Buprenorphine for pain relief in mice: repeated injections vs sustained-release depot formulation

Sustained-release formulations of analgesic drugs are promising alternatives to repeated drug injections. Here, we compared a sustained-release formulation of buprenorphine (SB, 2.2 mg/kg) with a standard protocol of three injections of buprenorphine (Temgesic, 0.1 mg/kg/8 h) in mice. Buprenorphine...

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Veröffentlicht in:	Laboratory animals (London) 2015-07, Vol.49 (3), p.177-187
Hauptverfasser:	Jirkof, P, Tourvieille, A, Cinelli, P, Arras, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Animals Buprenorphine - administration & dosage Delayed-Action Preparations Female Hot Temperature - adverse effects Injections, Subcutaneous Laparotomy Mice Mice, Inbred C57BL Pain - drug therapy Pain Management - methods Pain Measurement
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