Encapsulation of a Low Aqueous Solubility Substance in a Biodegradable Polymer using Supercritical Fluid Extraction of Emulsion
The use of the supercritical fluid extraction of emulsion (SFEE) process for the polymer encapsulation of a low aqueous solubility drug substance was investigated, with focus placed on the carbon dioxide extraction step. The effects of process parameterscopolymer ratio, extraction time, pressure, a...
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| Veröffentlicht in: | Industrial & engineering chemistry research 2013-01, Vol.52 (1), p.134-141 |
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| container_title | Industrial & engineering chemistry research |
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| creator | Lin, Candy S Xu, Jane J Ng, Ka M Wibowo, Christianto Luo, Kathy Q |
| description | The use of the supercritical fluid extraction of emulsion (SFEE) process for the polymer encapsulation of a low aqueous solubility drug substance was investigated, with focus placed on the carbon dioxide extraction step. The effects of process parameterscopolymer ratio, extraction time, pressure, and temperatureon the drug content, encapsulation efficiency, and drug release profile of the polymer–drug composite particle were studied. Ibuprofen and polylactic-glycolic acid were chosen as the model system. Encapsulated particles of 100–300 nm were successfully obtained after freeze-drying. XRD and SEM analyses confirmed the entrapment of ibuprofen in an amorphous polymer matrix and the absence of ibuprofen external to the encapsulated particles. In addition to the solubility of ibuprofen, the particle surface area and, to a small extent, the glass transition temperature were found to influence the drug content and drug release profiles. These understandings are expected to facilitate the rational design of the extraction step of the SFEE process, especially for drugs that are relatively soluble in supercritical carbon dioxide. |
| doi_str_mv | 10.1021/ie300612r |
| format | Article |
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The effects of process parameterscopolymer ratio, extraction time, pressure, and temperatureon the drug content, encapsulation efficiency, and drug release profile of the polymer–drug composite particle were studied. Ibuprofen and polylactic-glycolic acid were chosen as the model system. Encapsulated particles of 100–300 nm were successfully obtained after freeze-drying. XRD and SEM analyses confirmed the entrapment of ibuprofen in an amorphous polymer matrix and the absence of ibuprofen external to the encapsulated particles. In addition to the solubility of ibuprofen, the particle surface area and, to a small extent, the glass transition temperature were found to influence the drug content and drug release profiles. These understandings are expected to facilitate the rational design of the extraction step of the SFEE process, especially for drugs that are relatively soluble in supercritical carbon dioxide.</description><identifier>ISSN: 0888-5885</identifier><identifier>EISSN: 1520-5045</identifier><identifier>DOI: 10.1021/ie300612r</identifier><language>eng</language><publisher>American Chemical Society</publisher><subject>Drug delivery systems ; Drugs ; Encapsulation ; Extraction ; Ibuprofen ; Particulate composites ; Solubility ; Supercritical fluids</subject><ispartof>Industrial & engineering chemistry research, 2013-01, Vol.52 (1), p.134-141</ispartof><rights>Copyright © 2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a325t-2f6fe8b95fb2043fdf7f6f391195df9239b0ecaabeff876157c7ec12a79b37493</citedby><cites>FETCH-LOGICAL-a325t-2f6fe8b95fb2043fdf7f6f391195df9239b0ecaabeff876157c7ec12a79b37493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ie300612r$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ie300612r$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids></links><search><creatorcontrib>Lin, Candy S</creatorcontrib><creatorcontrib>Xu, Jane J</creatorcontrib><creatorcontrib>Ng, Ka M</creatorcontrib><creatorcontrib>Wibowo, Christianto</creatorcontrib><creatorcontrib>Luo, Kathy Q</creatorcontrib><title>Encapsulation of a Low Aqueous Solubility Substance in a Biodegradable Polymer using Supercritical Fluid Extraction of Emulsion</title><title>Industrial & engineering chemistry research</title><addtitle>Ind. Eng. Chem. Res</addtitle><description>The use of the supercritical fluid extraction of emulsion (SFEE) process for the polymer encapsulation of a low aqueous solubility drug substance was investigated, with focus placed on the carbon dioxide extraction step. The effects of process parameterscopolymer ratio, extraction time, pressure, and temperatureon the drug content, encapsulation efficiency, and drug release profile of the polymer–drug composite particle were studied. Ibuprofen and polylactic-glycolic acid were chosen as the model system. Encapsulated particles of 100–300 nm were successfully obtained after freeze-drying. XRD and SEM analyses confirmed the entrapment of ibuprofen in an amorphous polymer matrix and the absence of ibuprofen external to the encapsulated particles. In addition to the solubility of ibuprofen, the particle surface area and, to a small extent, the glass transition temperature were found to influence the drug content and drug release profiles. These understandings are expected to facilitate the rational design of the extraction step of the SFEE process, especially for drugs that are relatively soluble in supercritical carbon dioxide.