Syndecan-1 in Acute Decompensated Heart Failure – Association With Renal Function and Mortality
Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx...
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| Veröffentlicht in: | Circulation Journal 2015/06/25, Vol.79(7), pp.1511-1519 |
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| creator | Fernanda Macedo de Oliveira Neves Meneses, Gdayllon Cavalcante Sousa, Nazareth Ermínia Araujo Ramon Róseo Paula Pessoa Bezerra de Menezes Parahyba, Marcelo Coelho Martins, Alice Maria Costa Libório, Alexandre Braga |
| description | Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx damage plays in HF patients and its association with AKI and mortality.Methods and Results:We measured several endothelial biomarkers in 201 consecutive patients with acute decompensated HF (ADHF) during emergency department (ED) admission. In-hospital mortality, AKI development and 6-month mortality rates were assessed. ADHF patients with worsening renal function had higher levels of syndecan-1 but not those patients with stable chronic kidney disease. Syndecan-1 levels during ED admission were predictive for AKI during the hospital stay (AUC 0.741, P |
| doi_str_mv | 10.1253/circj.CJ-14-1195 |
| format | Article |
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HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx damage plays in HF patients and its association with AKI and mortality.Methods and Results:We measured several endothelial biomarkers in 201 consecutive patients with acute decompensated HF (ADHF) during emergency department (ED) admission. In-hospital mortality, AKI development and 6-month mortality rates were assessed. ADHF patients with worsening renal function had higher levels of syndecan-1 but not those patients with stable chronic kidney disease. Syndecan-1 levels during ED admission were predictive for AKI during the hospital stay (AUC 0.741, P<0.001) and had an even better discriminatory capacity in more severe AKI (AUC 0.812, P<0.001). Additionally, after adjusting for several confounding factors, including biomarkers of endothelial function and endothelial cell activation, syndecan-1 remained associated with in-hospital mortality rates. On a Cox multivariate analysis regression, syndecan-1 was associated with 6-month mortality rates.Conclusions:The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality. Its association with mortality is strong after 6-month follow-up. (Circ J 2015; 79: 1511–1519)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-14-1195</identifier><identifier>PMID: 25891890</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute Disease ; Acute kidney injury ; Acute Kidney Injury - blood ; Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Aged ; Biomarkers - blood ; Brazil ; Emergency Service, Hospital ; Endothelial function ; Female ; Follow-Up Studies ; Heart failure ; Heart Failure - blood ; Heart Failure - complications ; Heart Failure - mortality ; Hospital Mortality ; Humans ; Kidney - metabolism ; Male ; Middle Aged ; Syndecan-1 ; Syndecan-1 - blood</subject><ispartof>Circulation Journal, 2015/06/25, Vol.79(7), pp.1511-1519</ispartof><rights>2015 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-e5f3138b75b040cafc7f2553e98f79a95bf30206f3377bb152e144fdcf49e41f3</citedby><cites>FETCH-LOGICAL-c494t-e5f3138b75b040cafc7f2553e98f79a95bf30206f3377bb152e144fdcf49e41f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25891890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernanda Macedo de Oliveira Neves</creatorcontrib><creatorcontrib>Meneses, Gdayllon Cavalcante</creatorcontrib><creatorcontrib>Sousa, Nazareth Ermínia Araujo</creatorcontrib><creatorcontrib>Ramon Róseo Paula Pessoa Bezerra de Menezes</creatorcontrib><creatorcontrib>Parahyba, Marcelo Coelho</creatorcontrib><creatorcontrib>Martins, Alice Maria Costa</creatorcontrib><creatorcontrib>Libório, Alexandre Braga</creatorcontrib><title>Syndecan-1 in Acute Decompensated Heart Failure – Association With Renal Function and Mortality</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx damage plays in HF patients and its association with AKI and mortality.Methods and Results:We measured several endothelial biomarkers in 201 consecutive patients with acute decompensated HF (ADHF) during emergency department (ED) admission. In-hospital mortality, AKI development and 6-month mortality rates were assessed. ADHF patients with worsening renal function had higher levels of syndecan-1 but not those patients with stable chronic kidney disease. Syndecan-1 levels during ED admission were predictive for AKI during the hospital stay (AUC 0.741, P<0.001) and had an even better discriminatory capacity in more severe AKI (AUC 0.812, P<0.001). Additionally, after adjusting for several confounding factors, including biomarkers of endothelial function and endothelial cell activation, syndecan-1 remained associated with in-hospital mortality rates. On a Cox multivariate analysis regression, syndecan-1 was associated with 6-month mortality rates.Conclusions:The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality. Its association with mortality is strong after 6-month follow-up. (Circ J 2015; 79: 1511–1519)</description><subject>Acute Disease</subject><subject>Acute kidney injury</subject><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Brazil</subject><subject>Emergency