Fine Control Over the Size of Surfactant–Polyelectrolyte Nanoparticles by Hydrodynamic Flow Focusing
Synthesis of surfactant–polyelectrolyte nanoparticles was carried out in a microfluidic device with a fine control over the size and the polydispersity. An anionic polysaccharide (sodium carboxymethylcellulose, CMC) solution was focused using a cationic surfactant (dodecyl trimethylammonium bromide,...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2013-06, Vol.85 (12), p.5850-5856 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Tresset, Guillaume Marculescu, Catalin Salonen, Anniina Ni, Ming Iliescu, Ciprian |
| description | Synthesis of surfactant–polyelectrolyte nanoparticles was carried out in a microfluidic device with a fine control over the size and the polydispersity. An anionic polysaccharide (sodium carboxymethylcellulose, CMC) solution was focused using a cationic surfactant (dodecyl trimethylammonium bromide, DTAB) solution in a microfluidic channel at selected ratios of flow rates and reagent concentrations. The methodology ensured a controlled mixing kinetics and a uniform distribution of charges at the mixing interface. The resulting nanoparticles exhibited remarkably well-defined and repeatable size distributions, with hydrodynamic diameters tunable from 50 up to 300 nm and polydispersity index around 0.1 in most cases. Microfluidic-assisted self-assembly may be an efficient way to produce well-controlled polyelectrolyte-based nanoparticles suitable for colloidal science as well as for gene delivery applications. |
| doi_str_mv | 10.1021/ac4006155 |
| format | Article |
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Chem</addtitle><date>2013-06-18</date><risdate>2013</risdate><volume>85</volume><issue>12</issue><spage>5850</spage><epage>5856</epage><pages>5850-5856</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Synthesis of surfactant–polyelectrolyte nanoparticles was carried out in a microfluidic device with a fine control over the size and the polydispersity. An anionic polysaccharide (sodium carboxymethylcellulose, CMC) solution was focused using a cationic surfactant (dodecyl trimethylammonium bromide, DTAB) solution in a microfluidic channel at selected ratios of flow rates and reagent concentrations. The methodology ensured a controlled mixing kinetics and a uniform distribution of charges at the mixing interface. The resulting nanoparticles exhibited remarkably well-defined and repeatable size distributions, with hydrodynamic diameters tunable from 50 up to 300 nm and polydispersity index around 0.1 in most cases. 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| subjects | Carboxymethylcellulose Sodium - chemistry Cellulose Electrolytes Fluid dynamics Fluid flow Fluid mechanics Hydrodynamics Microfluidics Microfluidics - methods Nanoparticles Nanoparticles - chemistry Particle Size Polydispersity Self assembly Sodium Surface-Active Agents - chemistry Surfactants |
| title | Fine Control Over the Size of Surfactant–Polyelectrolyte Nanoparticles by Hydrodynamic Flow Focusing |
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