Health-related quality of life following pediatric critical illness
Purpose The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implement...
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| Veröffentlicht in: | Intensive care medicine 2015-07, Vol.41 (7), p.1235-1246 |
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| container_title | Intensive care medicine |
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| creator | Aspesberro, François Mangione-Smith, Rita Zimmerman, Jerry J. |
| description | Purpose
The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implemented in pediatric critical care studies to date.
Methods
This was a focused review of the literature from 1980 to 2015 based on a search of EMBASE/PubMed, MEDLINE and PsycInfo assessing trends and determinants of HRQL outcomes in children surviving critical illness. We also evaluated the psychometric properties of the HRQL instruments used in the studies identified by examining each measure’s reported reliability, validity and sensitivity to clinical change.
Results
The literature search identified 253 pediatric articles for potential inclusion in the review, among which data from 78 studies were ultimately selected for inclusion. Of the 22 measures utilized in the studies reviewed, only four demonstrated excellent psychometric properties for use in pediatric critical care trials. Trends in HRQL identified in the studies reviewed suggest significant ongoing morbidity for children surviving critical illness. Key determinants of poor HRQL outcomes include reason for PICU admission (sepsis, meningoencephalitis, trauma), antecedents (chronic comorbid conditions), treatments received (prolonged cardiopulmonary resuscitation, long-stay patients, invasive technology), psychological outcomes (post-traumatic stress disorder, parent anxiety/depression) and social and environmental characteristics (low socioeconomic status, parental education and functioning).
Conclusions
Validated pediatric HRQL instruments are now available. Significant impact on HRQL has been demonstrated in acute and acute on chronic critical illness. Future pediatric critical care interventional trials should include both mortality as well as long-term HRQL measurements to truly ascertain the full impact of critical illness in children. |
| doi_str_mv | 10.1007/s00134-015-3780-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1691593699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A724289522</galeid><sourcerecordid>A724289522</sourcerecordid><originalsourceid>FETCH-LOGICAL-c613t-7fd0820d2af553a410c684537832a850dd1ee5e6cfe2860f53189ae1b8171f683</originalsourceid><addsrcrecordid>eNp1kU1vVCEUhomxsWP1B7gxN3HjhpYDl4-7bCZqTZp0U9eEcg8jDXOZwr0x_fcyTv3MGBYk8LxvDjyEvAF2Dozpi8oYiJ4ykFRow6h-RlbQC06BC_OcrJjoOe1Vz0_Jy1rvG62VhBfklEsjQQywIusrdGn-SgsmN-PYPSwuxfmxy6FLMWAXckr5W5w23Q7H6OYSfedLnKN3qYspTVjrK3ISXKr4-mk_I18-frhdX9Hrm0-f15fX1CsQM9VhZIazkbsgpXA9MK9ML9vkgjsj2TgCokTlA3KjWJACzOAQ7gxoCMqIM_L-0Lsr-WHBOtttrB5TchPmpVpQA8hBqGFo6Lt_0Pu8lKlN94MSgxw0-01tXEIbp5Dn4vy-1F5q3nMzSM4bRY9QG5ywuJQnDLEd_8WfH-HbGnEb_dEAHAK-5FoLBrsrcevKowVm96LtQbRtou1etNUt8_bpgcvdFsdfiZ9mG8APQG1X0wbLHz_w39bv8FSvTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1691395970</pqid></control><display><type>article</type><title>Health-related quality of life following pediatric critical illness</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Aspesberro, François ; Mangione-Smith, Rita ; Zimmerman, Jerry J.</creator><creatorcontrib>Aspesberro, François ; Mangione-Smith, Rita ; Zimmerman, Jerry J.</creatorcontrib><description>Purpose
The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implemented in pediatric critical care studies to date.
Methods
This was a focused review of the literature from 1980 to 2015 based on a search of EMBASE/PubMed, MEDLINE and PsycInfo assessing trends and determinants of HRQL outcomes in children surviving critical illness. We also evaluated the psychometric properties of the HRQL instruments used in the studies identified by examining each measure’s reported reliability, validity and sensitivity to clinical change.
Results
The literature search identified 253 pediatric articles for potential inclusion in the review, among which data from 78 studies were ultimately selected for inclusion. Of the 22 measures utilized in the studies reviewed, only four demonstrated excellent psychometric properties for use in pediatric critical care trials. Trends in HRQL identified in the studies reviewed suggest significant ongoing morbidity for children surviving critical illness. Key determinants of poor HRQL outcomes include reason for PICU admission (sepsis, meningoencephalitis, trauma), antecedents (chronic comorbid conditions), treatments received (prolonged cardiopulmonary resuscitation, long-stay patients, invasive technology), psychological outcomes (post-traumatic stress disorder, parent anxiety/depression) and social and environmental characteristics (low socioeconomic status, parental education and functioning).
