Spatially-Resolved Exploration of the Mouse Brain Glycome by Tissue Glyco-Capture (TGC) and Nano-LC/MS

Tissue glyco-capture (TGC), a highly sensitive MS-compatible method for extraction of glycans from tissue, was combined with structure-specific nano-LC/MS for sensitive and detailed profiling of the mouse brain glycome. Hundreds of glycan structures were directly detected by accurate mass MS and str...

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Veröffentlicht in:	Analytical chemistry (Washington) 2015-03, Vol.87 (5), p.2869-2877
Hauptverfasser:	Ji, In Jung, Hua, Serenus, Shin, Dong Hee, Seo, Nari, Hwang, Jae Yun, Jang, Ik-Soon, Kang, Myoung-Goo, Choi, Jong-Soon, An, Hyun Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Antennas Biochemistry Brain Brain - metabolism Cell adhesion & migration Chromatography, Liquid - methods Exploration Glycan Glycomics - methods Glycosylation Hippocampus Male Mass spectrometry Mice Mice, Inbred C57BL Nanostructure Nanotechnology - methods Polysaccharides - chemistry Reproducibility Rodents Signal transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tandem Mass Spectrometry - methods Tissues
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