Selective Green Synthesis of 1,5-Benzodiazepine over Modified Heteropolyacid as Nanocatalyst: Kinetics and Mechanism

The present work deals with synthesis of 2,3-dihydro-1H-1,5-benzodiazepine from o-phenylenediamine and acetophenone at 100 °C using a variety of solid acid catalysts, among which 20% w/w Cs2.5H0.5PW12O40 (Cs-DTP)/K-10 clay was the best. The effects of various parameters such as speed of agitation, c...

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Veröffentlicht in:	Industrial & engineering chemistry research 2013-12, Vol.52 (50), p.17812-17820
Hauptverfasser:	Yadav, Ganapati D, Yadav, Akhilesh R
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Sprache:	eng
Schlagworte:	Acetophenone Catalysis Catalysts Derivatives Industrial engineering Nanostructure Reaction kinetics Synthesis
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creator	Yadav, Ganapati D Yadav, Akhilesh R
description	The present work deals with synthesis of 2,3-dihydro-1H-1,5-benzodiazepine from o-phenylenediamine and acetophenone at 100 °C using a variety of solid acid catalysts, among which 20% w/w Cs2.5H0.5PW12O40 (Cs-DTP)/K-10 clay was the best. The effects of various parameters such as speed of agitation, catalyst loading, mole ratio of 1,2-diamine to acetophenone, and temperature were studied with 20%w/w Cs-DTP/K-10 to establish kinetics of the reaction. The catalyst was found highly active, robust and reusable. The reaction follows Langmuir–Hinshelwood–Hougen–Watson type of mechanism with weak adsorption of all species. The apparent energy of activation is 9.39 kcal/mol. The studies were extended to synthesis of various derivatives of benzodiazepines, which are biologically active.
doi_str_mv	10.1021/ie402654u
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The effects of various parameters such as speed of agitation, catalyst loading, mole ratio of 1,2-diamine to acetophenone, and temperature were studied with 20%w/w Cs-DTP/K-10 to establish kinetics of the reaction. The catalyst was found highly active, robust and reusable. The reaction follows Langmuir–Hinshelwood–Hougen–Watson type of mechanism with weak adsorption of all species. The apparent energy of activation is 9.39 kcal/mol. 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Eng. Chem. Res</addtitle><description>The present work deals with synthesis of 2,3-dihydro-1H-1,5-benzodiazepine from o-phenylenediamine and acetophenone at 100 °C using a variety of solid acid catalysts, among which 20% w/w Cs2.5H0.5PW12O40 (Cs-DTP)/K-10 clay was the best. The effects of various parameters such as speed of agitation, catalyst loading, mole ratio of 1,2-diamine to acetophenone, and temperature were studied with 20%w/w Cs-DTP/K-10 to establish kinetics of the reaction. The catalyst was found highly active, robust and reusable. The reaction follows Langmuir–Hinshelwood–Hougen–Watson type of mechanism with weak adsorption of all species. The apparent energy of activation is 9.39 kcal/mol. 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subjects	Acetophenone Catalysis Catalysts Derivatives Industrial engineering Nanostructure Reaction kinetics Synthesis
title	Selective Green Synthesis of 1,5-Benzodiazepine over Modified Heteropolyacid as Nanocatalyst: Kinetics and Mechanism
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