Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease
Objective Open surgery has given way to endovascular grafting in patients with aortoiliac occlusive disease. The growing use of endovascular grafts means that fewer patients with aortoiliac occlusive disease have open surgery. The declining open surgery caseload challenges the surgeon's operati...
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creator | Bredahl, Kim, MD, PhD Jensen, Leif Panduro, MD Schroeder, Torben V., MD, DMSc Sillesen, Henrik, MD, DMSc Nielsen, Henrik Eiberg, Jonas P., MD, PhD |
description | Objective Open surgery has given way to endovascular grafting in patients with aortoiliac occlusive disease. The growing use of endovascular grafts means that fewer patients with aortoiliac occlusive disease have open surgery. The declining open surgery caseload challenges the surgeon's operative skills, particularly because open surgery is increasingly used in those patients who are unsuitable for endovascular repair and hence technically more demanding. We assessed the early outcome after aortic bifurcated bypass procedures during two decades of growing endovascular activity and identified preoperative risk factors. Methods Data on patients with chronic limb ischemia were prospectively collected during a 20-year period (1993 to 2012). The data were obtained from the Danish Vascular Registry, assessed, and merged with data from The Danish Civil Registration System. Results We identified 3623 aortobifemoral and 144 aortobiiliac bypass procedures. The annual caseload fell from 323 to 106 during the study period, but the 30-day mortality at 3.6% (95% confidence interval [CI], 3.0-4.1) and the 30-day major complication rate remained constant at 20% (95% CI, 18-21). Gangrene (odds ratio [OR], 3.3; 95% CI, 1.7-6.5; P = .005) was the most significant risk factor for 30-day mortality, followed by renal insufficiency (OR, 2.5; 95% CI, 1.1-5.8; P = .035) and cardiac disease (OR, 2.1; 95% CI, 1.4-3.1; P < .001). Multiorgan failure, mesenteric ischemia, need for dialysis, and cardiac complications were the most lethal complications, with mortality rates of 94%, 44%, 38%, and 34%, respectively. Conclusions Aortic bifurcated bypass is a high-risk procedure. Although open surgery has increasingly given way to endovascular repair, 30-day outcomes have remained stable during the past decade. Thus, it is still acceptable to consider an aortic bifurcated bypass whenever endovascular management is not feasible. |
doi_str_mv | 10.1016/j.jvs.2015.02.025 |
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The growing use of endovascular grafts means that fewer patients with aortoiliac occlusive disease have open surgery. The declining open surgery caseload challenges the surgeon's operative skills, particularly because open surgery is increasingly used in those patients who are unsuitable for endovascular repair and hence technically more demanding. We assessed the early outcome after aortic bifurcated bypass procedures during two decades of growing endovascular activity and identified preoperative risk factors. Methods Data on patients with chronic limb ischemia were prospectively collected during a 20-year period (1993 to 2012). The data were obtained from the Danish Vascular Registry, assessed, and merged with data from The Danish Civil Registration System. Results We identified 3623 aortobifemoral and 144 aortobiiliac bypass procedures. The annual caseload fell from 323 to 106 during the study period, but the 30-day mortality at 3.6% (95% confidence interval [CI], 3.0-4.1) and the 30-day major complication rate remained constant at 20% (95% CI, 18-21). Gangrene (odds ratio [OR], 3.3; 95% CI, 1.7-6.5; P = .005) was the most significant risk factor for 30-day mortality, followed by renal insufficiency (OR, 2.5; 95% CI, 1.1-5.8; P = .035) and cardiac disease (OR, 2.1; 95% CI, 1.4-3.1; P < .001). Multiorgan failure, mesenteric ischemia, need for dialysis, and cardiac complications were the most lethal complications, with mortality rates of 94%, 44%, 38%, and 34%, respectively. Conclusions Aortic bifurcated bypass is a high-risk procedure. Although open surgery has increasingly given way to endovascular repair, 30-day outcomes have remained stable during the past decade. Thus, it is still acceptable to consider an aortic bifurcated bypass whenever endovascular management is not feasible.