Effect of testosterone incorporation on cell proliferation and differentiation for polymer–bioceramic composites
In the current study, we characterized the polycaprolactone (PCL), poly(lactic acid-co-glycolic acid) (PLGA), and biphasic calcium phosphate (BCP) composites coated with testosterone propionate (T) using Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). Osteoblastic...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2012-11, Vol.23 (11), p.2751-2759 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | da Costa, Kelen Jorge Rodrigues Passos, Joel J. Gomes, Alinne D. M. Sinisterra, Rubén D. Lanza, Célia R. M. Cortés, Maria Esperanza |
| description | In the current study, we characterized the polycaprolactone (PCL), poly(lactic acid-co-glycolic acid) (PLGA), and biphasic calcium phosphate (BCP) composites coated with testosterone propionate (T) using Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). Osteoblastic cells were seeded with PCL/BCP, PCL/BCP/T, PLGA/PCL/BCP and PLGA/PCL/BCP/T scaffolds, and cell viability, proliferation, differentiation and adhesion were analyzed. The results of physic-chemical experiments showed no displacements or suppression of bands in the FTIR spectra of scaffolds. The XRD patterns of the scaffolds showed an amorphous profile. The osteoblastic cells viability and proliferation increased in the presence of composites with testosterone over 72 h, and were significantly greater when PLGA/PCL/BCP/T scaffold was tested against PCL/BCP/T. Furthermore alkaline phosphatase production was significantly greater in the same group. In conclusion, the PLGA/PCL/BCP scaffold with testosterone could be a promising option for bone tissue applications due to its biocompatibility and its stimulatory effect on cell proliferation. |
| doi_str_mv | 10.1007/s10856-012-4733-0 |
| format | Article |
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M. ; Sinisterra, Rubén D. ; Lanza, Célia R. M. ; Cortés, Maria Esperanza</creator><creatorcontrib>da Costa, Kelen Jorge Rodrigues ; Passos, Joel J. ; Gomes, Alinne D. M. ; Sinisterra, Rubén D. ; Lanza, Célia R. M. ; Cortés, Maria Esperanza</creatorcontrib><description>In the current study, we characterized the polycaprolactone (PCL), poly(lactic acid-co-glycolic acid) (PLGA), and biphasic calcium phosphate (BCP) composites coated with testosterone propionate (T) using Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). Osteoblastic cells were seeded with PCL/BCP, PCL/BCP/T, PLGA/PCL/BCP and PLGA/PCL/BCP/T scaffolds, and cell viability, proliferation, differentiation and adhesion were analyzed. The results of physic-chemical experiments showed no displacements or suppression of bands in the FTIR spectra of scaffolds. The XRD patterns of the scaffolds showed an amorphous profile. The osteoblastic cells viability and proliferation increased in the presence of composites with testosterone over 72 h, and were significantly greater when PLGA/PCL/BCP/T scaffold was tested against PCL/BCP/T. Furthermore alkaline phosphatase production was significantly greater in the same group. In conclusion, the PLGA/PCL/BCP scaffold with testosterone could be a promising option for bone tissue applications due to its biocompatibility and its stimulatory effect on cell proliferation.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-012-4733-0</identifier><identifier>PMID: 22886580</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alkaline Phosphatase - metabolism ; Animals ; Biocompatibility ; Biocompatible Materials ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Calcium phosphate ; Cell Adhesion ; Cell Differentiation - drug effects ; Cell Proliferation - drug effects ; Cells ; Ceramics ; Ceramics - chemistry ; Chemistry and Materials Science ; Composite materials ; Composites ; Differentiation ; Glass ; Male ; Materials Science ; Medical sciences ; Microscopy, Electron, Scanning ; Natural Materials ; Polymer blends ; Polymer Sciences ; Polymers - chemistry ; Powder Diffraction ; Rats ; Rats, Wistar ; Regenerative Medicine/Tissue Engineering ; Scaffolds ; Spectra ; Spectroscopy, Fourier Transform Infrared ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Testosterone ; Testosterone - pharmacology ; Thin Films ; Tissue Scaffolds ; Viability</subject><ispartof>Journal of materials science. 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M.</creatorcontrib><creatorcontrib>Sinisterra, Rubén D.</creatorcontrib><creatorcontrib>Lanza, Célia R. M.