentlicht in:	Nature cell biology 2015-07, Vol.17 (7), p.880-892
Hauptverfasser:	Case, Lindsay B., Baird, Michelle A., Shtengel, Gleb, Campbell, Sharon L., Hess, Harald F., Davidson, Michael W., Waterman, Clare M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 14/33 14/35 14/63 631/80/79 631/80/79/1236 631/80/79/2027 Actins - chemistry Actins - metabolism Biosensors Blotting, Western Cancer Research Cell adhesion Cell Biology Cell Line Cell Line, Tumor Cellular signal transduction Cytoskeletal proteins Developmental Biology Fluorescence Resonance Energy Transfer Focal Adhesions - genetics Focal Adhesions - metabolism Genetic aspects Humans Integrins - chemistry Integrins - metabolism Life Sciences Luminescent Proteins - genetics Luminescent Proteins - metabolism Microscopy, Fluorescence - methods Models, Molecular Mutation Nanostructures Nanotechnology - methods Paxillin - chemistry Paxillin - genetics Paxillin - metabolism Photoactivation Properties Protein Binding Protein Structure, Tertiary RNA Interference Stem Cells Talin - chemistry Talin - genetics Talin - metabolism Vinculin - chemistry Vinculin - genetics Vinculin - metabolism
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