Combination of Injection Volume Calibration by Creatinine and MS Signals’ Normalization to Overcome Urine Variability in LC-MS-Based Metabolomics Studies

It is essential to choose one preprocessing method for liquid chromatography–mass spectrometry (LC-MS)-based metabolomics studies of urine samples in order to overcome their variability. However, the commonly used normalization methods do not substantially reduce the high variabilities arising from...

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Veröffentlicht in:	Analytical chemistry (Washington) 2013-08, Vol.85 (16), p.7659-7665
Hauptverfasser:	Chen, Yanhua, Shen, Guoqing, Zhang, Ruiping, He, Jiuming, Zhang, Yi, Xu, Jing, Yang, Wei, Chen, Xiaoguang, Song, Yongmei, Abliz, Zeper
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calibration Carcinoma 256, Walker - metabolism Cell Line, Tumor Chromatography Chromatography, Liquid - methods Creatinine Creatinine - urine Liquids Male Mass spectrometry Mass Spectrometry - methods Metabolites Metabolomics Preprocessing Rats Rats, Wistar Rodents Signal transduction Spectrometry Strategy Urinalysis Urine
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