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2015.02.025</identifier><identifier>PMID: 26115920</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aortic Diseases - diagnosis ; Aortic Diseases - mortality ; Aortic Diseases - physiopathology ; Aortic Diseases - surgery ; Arterial Occlusive Diseases - diagnosis ; Arterial Occlusive Diseases - mortality ; Arterial Occlusive Diseases - physiopathology ; Arterial Occlusive Diseases - surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - instrumentation ; Blood Vessel Prosthesis Implantation - mortality ; Chronic Disease ; Constriction, Pathologic ; Denmark ; Female ; Humans ; Iliac Artery - physiopathology ; Iliac Artery - surgery ; Ischemia - diagnosis ; Ischemia - mortality ; Ischemia - physiopathology ; Ischemia - surgery ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Postoperative Complications - mortality ; Prospective Studies ; Registries ; Risk Factors ; Surgery ; Time Factors ; Treatment Outcome ; Vascular Patency</subject><ispartof>Journal of vascular surgery, 2015-07, Vol.62 (1), p.75-82</ispartof><rights>Society for Vascular Surgery</rights><rights>2015 Society for Vascular Surgery</rights><rights>Copyright © 2015 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-d0efc851cf8fe7d79301bab3d3dacee087b0e1822f7e382f72b620697c0e4da13</citedby><cites>FETCH-LOGICAL-c517t-d0efc851cf8fe7d79301bab3d3dacee087b0e1822f7e382f72b620697c0e4da13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jvs.2015.02.025$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26115920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bredahl, Kim, MD, PhD</creatorcontrib><creatorcontrib>Jensen, Leif Panduro, MD</creatorcontrib><creatorcontrib>Schroeder, Torben V., MD, DMSc</creatorcontrib><creatorcontrib>Sillesen, Henrik, MD, DMSc</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Eiberg, Jonas P., MD, PhD</creatorcontrib><title>Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>Objective Open surgery has given way to endovascular grafting in patients with aortoiliac occlusive disease. The growing use of endovascular grafts means that fewer patients with aortoiliac occlusive disease have open surgery. The declining open surgery caseload challenges the surgeon's operative skills, particularly because open surgery is increasingly used in those patients who are unsuitable for endovascular repair and hence technically more demanding. We assessed the early outcome after aortic bifurcated bypass procedures during two decades of growing endovascular activity and identified preoperative risk factors. Methods Data on patients with chronic limb ischemia were prospectively collected during a 20-year period (1993 to 2012). The data were obtained from the Danish Vascular Registry, assessed, and merged with data from The Danish Civil Registration System. Results We identified 3623 aortobifemoral and 144 aortobiiliac bypass procedures. The annual caseload fell from 323 to 106 during the study period, but the 30-day mortality at 3.6% (95% confidence interval [CI], 3.0-4.1) and the 30-day major complication rate remained constant at 20% (95% CI, 18-21). Gangrene (odds ratio [OR], 3.3; 95% CI, 1.7-6.5; P = .005) was the most significant risk factor for 30-day mortality, followed by renal insufficiency (OR, 2.5; 95% CI, 1.1-5.8; P = .035) and cardiac disease (OR, 2.1; 95% CI, 1.4-3.1; P < .001). Multiorgan failure, mesenteric ischemia, need for dialysis, and cardiac complications were the most lethal complications, with mortality rates of 94%, 44%, 38%, and 34%, respectively. Conclusions Aortic bifurcated bypass is a high-risk procedure. Although open surgery has increasingly given way to endovascular repair, 30-day outcomes have remained stable during the past decade. Thus, it is still acceptable to consider an aortic bifurcated bypass whenever endovascular management is not feasible.