Label-Free Measurement of Amyloid Elongation by Suspended Microchannel Resonators

Protein aggregation is a widely studied phenomenon that is associated with many human diseases and with the degradation of biotechnological products. Here, we establish a new label-free method for characterizing the aggregation kinetics of proteins into amyloid fibrils by suspended microchannel reso...

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Veröffentlicht in:	Analytical chemistry (Washington) 2015-02, Vol.87 (3), p.1821-1828
Hauptverfasser:	Wang, Yu, Modena, Mario Matteo, Platen, Mitja, Schaap, Iwan Alexander Taco, Burg, Thomas Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Amyloid - chemistry Binding sites Biochemistry Biotechnology Elongation Equipment Design Humans Immobilized Proteins - chemistry Inhibitors Insulin - chemistry Mathematical models Microchannels Microfluidic Analytical Techniques - instrumentation Molecules Monomers Protein Aggregates Proteins Resonators Transmission electron microscopy
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