</description><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Encapsulation</subject><subject>Extraction</subject><subject>Ibuprofen</subject><subject>Particulate composites</subject><subject>Solubility</subject><subject>Supercritical fluids</subject><issn>0888-5885</issn><issn>1520-5045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqF0UFLwzAUB_AgCs7pwW-Qi6CHapI2bXOco1NhoDA9lzRNRkba1KRBd_Krmzn1JHjKI_zee_x5AJxjdI0RwTdapgjlmLgDMMGUoISijB6CCSrLMqFlSY_BifcbhBClWTYBH1Uv-OCD4aO2PbQKcri0b3D2GqQNHq6sCY02etzCVWj8yHshoe6jutW2lWvHW94YCZ-s2XbSweB1v450kE44PWrBDVyYoFtYvY-Oi58tVReMj_UpOFLceHn2_U7By6J6nt8ny8e7h_lsmfCU0DEhKleybBhVDUFZqlpVxJ-UYcxoqxhJWYOk4LyRSpVFjmkhCikw4QVr0iJj6RRc7ucOzsZofqw77YU0hve7nDXO45DYx_D_lGYpY3n5Ra_2VDjrvZOqHpzuuNvWGNW7e9S_94j2Ym-58PXGBtfHvH-4T45Fi3E</recordid><startdate>20130109</startdate><enddate>20130109</enddate><creator>Lin, Candy S</creator><creator>Xu, Jane J</creator><creator>Ng, Ka M</creator><creator>Wibowo, Christianto</creator><creator>Luo, Kathy Q</creator><general>American Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>8BQ</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>20130109</creationdate><title>Encapsulation of a Low Aqueous Solubility Substance in a Biodegradable Polymer using Supercritical Fluid Extraction of Emulsion</title><author>Lin, Candy S ; Xu, Jane J ; Ng, Ka M ; Wibowo, Christianto ; Luo, Kathy Q</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a325t-2f6fe8b95fb2043fdf7f6f391195df9239b0ecaabeff876157c7ec12a79b37493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Encapsulation</topic><topic>Extraction</topic><topic>Ibuprofen</topic><topic>Particulate composites</topic><topic>Solubility</topic><topic>Supercritical fluids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Candy S</creatorcontrib><creatorcontrib>Xu, Jane J</creatorcontrib><creatorcontrib>Ng, Ka M</creatorcontrib><creatorcontrib>Wibowo, Christianto</creatorcontrib><creatorcontrib>Luo, Kathy Q</creatorcontrib><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Industrial & engineering chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Candy S</au><au>Xu, Jane J</au><au>Ng, Ka M</au><au>Wibowo, Christianto</au><au>Luo, Kathy Q</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encapsulation of a Low Aqueous Solubility Substance in a Biodegradable Polymer using Supercritical Fluid Extraction of Emulsion</atitle><jtitle>Industrial & engineering chemistry research</jtitle><addtitle>Ind. Eng. Chem. Res</addtitle><date>2013-01-09</date><risdate>2013</risdate><volume>52</volume><issue>1</issue><spage>134</spage><epage>141</epage><pages>134-141</pages><issn>0888-5885</issn><eissn>1520-5045</eissn><abstract>The use of the supercritical fluid extraction of emulsion (SFEE) process for the polymer encapsulation of a low aqueous solubility drug substance was investigated, with focus placed on the carbon dioxide extraction step. The effects of process parameterscopolymer ratio, extraction time, pressure, and temperatureon the drug content, encapsulation efficiency, and drug release profile of the polymer–drug composite particle were studied. Ibuprofen and polylactic-glycolic acid were chosen as the model system. Encapsulated particles of 100–300 nm were successfully obtained after freeze-drying. XRD and SEM analyses confirmed the entrapment of ibuprofen in an amorphous polymer matrix and the absence of ibuprofen external to the encapsulated particles. In addition to the solubility of ibuprofen, the particle surface area and, to a small extent, the glass transition temperature were found to influence the drug content and drug release profiles. These understandings are expected to facilitate the rational design of the extraction step of the SFEE process, especially for drugs that are relatively soluble in supercritical carbon dioxide.</abstract><pub>American Chemical Society</pub><doi>10.1021/ie300612r</doi><tpages>8</tpages></addata></record> |
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| ispartof | Industrial & engineering chemistry research, 2013-01, Vol.52 (1), p.134-141 |
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| language | eng |
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| source | American Chemical Society Journals |
| subjects | Drug delivery systems Drugs Encapsulation Extraction Ibuprofen Particulate composites Solubility Supercritical fluids |
| title | Encapsulation of a Low Aqueous Solubility Substance in a Biodegradable Polymer using Supercritical Fluid Extraction of Emulsion |
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