</creatorcontrib><creatorcontrib>Cortés, Maria Esperanza</creatorcontrib><title>Effect of testosterone incorporation on cell proliferation and differentiation for polymer–bioceramic composites</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>In the current study, we characterized the polycaprolactone (PCL), poly(lactic acid-co-glycolic acid) (PLGA), and biphasic calcium phosphate (BCP) composites coated with testosterone propionate (T) using Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). Osteoblastic cells were seeded with PCL/BCP, PCL/BCP/T, PLGA/PCL/BCP and PLGA/PCL/BCP/T scaffolds, and cell viability, proliferation, differentiation and adhesion were analyzed. The results of physic-chemical experiments showed no displacements or suppression of bands in the FTIR spectra of scaffolds. The XRD patterns of the scaffolds showed an amorphous profile. The osteoblastic cells viability and proliferation increased in the presence of composites with testosterone over 72 h, and were significantly greater when PLGA/PCL/BCP/T scaffold was tested against PCL/BCP/T. Furthermore alkaline phosphatase production was significantly greater in the same group. In conclusion, the PLGA/PCL/BCP scaffold with testosterone could be a promising option for bone tissue applications due to its biocompatibility and its stimulatory effect on cell proliferation.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Calcium phosphate</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells</subject><subject>Ceramics</subject><subject>Ceramics - chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Composite materials</subject><subject>Composites</subject><subject>Differentiation</subject><subject>Glass</subject><subject>Male</subject><subject>Materials Science</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Natural Materials</subject><subject>Polymer blends</subject><subject>Polymer Sciences</subject><subject>Polymers - chemistry</subject><subject>Powder Diffraction</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Scaffolds</subject><subject>Spectra</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Costa, Kelen Jorge Rodrigues</au><au>Passos, Joel J.</au><au>Gomes, Alinne D. M.</au><au>Sinisterra, Rubén D.</au><au>Lanza, Célia R. M.</au><au>Cortés, Maria Esperanza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of testosterone incorporation on cell proliferation and differentiation for polymer–bioceramic composites</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>23</volume><issue>11</issue><spage>2751</spage><epage>2759</epage><pages>2751-2759</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>In the current study, we characterized the polycaprolactone (PCL), poly(lactic acid-co-glycolic acid) (PLGA), and biphasic calcium phosphate (BCP) composites coated with testosterone propionate (T) using Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). Osteoblastic cells were seeded with PCL/BCP, PCL/BCP/T, PLGA/PCL/BCP and PLGA/PCL/BCP/T scaffolds, and cell viability, proliferation, differentiation and adhesion were analyzed. The results of physic-chemical experiments showed no displacements or suppression of bands in the FTIR spectra of scaffolds. The XRD patterns of the scaffolds showed an amorphous profile. The osteoblastic cells viability and proliferation increased in the presence of composites with testosterone over 72 h, and were significantly greater when PLGA/PCL/BCP/T scaffold was tested against PCL/BCP/T. Furthermore alkaline phosphatase production was significantly greater in the same group. In conclusion, the PLGA/PCL/BCP scaffold with testosterone could be a promising option for bone tissue applications due to its biocompatibility and its stimulatory effect on cell proliferation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22886580</pmid><doi>10.1007/s10856-012-4733-0</doi><tpages>9</tpages></addata></record> |
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| subjects | Alkaline Phosphatase - metabolism Animals Biocompatibility Biocompatible Materials Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Calcium phosphate Cell Adhesion Cell Differentiation - drug effects Cell Proliferation - drug effects Cells Ceramics Ceramics - chemistry Chemistry and Materials Science Composite materials Composites Differentiation Glass Male Materials Science Medical sciences Microscopy, Electron, Scanning Natural Materials Polymer blends Polymer Sciences Polymers - chemistry Powder Diffraction Rats Rats, Wistar Regenerative Medicine/Tissue Engineering Scaffolds Spectra Spectroscopy, Fourier Transform Infrared Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Testosterone Testosterone - pharmacology Thin Films Tissue Scaffolds Viability |
| title | Effect of testosterone incorporation on cell proliferation and differentiation for polymer–bioceramic composites |
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