Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials
We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently synthesized and studied cross-linked polyanhydrides. Various kinetic mechanisms are incorporated in the model in an attempt...
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| Veröffentlicht in: | Physical chemistry chemical physics : PCCP 2015-05, Vol.17 (2), p.13215-13222 |
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| container_title | Physical chemistry chemical physics : PCCP |
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| creator | Domanskyi, Sergii Poetz, Katie L Shipp, Devon A Privman, Vladimir |
| description | We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently synthesized and studied cross-linked polyanhydrides. Various kinetic mechanisms are incorporated in the model in an attempt to explain the experimental data for the mass loss profile. Our key finding is that the observed long induction interval is attributable to the nonlinear dependence of the degradation rate constants on the local water concentration, which essentially amounts to the breakdown of the standard rate-equation approach, potential causes for which are then discussed. Our theoretical results offer physical insights into which microscopic studies will be required to supplement the presently available macroscopic mass-loss data in order to fully understand the origin of the observed behavior.
Delayed erosion of highly cross-linked polyanhydrides is attributable to the nonlinear dependence of the degradation rates on water concentration. |
| doi_str_mv | 10.1039/c5cp00473j |
| format | Article |
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Delayed erosion of highly cross-linked polyanhydrides is attributable to the nonlinear dependence of the degradation rates on water concentration.</description><subject>Biocompatible Materials - chemistry</subject><subject>Biomaterials</subject><subject>Crosslinking</subject><subject>Degradation</subject><subject>Diffusion</subject><subject>Erosion</subject><subject>Hydrolysis</subject><subject>Intervals</subject><subject>Kinetics</subject><subject>Models, Chemical</subject><subject>Molecular Weight</subject><subject>Nonlinear Dynamics</subject><subject>Nonlinearity</subject><subject>Polyanhydrides</subject><subject>Polyanhydrides - chemistry</subject><subject>Rate constants</subject><subject>Surgical implants</subject><subject>Water - chemistry</subject><issn>1463-9076</issn><issn>1463-9084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtLxDAUhYMozji6ca_UnQjVm6ZNO0spPhlQRNcljxvt2E5qMrPovzfzcNyJZHEPJx8XzrmEHFO4pMDGVypTHUCas-kOGdKUs3gMRbq71TkfkAPvpwBAM8r2ySDJcs55TodEvaBQ89rOYl0bs_BBRRrfndBi6Uat1dhExrrgNqJHHaGzK8qaSAXp46aefQa_s00vZh-9drXGSNa2FXN0tWj8IdkzYeDRZo7I2-3Na3kfT57uHsrrSaxSSOexhpxxNAgKDEUpmchZVlAtU5kgY1oiV9yERwGMYkqGyJRzJlHTQhSGjcj5em_n7NcC_bxqa6-wacQM7cJXlI8TxnIG43-gBU14lgIN6MUaXaV1aKrO1a1wfUWhWvZflVn5vOr_McCnm70L2aLeoj-FB-BsDTivtr-_B6w6vcxx8hfDvgHn2peQ</recordid><startdate>20150528</startdate><enddate>20150528</enddate><creator>Domanskyi, Sergii</creator><creator>Poetz, Katie L</creator><creator>Shipp, Devon A</creator><creator>Privman, Vladimir</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>L7M</scope></search><sort><creationdate>20150528</creationdate><title>Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials</title><author>Domanskyi, Sergii ; 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Various kinetic mechanisms are incorporated in the model in an attempt to explain the experimental data for the mass loss profile. Our key finding is that the observed long induction interval is attributable to the nonlinear dependence of the degradation rate constants on the local water concentration, which essentially amounts to the breakdown of the standard rate-equation approach, potential causes for which are then discussed. Our theoretical results offer physical insights into which microscopic studies will be required to supplement the presently available macroscopic mass-loss data in order to fully understand the origin of the observed behavior.
Delayed erosion of highly cross-linked polyanhydrides is attributable to the nonlinear dependence of the degradation rates on water concentration.</abstract><cop>England</cop><pmid>25766671</pmid><doi>10.1039/c5cp00473j</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biocompatible Materials - chemistry Biomaterials Crosslinking Degradation Diffusion Erosion Hydrolysis Intervals Kinetics Models, Chemical Molecular Weight Nonlinear Dynamics Nonlinearity Polyanhydrides Polyanhydrides - chemistry Rate constants Surgical implants Water - chemistry |
| title | Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials |
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