Correlation of Solubilities of Hydrophilic Pharmaceuticals versus Dielectric Constants of Binary Solvents
In this paper, the polarity of binary solvents was studied by the sum law of cube roots of the dielectric constant. During the antisolvent crystallization process, the composition of the binary solvents and their dielectric constants changed simultaneously. These results demonstrated that variation...
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| Veröffentlicht in: | Industrial & engineering chemistry research 2012-05, Vol.51 (19), p.6933-6938 |
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| container_issue | 19 |
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| container_title | Industrial & engineering chemistry research |
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| creator | Zhang, Xinwei Yin, Qiuxiang Cui, Penglei Liu, Zengkun Gong, Junbo |
| description | In this paper, the polarity of binary solvents was studied by the sum law of cube roots of the dielectric constant. During the antisolvent crystallization process, the composition of the binary solvents and their dielectric constants changed simultaneously. These results demonstrated that variation of the solubility is dependent on the polarity of the binary solvents. On the basis of experiments, a new model was put forward to quantitatively describe the relationship between the solubility of hydrophilic pharmaceuticals and the dielectric constants of the binary solvents. Furthermore, this model was tested and verified by solubility data of other pharmaceuticals published in the literature with high accuracy. |
| doi_str_mv | 10.1021/ie202624d |
| format | Article |
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Eng. Chem. Res</addtitle><date>2012-05-16</date><risdate>2012</risdate><volume>51</volume><issue>19</issue><spage>6933</spage><epage>6938</epage><pages>6933-6938</pages><issn>0888-5885</issn><eissn>1520-5045</eissn><coden>IECRED</coden><abstract>In this paper, the polarity of binary solvents was studied by the sum law of cube roots of the dielectric constant. During the antisolvent crystallization process, the composition of the binary solvents and their dielectric constants changed simultaneously. These results demonstrated that variation of the solubility is dependent on the polarity of the binary solvents. On the basis of experiments, a new model was put forward to quantitatively describe the relationship between the solubility of hydrophilic pharmaceuticals and the dielectric constants of the binary solvents. 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| language | eng |
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| source | ACS Publications |
| subjects | Applied sciences Chemical engineering Crystallization Dielectric constant Exact sciences and technology Industrial engineering Mathematical models Pharmaceuticals Polarity Solubility Solvents |
| title | Correlation of Solubilities of Hydrophilic Pharmaceuticals versus Dielectric Constants of Binary Solvents |
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