In vitro evaluation of electrospun PCL/nanoclay composite scaffold for bone tissue engineering
Polycaprolactone (PCL) is a widely accepted synthetic biodegradable polymer for tissue engineering, however its use in hard tissue engineering is limited because of its inadequate mechanical strength and low bioactivity. In this study, we used halloysite nanoclay (NC) as an inorganic filler material...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2012-07, Vol.23 (7), p.1749-1761 |
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| creator | Nitya, Ganesh Nair, Greeshma T. Mony, Ullas Chennazhi, Krishna Prasad Nair, Shantikumar V. |
| description | Polycaprolactone (PCL) is a widely accepted synthetic biodegradable polymer for tissue engineering, however its use in hard tissue engineering is limited because of its inadequate mechanical strength and low bioactivity. In this study, we used halloysite nanoclay (NC) as an inorganic filler material to prepare PCL/NC fibrous scaffolds via electrospinning technique after intercalating NC within PCL by solution intercalation method. The obtained nanofibrous mat was found to be mechanically superior to PCL fibrous scaffolds. These scaffolds allowed greater protein adsorption and enhanced mineralization when incubated in simulated body fluid. Moreover, our results indicated that human mesenchymal stem cells (hMSCs) seeded on these scaffolds were viable and could proliferate faster than in PCL scaffolds as confirmed by fluorescence and scanning electron microscopic observations. Further, osteogenic differentiation of hMSCs on nanoclay embedded scaffolds was demonstrated by an increase in alkaline phosphatase activity when compared to PCL scaffold without nanoclay. All of these results suggest the potential of PCL/NC scaffolds for bone tissue engineering. |
| doi_str_mv | 10.1007/s10856-012-4647-x |
| format | Article |
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In this study, we used halloysite nanoclay (NC) as an inorganic filler material to prepare PCL/NC fibrous scaffolds via electrospinning technique after intercalating NC within PCL by solution intercalation method. The obtained nanofibrous mat was found to be mechanically superior to PCL fibrous scaffolds. These scaffolds allowed greater protein adsorption and enhanced mineralization when incubated in simulated body fluid. Moreover, our results indicated that human mesenchymal stem cells (hMSCs) seeded on these scaffolds were viable and could proliferate faster than in PCL scaffolds as confirmed by fluorescence and scanning electron microscopic observations. Further, osteogenic differentiation of hMSCs on nanoclay embedded scaffolds was demonstrated by an increase in alkaline phosphatase activity when compared to PCL scaffold without nanoclay. All of these results suggest the potential of PCL/NC scaffolds for bone tissue engineering.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-012-4647-x</identifier><identifier>PMID: 22552826</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adsorption ; Aluminum Silicates ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biotechnology ; Bone and Bones - cytology ; Bones ; Cell Adhesion ; Cell Differentiation ; Ceramics ; Chemistry and Materials Science ; Composites ; Electrospinning ; Fundamental and applied biological sciences. Psychology ; Glass ; Health. Pharmaceutical industry ; Humans ; Industrial applications and implications. Economical aspects ; Materials Science ; Medical sciences ; Microscopy, Electron, Scanning ; Miscellaneous ; Nanocomposites ; Nanomaterials ; Nanostructure ; Natural Materials ; Numerical control ; Polymer Sciences ; Polymers ; Regenerative Medicine/Tissue Engineering ; Scaffolds ; Scanning electron microscopy ; Spectroscopy, Fourier Transform Infrared ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thin Films ; Tissue Engineering ; X-Ray Diffraction</subject><ispartof>Journal of materials science. 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Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Polycaprolactone (PCL) is a widely accepted synthetic biodegradable polymer for tissue engineering, however its use in hard tissue engineering is limited because of its inadequate mechanical strength and low bioactivity. In this study, we used halloysite nanoclay (NC) as an inorganic filler material to prepare PCL/NC fibrous scaffolds via electrospinning technique after intercalating NC within PCL by solution intercalation method. The obtained nanofibrous mat was found to be mechanically superior to PCL fibrous scaffolds. These scaffolds allowed greater protein adsorption and enhanced mineralization when incubated in simulated body fluid. Moreover, our results indicated that human mesenchymal stem cells (hMSCs) seeded on these scaffolds were viable and could proliferate faster than in PCL scaffolds as confirmed by fluorescence and scanning electron microscopic observations. Further, osteogenic differentiation of hMSCs on nanoclay embedded scaffolds was demonstrated by an increase in alkaline phosphatase activity when compared to PCL scaffold without nanoclay. All of these results suggest the potential of PCL/NC scaffolds for bone tissue engineering.</description><subject>Adsorption</subject><subject>Aluminum Silicates</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biotechnology</subject><subject>Bone and Bones - cytology</subject><subject>Bones</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Electrospinning</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glass</subject><subject>Health. Pharmaceutical industry</subject><subject>Humans</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Materials Science</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Miscellaneous</subject><subject>Nanocomposites</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Natural Materials</subject><subject>Numerical control</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Scaffolds</subject><subject>Scanning electron microscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nitya, Ganesh</au><au>Nair, Greeshma T.</au><au>Mony, Ullas</au><au>Chennazhi, Krishna Prasad</au><au>Nair, Shantikumar V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of electrospun PCL/nanoclay composite scaffold for bone tissue engineering</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>23</volume><issue>7</issue><spage>1749</spage><epage>1761</epage><pages>1749-1761</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Polycaprolactone (PCL) is a widely accepted synthetic biodegradable polymer for tissue engineering, however its use in hard tissue engineering is limited because of its inadequate mechanical strength and low bioactivity. In this study, we used halloysite nanoclay (NC) as an inorganic filler material to prepare PCL/NC fibrous scaffolds via electrospinning technique after intercalating NC within PCL by solution intercalation method. The obtained nanofibrous mat was found to be mechanically superior to PCL fibrous scaffolds. These scaffolds allowed greater protein adsorption and enhanced mineralization when incubated in simulated body fluid. Moreover, our results indicated that human mesenchymal stem cells (hMSCs) seeded on these scaffolds were viable and could proliferate faster than in PCL scaffolds as confirmed by fluorescence and scanning electron microscopic observations. Further, osteogenic differentiation of hMSCs on nanoclay embedded scaffolds was demonstrated by an increase in alkaline phosphatase activity when compared to PCL scaffold without nanoclay. All of these results suggest the potential of PCL/NC scaffolds for bone tissue engineering.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22552826</pmid><doi>10.1007/s10856-012-4647-x</doi><tpages>13</tpages></addata></record> |
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| subjects | Adsorption Aluminum Silicates Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Biotechnology Bone and Bones - cytology Bones Cell Adhesion Cell Differentiation Ceramics Chemistry and Materials Science Composites Electrospinning Fundamental and applied biological sciences. Psychology Glass Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Materials Science Medical sciences Microscopy, Electron, Scanning Miscellaneous Nanocomposites Nanomaterials Nanostructure Natural Materials Numerical control Polymer Sciences Polymers Regenerative Medicine/Tissue Engineering Scaffolds Scanning electron microscopy Spectroscopy, Fourier Transform Infrared Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Tissue Engineering X-Ray Diffraction |
| title | In vitro evaluation of electrospun PCL/nanoclay composite scaffold for bone tissue engineering |
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