The impact of biological therapy on regulatory T cells in rheumatoid arthritis

Regulatory T cells (Treg) are functionally defective in patients with RA. Restoring their function may not only control inflammation but also restore tolerance in these patients. Biologic therapies have been tremendously successful in treating RA. Here we review numerous reports suggesting that thes...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2015-05, Vol.54 (5), p.768-775
Hauptverfasser:	Byng-Maddick, Rachel, Ehrenstein, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Biological Products - pharmacology Biological Products - therapeutic use Biological Therapy Humans Immune Tolerance - drug effects Immune Tolerance - physiology Inflammation - pathology Inflammation - physiopathology Inflammation - prevention & control T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - drug effects
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