Microspectroscopy (μFTIR) Reveals Co-localization of Lipid Oxidation and Amyloid Plaques in Human Alzheimer Disease Brains

Amyloid peptides are the main component of one of the characteristic pathological hallmarks of Alzheimer’s disease (AD): senile plaques. According to the amyloid cascade hypothesis, amyloid peptides may play a central role in the sequence of events that leads to neurodegeneration. However, there are...

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Veröffentlicht in:	Analytical chemistry (Washington) 2014-12, Vol.86 (24), p.12047-12054
Hauptverfasser:	Benseny-Cases, Núria, Klementieva, Oxana, Cotte, Marine, Ferrer, Isidre, Cladera, Josep
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Bands Brain Brain Chemistry Humans Immunohistochemistry - instrumentation Immunohistochemistry - methods Infrared Lipids Lipids - chemistry Microscopy Neurodegeneration Neuropathology Oxidation Oxidation-Reduction Oxidative stress Patients Peptides Plaque, Amyloid - chemistry Spectroscopy, Fourier Transform Infrared Spectrum analysis
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