Conclusions
Validated pediatric HRQL instruments are now available. Significant impact on HRQL has been demonstrated in acute and acute on chronic critical illness. Future pediatric critical care interventional trials should include both mortality as well as long-term HRQL measurements to truly ascertain the full impact of critical illness in children.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-015-3780-7</identifier><identifier>PMID: 25851391</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Anesthesiology ; Child ; Child, Preschool ; Children ; Critical care ; Critical Care Medicine ; Critical Illness ; Diseases ; Emergency Medicine ; Health aspects ; Health Status ; Humans ; Illnesses ; Infant ; Infant, Newborn ; Intensive ; Intensive care ; Intensive Care Units, Pediatric ; Literature reviews ; Medical Subject Headings-MeSH ; Medicine ; Medicine & Public Health ; Morbidity ; Mortality ; Outcome Assessment (Health Care) ; Pain Medicine ; Pediatric intensive care ; Pediatrics ; Pneumology/Respiratory System ; Post-traumatic stress disorder ; Psychometrics - methods ; Quality of Life ; Quantitative psychology ; Reproducibility of Results ; Review ; Survivors ; Trends</subject><ispartof>Intensive care medicine, 2015-07, Vol.41 (7), p.1235-1246</ispartof><rights>Springer-Verlag Berlin Heidelberg and ESICM 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-7fd0820d2af553a410c684537832a850dd1ee5e6cfe2860f53189ae1b8171f683</citedby><cites>FETCH-LOGICAL-c613t-7fd0820d2af553a410c684537832a850dd1ee5e6cfe2860f53189ae1b8171f683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-015-3780-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-015-3780-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25851391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aspesberro, François</creatorcontrib><creatorcontrib>Mangione-Smith, Rita</creatorcontrib><creatorcontrib>Zimmerman, Jerry J.</creatorcontrib><title>Health-related quality of life following pediatric critical illness</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Purpose
The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implemented in pediatric critical care studies to date.
Methods
This was a focused review of the literature from 1980 to 2015 based on a search of EMBASE/PubMed, MEDLINE and PsycInfo assessing trends and determinants of HRQL outcomes in children surviving critical illness. We also evaluated the psychometric properties of the HRQL instruments used in the studies identified by examining each measure’s reported reliability, validity and sensitivity to clinical change.
Results
The literature search identified 253 pediatric articles for potential inclusion in the review, among which data from 78 studies were ultimately selected for inclusion. Of the 22 measures utilized in the studies reviewed, only four demonstrated excellent psychometric properties for use in pediatric critical care trials. Trends in HRQL identified in the studies reviewed suggest significant ongoing morbidity for children surviving critical illness. Key determinants of poor HRQL outcomes include reason for PICU admission (sepsis, meningoencephalitis, trauma), antecedents (chronic comorbid conditions), treatments received (prolonged cardiopulmonary resuscitation, long-stay patients, invasive technology), psychological outcomes (post-traumatic stress disorder, parent anxiety/depression) and social and environmental characteristics (low socioeconomic status, parental education and functioning).
Conclusions
Validated pediatric HRQL instruments are now available. Significant impact on HRQL has been demonstrated in acute and acute on chronic critical illness. Future pediatric critical care interventional trials should include both mortality as well as long-term HRQL measurements to truly ascertain the full impact of critical illness in children.</description><subject>Adolescent</subject><subject>Anesthesiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Critical care</subject><subject>Critical Care Medicine</subject><subject>Critical Illness</subject><subject>Diseases</subject><subject>Emergency Medicine</subject><subject>Health aspects</subject><subject>Health Status</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Intensive Care Units, Pediatric</subject><subject>Literature reviews</subject><subject>Medical Subject Headings-MeSH</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pain Medicine</subject><subject>Pediatric intensive care</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Post-traumatic stress disorder</subject><subject>Psychometrics - methods</subject><subject>Quality of Life</subject><subject>Quantitative psychology</subject><subject>Reproducibility of Results</subject><subject>Review</subject><subject>Survivors</subject><subject>Trends</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1vVCEUhomxsWP1B7gxN3HjhpYDl4-7bCZqTZp0U9eEcg8jDXOZwr0x_fcyTv3MGBYk8LxvDjyEvAF2Dozpi8oYiJ4ykFRow6h-RlbQC06BC_OcrJjoOe1Vz0_Jy1rvG62VhBfklEsjQQywIusrdGn-SgsmN-PYPSwuxfmxy6FLMWAXckr5W5w23Q7H6OYSfedLnKN3qYspTVjrK3ISXKr4-mk_I18-frhdX9Hrm0-f15fX1CsQM9VhZIazkbsgpXA9MK9ML9vkgjsj2TgCokTlA3KjWJACzOAQ7gxoCMqIM_L-0Lsr-WHBOtttrB5TchPmpVpQA8hBqGFo6Lt_0Pu8lKlN94MSgxw0-01tXEIbp5Dn4vy-1F5q3nMzSM4bRY9QG5ywuJQnDLEd_8WfH-HbGnEb_dEAHAK-5FoLBrsrcevKowVm96LtQbRtou1etNUt8_bpgcvdFsdfiZ9mG8APQG1X0wbLHz_w39bv8FSvTg</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Aspesberro, François</creator><creator>Mangione-Smith, Rita</creator><creator>Zimmerman, Jerry J.