</description><subject>Aged</subject><subject>Aortic Diseases - diagnosis</subject><subject>Aortic Diseases - mortality</subject><subject>Aortic Diseases - physiopathology</subject><subject>Aortic Diseases - surgery</subject><subject>Arterial Occlusive Diseases - diagnosis</subject><subject>Arterial Occlusive Diseases - mortality</subject><subject>Arterial Occlusive Diseases - physiopathology</subject><subject>Arterial Occlusive Diseases - surgery</subject><subject>Blood Vessel Prosthesis</subject><subject>Blood Vessel Prosthesis Implantation - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - instrumentation</subject><subject>Blood Vessel Prosthesis Implantation - mortality</subject><subject>Chronic Disease</subject><subject>Constriction, Pathologic</subject><subject>Denmark</subject><subject>Female</subject><subject>Humans</subject><subject>Iliac Artery - physiopathology</subject><subject>Iliac Artery - surgery</subject><subject>Ischemia - diagnosis</subject><subject>Ischemia - mortality</subject><subject>Ischemia - physiopathology</subject><subject>Ischemia - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Postoperative Complications - mortality</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Patency</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-L1DAQx4Mo3nr6B_giefSl60y6bVoEQY7zB9zhw53gW0iTKaZ2mzVpF_a_d8qePvhwMCSBfOZL8hkhXiNsEbB-N2yHY94qwGoLiqt6IjYIrS7qBtqnYgN6h0WlcHchXuQ8ACBWjX4uLlTNp1bBRky3Mc12DPNJ2slLF_eHMTg7hzhlafuZkrRMBCe70C-Jb8jL7nSwOctDio78kijLPibpfqY4MbjyMYzBOhmdG5ccjiR9yGQzvRTPejtmevWwX4rvn67vr74UN98-f736eFO4CvVceKDeNRW6vulJe92WgJ3tSl9664ig0R0QNkr1msqGV9XVCupWO6Cdt1heirfnXH7j74XybPYhOxpHO1FcssG6ZQEc2zCKZ9SlmHOi3hxS2Nt0Mghm1WwGw5rNqtmA4qq4581D_NLtyf_r-OuVgfdngPiTx0DJZBdoYl0hkZuNj-HR-A__dbsxsFo7_qIT5SEuaWJ7Bk3mBnO3znkdM1YASlc_yj_DvaWp</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Bredahl, Kim, MD, PhD</creator><creator>Jensen, Leif Panduro, MD</creator><creator>Schroeder, Torben V., MD, DMSc</creator><creator>Sillesen, Henrik, MD, DMSc</creator><creator>Nielsen, Henrik</creator><creator>Eiberg, Jonas P., MD, PhD</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease</title><author>Bredahl, Kim, MD, PhD ; Jensen, Leif Panduro, MD ; Schroeder, Torben V., MD, DMSc ; Sillesen, Henrik, MD, DMSc ; Nielsen, Henrik ; Eiberg, Jonas P., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-d0efc851cf8fe7d79301bab3d3dacee087b0e1822f7e382f72b620697c0e4da13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aortic Diseases - diagnosis</topic><topic>Aortic Diseases - mortality</topic><topic>Aortic Diseases - physiopathology</topic><topic>Aortic Diseases - surgery</topic><topic>Arterial Occlusive Diseases - diagnosis</topic><topic>Arterial Occlusive Diseases - mortality</topic><topic>Arterial Occlusive Diseases - physiopathology</topic><topic>Arterial Occlusive Diseases - surgery</topic><topic>Blood Vessel Prosthesis</topic><topic>Blood Vessel Prosthesis Implantation - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - instrumentation</topic><topic>Blood Vessel Prosthesis Implantation - mortality</topic><topic>Chronic Disease</topic><topic>Constriction, Pathologic</topic><topic>Denmark</topic><topic>Female</topic><topic>Humans</topic><topic>Iliac Artery - physiopathology</topic><topic>Iliac Artery - surgery</topic><topic>Ischemia - diagnosis</topic><topic>Ischemia - mortality</topic><topic>Ischemia - physiopathology</topic><topic>Ischemia - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Postoperative Complications - mortality</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Patency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bredahl, Kim, MD, PhD</creatorcontrib><creatorcontrib>Jensen, Leif Panduro, MD</creatorcontrib><creatorcontrib>Schroeder, Torben V., MD, DMSc</creatorcontrib><creatorcontrib>Sillesen, Henrik, MD, DMSc</creatorcontrib><creatorcontrib>Nielsen, Henrik</creatorcontrib><creatorcontrib>Eiberg, Jonas P., MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bredahl, Kim, MD, PhD</au><au>Jensen, Leif Panduro, MD</au><au>Schroeder, Torben V., MD, DMSc</au><au>Sillesen, Henrik, MD, DMSc</au><au>Nielsen, Henrik</au><au>Eiberg, Jonas P., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>62</volume><issue>1</issue><spage>75</spage><epage>82</epage><pages>75-82</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><abstract>Objective Open surgery has given way to endovascular grafting in patients with aortoiliac occlusive disease. The growing use of endovascular grafts means that fewer patients with aortoiliac occlusive disease have open surgery. The declining open surgery caseload challenges the surgeon's operative skills, particularly because open surgery is increasingly used in those patients who are unsuitable for endovascular repair and hence technically more demanding. We assessed the early outcome after aortic bifurcated bypass procedures during two decades of growing endovascular activity and identified preoperative risk factors. Methods Data on patients with chronic limb ischemia were prospectively collected during a 20-year period (1993 to 2012). The data were obtained from the Danish Vascular Registry, assessed, and merged with data from The Danish Civil Registration System. Results We identified 3623 aortobifemoral and 144 aortobiiliac bypass procedures. The annual caseload fell from 323 to 106 during the study period, but the 30-day mortality at 3.6% (95% confidence interval [CI], 3.0-4.1) and the 30-day major complication rate remained constant at 20% (95% CI, 18-21). Gangrene (odds ratio [OR], 3.3; 95% CI, 1.7-6.5; P = .005) was the most significant risk factor for 30-day mortality, followed by renal insufficiency (OR, 2.5; 95% CI, 1.1-5.8; P = .035) and cardiac disease (OR, 2.1; 95% CI, 1.4-3.1; P < .001). Multiorgan failure, mesenteric ischemia, need for dialysis, and cardiac complications were the most lethal complications, with mortality rates of 94%, 44%, 38%, and 34%, respectively. Conclusions Aortic bifurcated bypass is a high-risk procedure. Although open surgery has increasingly given way to endovascular repair, 30-day outcomes have remained stable during the past decade. Thus, it is still acceptable to consider an aortic bifurcated bypass whenever endovascular management is not feasible.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26115920</pmid><doi>10.1016/j.jvs.2015.02.025</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aortic Diseases - diagnosis Aortic Diseases - mortality Aortic Diseases - physiopathology Aortic Diseases - surgery Arterial Occlusive Diseases - diagnosis Arterial Occlusive Diseases - mortality Arterial Occlusive Diseases - physiopathology Arterial Occlusive Diseases - surgery Blood Vessel Prosthesis Blood Vessel Prosthesis Implantation - adverse effects Blood Vessel Prosthesis Implantation - instrumentation Blood Vessel Prosthesis Implantation - mortality Chronic Disease Constriction, Pathologic Denmark Female Humans Iliac Artery - physiopathology Iliac Artery - surgery Ischemia - diagnosis Ischemia - mortality Ischemia - physiopathology Ischemia - surgery Male Middle Aged Multivariate Analysis Odds Ratio Postoperative Complications - mortality Prospective Studies Registries Risk Factors Surgery Time Factors Treatment Outcome Vascular Patency |
title | Mortality and complications after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease |
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