The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension

Polymeric nanoparticles are designed to transport and deliver nitric oxide (NO) into hepatic stellate cells (HSCs) for the potential treatment of both liver fibrosis and portal hypertension. The nanoparticles, incorporating NO donor molecules (S‐nitrosoglutathione compound), are designed for liver d...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-05, Vol.11 (19), p.2291-2304
Hauptverfasser:	Duong, Hien T. T., Dong, Zhixia, Su, Lin, Boyer, Cyrille, George, Jacob, Davis, Thomas P., Wang, Jianhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Biomedical materials Blood Pressure - drug effects Cell Line Cell Survival - drug effects Collagen - metabolism drug delivery Endocytosis - drug effects Fibrosis Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Humans Hypertension Hypertension, Portal - drug therapy Hypertension, Portal - physiopathology Injections, Intravenous Liver Liver cirrhosis Liver Cirrhosis - drug therapy Liver Cirrhosis - physiopathology Male medicine Microscopy, Fluorescence Nanoparticles Nanoparticles - chemistry Nanotechnology Nitric oxide Nitric Oxide - pharmacology Nitric Oxide - therapeutic use Phenotype polymers Polymers - chemical synthesis Polymers - chemistry Rats, Sprague-Dawley Rodents S-Nitrosoglutathione - pharmacology Spectroscopy, Near-Infrared Surgical implants Tissue Distribution - drug effects Vitamin A Vitamin A - administration & dosage Vitamin A - pharmacology Vitamin A - therapeutic use Vitamins
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