Extension of the Calvert formula to patients with severe renal insufficiency

Purpose The Calvert formula was derived from the study among patients with glomerular filtration rates (GFRs) of 33–135 ml/min, and it remains unclear whether the formula can be used to calculate optimal and safe dosages of carboplatin in patients with severe renal insufficiency. We evaluated the ut...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2015-07, Vol.76 (1), p.53-59
Hauptverfasser:	Oguri, Tomoyo, Shimokata, Tomoya, Ito, Isao, Yasuda, Yoshinari, Sassa, Naoto, Nishiyama, Masami, Hamada, Akinobu, Hasegawa, Yoshinori, Ando, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Cancer Research Carboplatin - administration & dosage Carboplatin - adverse effects Carboplatin - pharmacokinetics Female Glomerular Filtration Rate Humans Male Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Neoplasms - metabolism Oncology Original Article Pharmacology/Toxicology Prospective Studies Renal Insufficiency - metabolism
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