The effects of vitamin B6 on lens antioxidant system in valproic acid-administered rats

Valproic acid (VPA, 2-propyl pentanoic acid) is a broad-spectrum antiepileptic drug (AED) and is commonly used in the treatment of bipolar disorders and epilepsy. AEDs are known to result in vascular disturbances. Vitamin B6 (Vit B6) is water soluble vitamin essential for normal growth, development,...

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Veröffentlicht in:	Human & experimental toxicology 2014-06, Vol.33 (6), p.623-628
1. Verfasser:	Tunali, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - toxicity Antioxidants Antioxidants - pharmacology Biological and medical sciences Biomarkers - metabolism Cytoprotection Enzymes - metabolism Epilepsy Glutathione - metabolism Lens, Crystalline - drug effects Lens, Crystalline - enzymology Lipid Peroxidation - drug effects Male Medical sciences Oxidative stress Oxidative Stress - drug effects Pharmacology Rats, Sprague-Dawley Time Factors Toxicity Toxicology Valproic Acid - toxicity Vitamin B Vitamin B 6 - pharmacology
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