Regional differences in perivascular adipose tissue impacting vascular homeostasis

Regional differences in perivascular adipose tissue impacting vascular homeostasis

Highlights • Non-uniform and separate PVAT depots are found in different organs and tissues. • Heterogeneous PVATs exhibit regional differences in phenotype and paracrine effects. • PVATs confer regional susceptibility to vascular complications. • PVATs may represent a novel target for pharmacologic...

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Veröffentlicht in:Trends in endocrinology and metabolism 2015-07, Vol.26 (7), p.367-375
Hauptverfasser: Gil-Ortega, Marta, Somoza, Beatriz, Huang, Yu, Gollasch, Maik, Fernández-Alfonso, Maria S
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes - cytology
Adipocytes - metabolism
Adipose Tissue - metabolism
Animals
Cell Differentiation - physiology
Endocrinology & Metabolism
Homeostasis
Humans
Hypertension - metabolism
Renin-Angiotensin System
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Beschreibung
Zusammenfassung:Highlights • Non-uniform and separate PVAT depots are found in different organs and tissues. • Heterogeneous PVATs exhibit regional differences in phenotype and paracrine effects. • PVATs confer regional susceptibility to vascular complications. • PVATs may represent a novel target for pharmacological intervention in cardiometabolic disorders.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2015.04.003