Incorporation of biphasic calcium phosphate microparticles in injectable thermoresponsive hydrogel modulates bone cell proliferation and differentiation

•Bone cells in hydrogel composite showed enhanced cell proliferation and osteogenic differentiation.•Subcutaneously implanted bone cells in hydrogel composite showed ectopic bone formation in nude mice.•The hydrogel composite can serve as an injectable material for osteoblast delivery in orthopedic...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2013-10, Vol.110, p.120-129
Hauptverfasser:	Chen, Jyh-Ping, Tsai, Ming-Jin, Liao, Han-Tsung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - chemistry Acrylic Resins Animals Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical materials Biphasic calcium phosphate Bone cells Bones Calcium phosphate Calcium Phosphates - chemistry Cell Differentiation - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chitosan - chemistry Construction Gene expression Humans Hyaluronic Acid - chemistry Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Injectable hydrogel Mice Mice, Nude Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Polymers - chemistry Scaffolds Structure-Activity Relationship Temperature Thermo-responsive Time Factors
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