Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP

We have shown constitutive expression of the master regulator of osteoblastogenesis, runt‐related transcription factor‐2 (Runx2), by microglia cells outside bone. Here, we attempted to evaluate the pathological significance of Runx2 in microglial BV‐2 cells exposed to ATP at a high concentration. Ma...

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Veröffentlicht in:	Journal of cellular physiology 2015-10, Vol.230 (10), p.2510-2521
Hauptverfasser:	Nakazato, Ryota, Takarada, Takeshi, Ikeno, Shinsuke, Nakamura, Saki, Kutsukake, Takaya, Hinoi, Eiichi, Yoneda, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Line Cells, Cultured Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Matrix Metalloproteinase 13 - metabolism Mice Microglia - metabolism Osteoblasts Promoter Regions, Genetic - genetics Signal Transduction - genetics Transcriptional Activation - physiology Up-Regulation
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