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Health-related quality of life following pediatric critical illness</title><author>Aspesberro, François ; Mangione-Smith, Rita ; Zimmerman, Jerry J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c613t-7fd0820d2af553a410c684537832a850dd1ee5e6cfe2860f53189ae1b8171f683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Anesthesiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Critical care</topic><topic>Critical Care Medicine</topic><topic>Critical Illness</topic><topic>Diseases</topic><topic>Emergency Medicine</topic><topic>Health aspects</topic><topic>Health Status</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Intensive Care Units, Pediatric</topic><topic>Literature reviews</topic><topic>Medical Subject Headings-MeSH</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pain Medicine</topic><topic>Pediatric intensive care</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Post-traumatic stress disorder</topic><topic>Psychometrics - methods</topic><topic>Quality of Life</topic><topic>Quantitative psychology</topic><topic>Reproducibility of Results</topic><topic>Review</topic><topic>Survivors</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aspesberro, François</creatorcontrib><creatorcontrib>Mangione-Smith, Rita</creatorcontrib><creatorcontrib>Zimmerman, Jerry J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aspesberro, François</au><au>Mangione-Smith, Rita</au><au>Zimmerman, Jerry J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Health-related quality of life following pediatric critical illness</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>41</volume><issue>7</issue><spage>1235</spage><epage>1246</epage><pages>1235-1246</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><abstract>Purpose
The aims of this focused review of the literature on children surviving critical illness were to (1) determine whether health-related quality of life (HRQL) represents a clinically meaningful outcome measure for children surviving critical illness and (2) evaluate the HRQL measures implemented in pediatric critical care studies to date.
Methods
This was a focused review of the literature from 1980 to 2015 based on a search of EMBASE/PubMed, MEDLINE and PsycInfo assessing trends and determinants of HRQL outcomes in children surviving critical illness. We also evaluated the psychometric properties of the HRQL instruments used in the studies identified by examining each measure’s reported reliability, validity and sensitivity to clinical change.
Results
The literature search identified 253 pediatric articles for potential inclusion in the review, among which data from 78 studies were ultimately selected for inclusion. Of the 22 measures utilized in the studies reviewed, only four demonstrated excellent psychometric properties for use in pediatric critical care trials. Trends in HRQL identified in the studies reviewed suggest significant ongoing morbidity for children surviving critical illness. Key determinants of poor HRQL outcomes include reason for PICU admission (sepsis, meningoencephalitis, trauma), antecedents (chronic comorbid conditions), treatments received (prolonged cardiopulmonary resuscitation, long-stay patients, invasive technology), psychological outcomes (post-traumatic stress disorder, parent anxiety/depression) and social and environmental characteristics (low socioeconomic status, parental education and functioning).
Conclusions
Validated pediatric HRQL instruments are now available. Significant impact on HRQL has been demonstrated in acute and acute on chronic critical illness. Future pediatric critical care interventional trials should include both mortality as well as long-term HRQL measurements to truly ascertain the full impact of critical illness in children.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25851391</pmid><doi>10.1007/s00134-015-3780-7</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 2015-07, Vol.41 (7), p.1235-1246 |
| issn | 0342-4642 1432-1238 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Adolescent Anesthesiology Child Child, Preschool Children Critical care Critical Care Medicine Critical Illness Diseases Emergency Medicine Health aspects Health Status Humans Illnesses Infant Infant, Newborn Intensive Intensive care Intensive Care Units, Pediatric Literature reviews Medical Subject Headings-MeSH Medicine Medicine & Public Health Morbidity Mortality Outcome Assessment (Health Care) Pain Medicine Pediatric intensive care Pediatrics Pneumology/Respiratory System Post-traumatic stress disorder Psychometrics - methods Quality of Life Quantitative psychology Reproducibility of Results Review Survivors Trends |
| title | Health-related quality of life following pediatric critical illness |
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