Service, Hospital</subject><subject>Endothelial function</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - mortality</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Syndecan-1</subject><subject>Syndecan-1 - blood</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOGzEUhq2qCFLKvqvKy24GfM2Ml1FKSCMQEhSxtDye4-Jo4kltzyK7vANv2L4IuRE25xwdff-_-BD6RsklZZJfWR_t_HI8K6goKFXyExpQLspCVIx83t3DQlWCn6EvKc0JYYpIdYrOmKwUrRQZIPu4Cg1YEwqKfcAj22fAP8F2iyWEZDI0eAomZjwxvu0j_F-v_61f8SilznqTfRfws88v-AGCafGkD3b3M6HBd13MpvV59RWdONMmuDjsc_Q0uf49nha39ze_xqPbwgolcgHSccqrupQ1EcQaZ0vHpOSgKlcqo2TtOGFk6Dgvy7qmkgEVwjXWCQWCOn6Ofux7l7H720PKeuGThbY1Abo-aTpUjClOBdmgZI_a2KUUwell9AsTV5oSvVWrd2r1eKap0Fu1m8j3Q3tfL6A5Bt5dboDJHpinbP7AEdjY87aFQ2OpdLkdH80fwIuJGgJ_A7O6kPI</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Fernanda Macedo de Oliveira Neves</creator><creator>Meneses, Gdayllon Cavalcante</creator><creator>Sousa, Nazareth Ermínia Araujo</creator><creator>Ramon Róseo Paula Pessoa Bezerra de Menezes</creator><creator>Parahyba, Marcelo Coelho</creator><creator>Martins, Alice Maria Costa</creator><creator>Libório, Alexandre Braga</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Syndecan-1 in Acute Decompensated Heart Failure – Association With Renal Function and Mortality</title><author>Fernanda Macedo de Oliveira Neves ; Meneses, Gdayllon Cavalcante ; Sousa, Nazareth Ermínia Araujo ; Ramon Róseo Paula Pessoa Bezerra de Menezes ; Parahyba, Marcelo Coelho ; Martins, Alice Maria Costa ; Libório, Alexandre Braga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-e5f3138b75b040cafc7f2553e98f79a95bf30206f3377bb152e144fdcf49e41f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Disease</topic><topic>Acute kidney injury</topic><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Brazil</topic><topic>Emergency Service, Hospital</topic><topic>Endothelial function</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - mortality</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Syndecan-1</topic><topic>Syndecan-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernanda Macedo de Oliveira Neves</creatorcontrib><creatorcontrib>Meneses, Gdayllon Cavalcante</creatorcontrib><creatorcontrib>Sousa, Nazareth Ermínia Araujo</creatorcontrib><creatorcontrib>Ramon Róseo Paula Pessoa Bezerra de Menezes</creatorcontrib><creatorcontrib>Parahyba, Marcelo Coelho</creatorcontrib><creatorcontrib>Martins, Alice Maria Costa</creatorcontrib><creatorcontrib>Libório, Alexandre Braga</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernanda Macedo de Oliveira Neves</au><au>Meneses, Gdayllon Cavalcante</au><au>Sousa, Nazareth Ermínia Araujo</au><au>Ramon Róseo Paula Pessoa Bezerra de Menezes</au><au>Parahyba, Marcelo Coelho</au><au>Martins, Alice Maria Costa</au><au>Libório, Alexandre Braga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syndecan-1 in Acute Decompensated Heart Failure – Association With Renal Function and Mortality</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2015</date><risdate>2015</risdate><volume>79</volume><issue>7</issue><spage>1511</spage><epage>1519</epage><pages>1511-1519</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:Heart failure (HF) is a leading cause of hospitalization throughout the world, and the mortality rate remains elevated. HF is frequently complicated by acute kidney injury (AKI), worsening the patient’s prognosis. There have been no studies evaluating the role that endothelial glycocalyx damage plays in HF patients and its association with AKI and mortality.Methods and Results:We measured several endothelial biomarkers in 201 consecutive patients with acute decompensated HF (ADHF) during emergency department (ED) admission. In-hospital mortality, AKI development and 6-month mortality rates were assessed. ADHF patients with worsening renal function had higher levels of syndecan-1 but not those patients with stable chronic kidney disease. Syndecan-1 levels during ED admission were predictive for AKI during the hospital stay (AUC 0.741, P<0.001) and had an even better discriminatory capacity in more severe AKI (AUC 0.812, P<0.001). Additionally, after adjusting for several confounding factors, including biomarkers of endothelial function and endothelial cell activation, syndecan-1 remained associated with in-hospital mortality rates. On a Cox multivariate analysis regression, syndecan-1 was associated with 6-month mortality rates.Conclusions:The concentration of syndecan-1, a marker of glycocalyx damage measured during ED admission, is valuable in assessing the risk of developing AKI and in-hospital mortality. Its association with mortality is strong after 6-month follow-up. (Circ J 2015; 79: 1511–1519)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>25891890</pmid><doi>10.1253/circj.CJ-14-1195</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Acute kidney injury Acute Kidney Injury - blood Acute Kidney Injury - etiology Acute Kidney Injury - mortality Aged Biomarkers - blood Brazil Emergency Service, Hospital Endothelial function Female Follow-Up Studies Heart failure Heart Failure - blood Heart Failure - complications Heart Failure - mortality Hospital Mortality Humans Kidney - metabolism Male Middle Aged Syndecan-1 Syndecan-1 - blood |
| title | Syndecan-1 in Acute Decompensated Heart Failure – Association With Renal Function and Mortality |
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